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NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress

Mengchi Lin; Hongtao Zhang; Shuai Chen dkk.

Cell Death and Disease, Vol. 17 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Despite the high prevalence of metabolic dysfunction-associated steatohepatitis (MASH), the number of effective therapeutic targets is limited due to a vague understanding of its intricate pathogenesis. In this study, we reported that the expression of nuclear factor erythroid-derived…