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Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway

Su-Ran Li; Lin‐Lin Bu; Lulu Cai

Signal Transduction and Targeted Therapy · 2022 · Inggris · OpenAlex Scopus

In a recent study published in Science , Tsvetkov et al 1 . shed a light on a new form of cell death, copper-dependent cell death (termed cuproptosis). They defined “cuproptosis” as a nonapoptotic cell death pathway. They have demonstrated that copper directly binds to lipoylated components of the…