61 hasil untuk "MENG Lingjun"
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Artikel Jurnal Teks lengkap
Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation
The mechanism of nuclear size determination and alteration during normal lineage development and cancer pathologies which is not fully understood. As recently reported, chromatin modification can change nuclear morphology. Therefore, we screened a range of pharmacological chemical compounds that…
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Artikel Jurnal Teks lengkap
KCF_MTSA Algorithm Based on Multiple Features and Scale Estimation
The Kernelized Correlation Filter based on Multiple-Template Scale Adaptation(KCF_MTSA)tracking algorithm encounters a reduction in the tracking range precision and success rate when the target moves blurred,rotates and scales change rapidly.To address the problem,this paper proposes an improved…
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Artikel Jurnal
Convolutional neural network face detection algorithm
Traditional face detection algorithms often cannot extract useful detection features from the original image, and convolutional neural networks can easily extract high-dimensional feature information, which is widely used in image processing. In view of the above shortcomings, a simple and…
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Significant correlation between glucose metabolism status and acute radiation enteritis resulting from concurrent chemoradiotherapy in rectal cancer
Objective: To explore the relationship between glucose metabolism and acute radiation enteritis from chemoradiotherapy for rectal cancer. Methods: In this retrospective study, the clinical data of 75 rectal cancer patients who received concurrent chemoradiotherapy in Binzhou Second People’s…
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Artikel Jurnal Teks lengkap
Nucleostemin: A Latecomer with New Tricks
Nucleostemin was first identified in neural stem cells and has become a focus of research in cell cycle control, tumorigenesis and cellular senescence. As the biology of nucleostemin begins to be unveiled in multiple species, an ensuing task is to resolve the apparent differences between the…
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Artikel Jurnal Teks lengkap
Effect of dendritic cell immunotherapy on distribution of dendritic cell subsets in non-small cell lung cancer
The effect of dendritic cell (DC) immunotherapy on non-small cell lung cancer (NSCLC) and its influence on the distribution of DC subsets were studied. Peripheral blood was drawn from 55 patients, and DCs were cultured in vitro and injected into the patients three times. The changes in DC subsets…
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Artikel Jurnal Teks lengkap
RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality
Systematic inflammation contributes to the development of many diseases, including cardiovascular disease, which is the leading cause of mortality worldwide. How such inflammation is initiated and maintained throughout the course of disease remains unclear. In the current study, we report the…
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Artikel Jurnal Teks lengkap
Transient receptor potential channels in multiple myeloma
Multiple myeloma is the second most commonly diagnosed hematologic malignancy. As an incurable disease, the molecular mechanisms underlying its many aspects remain unclear. Intracellular calcium ion is an essential signaling molecule that modulates malignant cell behavior, and abnormal regulation…
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Artikel Jurnal Teks lengkap
Advancements in the diagnosis and management of capecitabine-induced hand-foot syndrome
PURPOSE: This narrative review aims to synthesize existing evidence on hand-foot syndrome (HFS) associated with capecitabine therapy. By examining HFS pathogenesis, clinical manifestations, severity classifications, influencing factors, and management strategies, the study seeks to provide…
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Artikel Jurnal Teks lengkap
Social Bots Detection Based on Multi-relationship Graph Attention Network
At present,social bots have gained extensive utilization across social platforms and the existence of social bots makes the public opinion environment on the network artificially manipulated.This not only compromises the integrity of a healthy and harmonious online atmosphere but also significantly…
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Artikel Jurnal Teks lengkap
Effect of freezing treatment of raw material on the quality of 'Italian Riesling' wine
Using 'Italian Riesling' grapes as experimental materials, the effects of freezing raw materials at -24 ℃ for 24 h on the basic physicochemical properties, phenolic substances, aroma components and sensory quality of dry white wine were determined by ultra-high performance liquid chromatography…
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Artikel Jurnal Teks lengkap
Multiple Controls Regulate Nucleostemin Partitioning Between Nucleolus and Nucleoplasm
Nucleostemin plays an essential role in maintaining the continuous proliferation of stem cells and cancer cells. The movement of nucleostemin between the nucleolus and the nucleoplasm provides a dynamic way to partition the nucleostemin protein between these two compartments. Here, we showed that…
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Nucleoplasmic Mobilization of Nucleostemin Stabilizes MDM2 and Promotes G2/M Progression and Cell Survival
Nucleolar disassembly occurs during mitosis and nucleolar stress, releasing several MDM2-interactive proteins residing in the nucleolus that share the common activity of p53 stabilization. Here, we demonstrated that mobilization of nucleostemin (NS), a cancer and stem cell-enriched nucleolar…
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GNL3L Depletion Destabilizes MDM2 and Induces p53-Dependent G2/M Arrest
Guanine nucleotide binding protein-like 3-like (GNL3L) is a nucleolar protein and the vertebrate paralogue of nucleostemin (NS). We previously reported that nucleoplasmic mobilization of NS stabilizes MDM2 (mouse double minute 2). Here, we investigated the role of GNL3L as a novel MDM2 regulator…
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Artikel Jurnal Teks lengkap
Nucleolar Trafficking of Nucleostemin Family Proteins: Common versus Protein-Specific Mechanisms
The nucleolus has begun to emerge as a subnuclear organelle capable of modulating the activities of nuclear proteins in a dynamic and cell type-dependent manner. It remains unclear whether one can extrapolate a rule that predicts the nucleolar localization of multiple proteins based on protein…
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Artikel Jurnal Teks lengkap
Correlation between TAP detection and common digestive tract precancerous lesions
The aim of the present study was to investigate the clinical significance of abnormal sugar-chain glycoprotein tumor abnormal protein (TAP) in the screening of common digestive tract pre-cancer colon adenocarcinoma lesions. A total of 50 colitis patients, 50 colon polyp patients and 50 colon…
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Artikel Jurnal Teks lengkap
Long non coding RNA OIP5-AS1 promotes metastasis of breast cancer via miR-340-5p/ZEB2 axis
Breast cancer is the most common invasive cancer in women with the highest number of related deaths which is caused by distal metastasis. Recently, integrated analysis of gene expression profile suggested widespread gene dysregulation in various types of cancer. Research in the past decade has…
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Blastic plasmacytoid dendritic cell neoplasm with genetic mutations in multiple epigenetic modifiers: a case report
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematodermic malignancy derived from plasmacytoid dendritic cell precursors. Despite advances in our understanding of tumor cell surface markers, the pathogenesis of BPDCN remains largely unknown. No standard or optimal…
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Artikel Jurnal Teks lengkap
An identification method of the weak link of stiffness for cantilever beam structure
To find the weak link of the structural stiffness is important to improve machine tool stiffness. However, how to overcome the static deformation with difficulty acquisition is a difficult problem in machine tool structure. The article takes the cantilever beam structure as a numerical example, the…
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Artikel Jurnal Teks lengkap
Research on the dynamic hammering method for identifying weak parts in cantilever structures
Identification of the vulnerabilities in the structural stiffness is one of the most crucial issues in improving this property of machine tools. In this paper, the Flexibility Matrix Diagonal element method, based on hammer testing, is proposed as an effective approach to identifying the stiffness…