18 hasil untuk "Lin Pan"

Chronic kidney disease associated with decreased bone mineral density, uric acid and metabolic syndrome

Bo-Lin Pan; Song-Seng Loke

PLOS ONE, Vol. 13 No. 1 · 2018 · Inggris · PLOS Scopus

Objective: The relationship between decreased bone mineral density (BMD) and chronic kidney disease (CKD) is controversial. The associations among metabolic syndrome (MetS), serum uric acid and CKD are also unclear. We aimed to investigate the relationship between decreased BMD, MetS, serum uric…

Line strain representation and shear strain representation of 3D strain states

Shunqun Li; Xuelei Cheng; Jianbao Fu dkk.

PLOS ONE, Vol. 16 No. 11 · 2021 · Inggris · PLOS Scopus

The strain state in 3D space is usually expressed by the conventional method of combining three linear and shear strains. Due to the obvious differences between the first two strains, it is necessary to uncover their properties when describing deformation, studying yield and failure, and developing…

Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia

Mitchell C. Krawczyk; Lin Pan; Alice J. Zhang dkk.

PLOS ONE, Vol. 18 No. 2 · 2023 · Inggris · PLOS Scopus

Though the brain was long characterized as an immune-privileged organ, findings in recent years have shown extensive communications between the brain and peripheral immune cells. We now know that alterations in the peripheral immune system can affect the behavioral outputs of the central nervous…

α-Tomatine-Mediated Anti-Cancer Activity In Vitro and In Vivo through Cell Cycle- and Caspase-Independent Pathways

Min-Wu Chao; Chun-Han Chen; Ya-Ling Chang dkk.

Public Library of Science · 2012 · Inggris · PLOS Scopus

α-Tomatine, a tomato glycoalkaloid, has been reported to possess antibiotic properties against human pathogens. However, the mechanism of its action against leukemia remains unclear. In this study, the therapeutic potential of α-tomatine against leukemic cells was evaluated in vitro and in vivo…

Factors Associated with Interstitial Lung Disease in Patients with Polymyositis and Dermatomyositis: A Systematic Review and Meta-Analysis

Li Zhang; Guoqin Wu; Di Gao dkk.

PLOS ONE, Vol. 11 No. 5 · 2016 · Inggris · PLOS Scopus

Objectives: Interstitial lung disease (ILD) is an extramuscular manifestation that results in increased morbidity and mortality from polymyositis (PM) and dermatomyositis (DM). The aim of this study was to systematically evaluate risk factors associated with the development of ILD in PM/DM…

Chlorophyll, carotenoid and vitamin C metabolism regulation in Actinidia chinensis 'Hongyang' outer pericarp during fruit development

Ji-Yu Zhang; De-Lin Pan; Zhan-Hui Jia dkk.

PLOS ONE, Vol. 13 No. 3 · 2018 · Inggris · PLOS Scopus

Ascorbic acid (AsA), chlorophyll and carotenoid contents and their associated gene expression patterns were analysed in Actinidia chinensis ‘Hongyang’ outer pericarp. The results showed chlorophyll degradation during fruit development and softening, exposed the yellow carotenoid pigments. LHCB1 and…

MT-4 Suppresses Resistant Ovarian Cancer Growth through Targeting Tubulin and HSP27

Hui Chen Pai; Sunil Kumar; Chien-Chang Shen dkk.

PLOS ONE, Vol. 10 No. 4 · 2015 · Inggris · PLOS Scopus

Objective: In this study, the anticancer mechanisms of MT-4 were examined in A2780 and multidrug-resistant NCI-ADR/res human ovarian cancer cell lines. Methods: To evaluate the activity of MT-4, we performed in vitro cell viability and cell cycle assays and in vivo xenograft assays. Immunoblotting…

Could prokinetic agents protect long-term nasogastric tube-dependent patients from being hospitalized for pneumonia? A nationwide population-based case-crossover study

Kun-Siang Huang; Bo-Lin Pan; Wei-An Lai dkk.

PLOS ONE, Vol. 16 No. 4 · 2021 · Inggris · PLOS Scopus

Background: Some studies have indicated that the use of prokinetic agents may reduce pneumonia risk in some populations. Nasogastric tube insertion is known to increase the risk of pneumonia because it disrupts lower esophageal sphincter function. The aim of this study was to evaluate whether…

Dehydrocostuslactone Suppresses Angiogenesis In Vitro and In Vivo through Inhibition of Akt/GSK-3β and mTOR Signaling Pathways

Chih-Ya Wang; An-Chi Tsai; Chieh-Yu Peng dkk.

PLoS ONE, Vol. 7 No. 2 · 2012 · Inggris · PLOS Scopus

The traditional Chinese medicine component dehydrocostuslactone (DHC) isolated from Saussurea costus (Falc.) Lipschitz, has been shown to have anti-cancer activity. Angiogenesis is an essential process in the growth and progression of cancer. In this study, we demonstrated, for the first time, the…

NPRL-Z-1, as a New Topoisomerase II Poison, Induces Cell Apoptosis and ROS Generation in Human Renal Carcinoma Cells

Szu-Ying Wu; Shiow-Lin Pan; Zhi-Yan Xiao dkk.

PLoS ONE, Vol. 9 No. 11 · 2014 · Inggris · PLOS Scopus

NPRL-Z-1 is a 4β-[(4″-benzamido)-amino]-4′-O-demethyl-epipodophyllotoxin derivative. Previous reports have shown that NPRL-Z-1 possesses anticancer activity. Here NPRL-Z-1 displayed cytotoxic effects against four human cancer cell lines (HCT 116, A549, ACHN, and A498) and exhibited potent activity…

Analysis of Death Receptor 5 and Caspase-8 Expression in Primary and Metastatic Head and Neck Squamous Cell Carcinoma and Their Prognostic Impact

Heath A. Elrod; Songqing Fan; Susan Muller dkk.

PLoS ONE, Vol. 5 No. 8 · 2010 · Inggris · PLOS Scopus

Death receptor 5 (DR5) and caspase-8 are major components in the extrinsic apoptotic pathway. The alterations of the expression of these proteins during the metastasis of head and neck squamous cell carcinoma (HNSCC) and their prognostic impact have not been reported. The present study analyzes the…

Physalin F Induces Cell Apoptosis in Human Renal Carcinoma Cells by Targeting NF-kappaB and Generating Reactive Oxygen Species

Szu-Ying Wu; Yann-Lii Leu; Ya-Ling Chang dkk.

PLoS ONE, Vol. 7 No. 7 · 2012 · Inggris · PLOS Scopus

Background: The aim of this study was to determine the molecular mechanisms of physalin F, an effective purified extract of Physalis angulata L. (Solanacae), in renal carcinoma A498 cells. Methodology/Principal Findings: Physalin F was observed to significantly induce cytotoxicity of three human…

Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo

Han-Lin Huang; Hsueh-Yun Lee; An-Chi Tsai dkk.

Public Library of Science · 2012 · Inggris · PLOS Scopus

Recently, histone deacetylase (HDAC) inhibitors have emerged as a promising class of drugs for treatment of cancers, especially subcutaneous T-cell lymphoma. In this study, we demonstrated that MPT0E028, a novel N-hydroxyacrylamide-derived HDAC inhibitor, inhibited human colorectal cancer HCT116…

Aciculatin Induces p53-Dependent Apoptosis via MDM2 Depletion in Human Cancer Cells In Vitro and In Vivo

Chin-Yu Lai; An-Chi Tsai; Mei-Chuan Chen dkk.

Public Library of Science · 2012 · Inggris · PLOS Scopus

Aciculatin, a natural compound extracted from the medicinal herb Chrysopogon aciculatus, shows potent anti-cancer potency. This study is the first to prove that aciculatin induces cell death in human cancer cells and HCT116 mouse xenografts due to G1 arrest and subsequent apoptosis. The primary…

Correction: Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo

Han-Li Huang; Hsueh-Yun Lee; An-Chi Tsai dkk.

PLoS ONE, Vol. 7 No. 9 · 2012 · Inggris · PLOS Scopus

Transthoracic Resection versus Non-Transthoracic Resection for Gastroesophageal Junction Cancer: A Meta-Analysis

Kun Yang; Hai-Ning Chen; Xin-Zu Chen dkk.

PLoS ONE, Vol. 7 No. 6 · 2012 · Inggris · PLOS Scopus

Background: The aim of this meta-analysis is to evaluate the impact of transthoracic resection on long-term survival of patients with GEJ cancer and to compare the postoperative morbidity and mortality of patients undergoing transthoracic resection with those of patients who were not undergoing…

A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations

Pei-Ying Kao; Ming-Hui Chen; Wei-An Chang dkk.

PLOS ONE, Vol. 18 No. 2 · 2023 · Inggris · PLOS Scopus

Here in this study we adopted genome-wide association studies (GWAS) to investigate the genetic components of the personality constructs in the Chinese Personality Assessment Inventory 2 (CPAI-2) in Taiwanese Hakka populations, who are likely the descendants of a recent admixture between a group of…

A Gain-of-Function Mutation in Tnni2 Impeded Bone Development through Increasing Hif3a Expression in DA2B Mice

Xiaoquan Zhu; Fengchao Wang; Yanyang Zhao dkk.

PLoS Genetics, Vol. 10 No. 10 · 2014 · Inggris · PLOS Scopus

Distal arthrogryposis type 2B (DA2B) is an important genetic disorder in humans. However, the mechanisms governing this disease are not clearly understood. In this study, we generated knock-in mice carrying a DA2B mutation (K175del) in troponin I type 2 (skeletal, fast) (TNNI2), which encodes a…