666 hasil untuk "Lin Wan"
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Artikel Jurnal Teks lengkap
Association Testing of Clustered Rare Causal Variants in Case-Control Studies
Biological evidence suggests that multiple causal variants in a gene may cluster physically. Variants within the same protein functional domain or gene regulatory element would locate in close proximity on the DNA sequence. However, spatial information of variants is usually not used in current…
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Beyond Rare-Variant Association Testing: Pinpointing Rare Causal Variants in Case-Control Sequencing Study
Rare-variant association testing usually requires some method of aggregation. The next important step is to pinpoint individual rare causal variants among a large number of variants within a genetic region. Recently Ionita-Laza et al. propose a backward elimination (BE) procedure that can identify…
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Adaptive Combination of P-Values for Family-Based Association Testing with Sequence Data
Family-based study design will play a key role in identifying rare causal variants, because rare causal variants can be enriched in families with multiple affected subjects. Furthermore, different from population-based studies, family studies are robust to bias induced by population substructure…
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The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants
Regular physical exercise is recommended to reduce the risk of obesity. However, it remains unclear which activities are more effective in preventing obesity. In this study, five obesity indices and lifestyle factors of 33,731 Taiwan Biobank adults were measured/collected twice with a mean time…
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Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants
BACKGROUND: Obesity adversely influences the central nervous system and cognitive functions. However, the relationship between various obesity indicators and cognitive performance remains controversial. It is unclear which obesity indicator is more relevant to cognitive impairment. METHODS: The…
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Searching for gene-gene interactions through variance quantitative trait loci of 29 continuous Taiwan Biobank phenotypes
Introduction: After the era of genome-wide association studies (GWAS), thousands of genetic variants have been identified to exhibit main effects on human phenotypes. The next critical issue would be to explore the interplay between genes, the so-called “gene-gene interactions” (GxG) or epistasis…
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Detecting gene–environment interactions from multiple continuous traits
MOTIVATION: Genetic variants present differential effects on humans according to various environmental exposures, the so-called “gene–environment interactions” (GxE). Many diseases can be diagnosed with multiple traits, such as obesity, diabetes, and dyslipidemia. I developed a multivariate scale…
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A large-scale observational study linking various kinds of physical exercise to lipoprotein-lipid profile
BACKGROUND: Being a major cardiovascular risk factor, dyslipidemia is a critical problem in public health. Recommendations in performing regular physical exercise are important to prevent dyslipidemia. METHODS: Based on a discovery cohort with 27,735 subjects and a replication cohort with 67,512…
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Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE. These epigenetic clocks were mainly developed by individuals of European or…
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Mining for gene-environment and gene-gene interactions: parametric and non-parametric tests for detecting variance quantitative trait loci
INTRODUCTION: Detection of variance quantitative trait loci (vQTL) can facilitate the discovery of gene-environment (GxE) and gene-gene interactions (GxG). Identifying vQTLs before direct GxE and GxG analyses can considerably reduce the number of tests and the multiple-testing penalty. METHODS…
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Epigenome-wide mediation analysis identified Cytosine-phosphate-Guanine sites linking environmental factors with diabetes indicators
AIMS: Environmental factors can alter DNA methylation (DNAm) levels, influence gene expression, and then change fasting glucose (FG) or hemoglobin A1c (HbA1c). METHODS: Through analyzing DNAm data of 2366 Taiwan Biobank individuals aged between 30 and 70 years, I evaluated the role of DNAm in…
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L-Arabinose inhibits gastric cancer progression by inducing G2/M phase arrest via LC3/Atg5-mediated autophagy downregulating ribosomal protein RPL19
Abstract Objective To clarify the inhibitory effect of monomeric L-arabinose on gastric cancer and elucidate its molecular mechanism, this study aims to investigate whether L-arabinose regulates the cell cycle via the microtubule-associated protein 1 light chain 3/autophagy-related gene 5…
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NeuralEE: A GPU-Accelerated Elastic Embedding Dimensionality Reduction Method for Visualizing Large-Scale scRNA-Seq Data
The dramatic increase in amount and size of single-cell RNA sequencing data calls for more efficient and scalable dimensional reduction and visualization tools. Here, we design a GPU-accelerated method, NeuralEE, which aggregates the advantages of elastic embedding and neural network. We show that…
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Reducing Bias of Allele Frequency Estimates by Modeling SNP Genotype Data with Informative Missingness
The presence of missing single-nucleotide polymorphism (SNP) genotypes is common in genetic studies. For studies with low-density SNPs, the most commonly used approach to dealing with genotype missingness is to simply remove the observations with missing genotypes from the analyses. This naïve…
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A cytokine-mediated link between innate immunity, inflammation, and cancer
It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity…
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Poly(Ethylene Glycol) as a Scaffold for High-Affinity Open-Channel Blockers of the Mouse Nicotinic Acetylcholine Receptor
High-affinity blockers for an ion channel often have complex molecular structures that are synthetically challenging and/or laborious. Here we show that high-affinity blockers for the mouse nicotinic acetylcholine receptor (AChR) can be prepared from a structurally simple material, poly(ethylene…
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Transitions in density, pressure, and effective temperature drive collective cell migration into confining environments
Epithelial cell collectives migrate through tissue interfaces and crevices to orchestrate processes of development, tumor invasion, and wound healing. Naturally, traversal of cell collective through confining environments involves crowding due to the narrowing space, which seems tenuous given the…
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Decoding SIGLEC12 in Bladder Cancer: In Silico Profiling of Expression, Tumor–Immune Interactions, and Prognostic Impact
Background and Objectives: Siglec-XII, encoded by SIGLEC12, is a unique sialic acid-binding immunoglobulin-like lectin. It lacks a highly conserved R122 residue for sialic acid recognition in humans. Although it is upregulated in bladder cancer (BCa), its role in tumorigenesis remains largely…
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An Effective NoSQL-Based Vector Map Tile Management Approach
Within a digital map service environment, the rapid growth of Spatial Big-Data is driving new requirements for effective mechanisms for massive online vector map tile processing. The emergence of Not Only SQL (NoSQL) databases has resulted in a new data storage and management model for scalable…
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Dynamic inference of cell developmental complex energy landscape from time series single-cell transcriptomic data.
Time series single-cell RNA sequencing (scRNA-seq) data are emerging. However, dynamic inference of an evolving cell population from time series scRNA-seq data is challenging owing to the stochasticity and nonlinearity of the underlying biological processes. This calls for the development of…