39 results for "Ming Lin"

HURP Expression-Assisted Risk Scores Identify Prognosis Distinguishable Subgroups in Early Stage Liver Cancer

Ming-Ling Chang; Shi-Ming Lin; Chau-Ting Yeh

PLoS ONE, Vol. 6 No. 10 · 2011 · English · PLOS Scopus

Background: Hepatoma up-regulated protein (HURP) is a component of the chromatin-dependent pathway for spindle assembly. We examined the prognostic predictive value of HURP in human hepatocellular carcinoma (HCC). Methods: HURP expression was evaluated by immunocytochemistry of fine needle…

Dominant-Negative CK2α Induces Potent Effects on Circadian Rhythmicity

Elaine M Smith; Jui-Ming Lin; Rose-Anne Meissner et al.

PLoS Genetics, Vol. 4 No. 1 · 2008 · English · PLOS Scopus

Circadian clocks organize the precise timing of cellular and behavioral events. In Drosophila, circadian clocks consist of negative feedback loops in which the clock component PERIOD (PER) represses its own transcription. PER phosphorylation is a critical step in timing the onset and termination of…

Economic fluctuations and cardiovascular diseases: A multiple-input time series analysis

Chiachi Bonnie Lee; Chen-Mao Liao; Li-Hsin Peng et al.

PLOS ONE, Vol. 14 No. 8 · 2019 · English · PLOS Scopus

Objectives: Little is known about the gender and age differences associated with the effects of economic fluctuations on hospitalization for cardiovascular diseases. This paper investigates the impact of economic fluctuations on hospitalization for ischemic heart disease (IHD), stroke, and…

Dietary Blue Pigments Derived from Genipin, Attenuate Inflammation by Inhibiting LPS-Induced iNOS and COX-2 Expression via the NF-κB Inactivation

Qiang-Song Wang; Yaozu Xiang; Yuan-Lu Cui et al.

PLoS ONE, Vol. 7 No. 3 · 2012 · English · PLOS Scopus

Background and Purpose: The edible blue pigments produced by gardenia fruits have been used as value-added colorants for foods in East Asia for 20 years. However, the biological activity of the blue pigments derived from genipin has not been reported. Methodology/Principal Findings: The…

Identification and Characterization of a Novel Trehalose Synthase Gene Derived from Saline-Alkali Soil Metagenomes

Ling Jiang; Ming Lin; Yang Zhang et al.

PLoS ONE, Vol. 8 No. 10 · 2013 · English · PLOS Scopus

A novel trehalose synthase (TreS) gene was identified from a metagenomic library of saline-alkali soil by a simple activity-based screening system. Sequence analysis revealed that TreS encodes a protein of 552 amino acids, with a deduced molecular weight of 63.3 kDa. After being overexpressed in…

The Dual Role of an ESCRT-0 Component HGS in HBV Transcription and Naked Capsid Secretion

Shu-Fan Chou; Ming-Lin Tsai; Jyun-Yuan Huang et al.

PLOS Pathogens, Vol. 11 No. 10 · 2015 · English · PLOS Scopus

The Endosomal Sorting Complex Required for Transport (ESCRT) is an important cellular machinery for the sorting and trafficking of ubiquitinated cargos. It is also known that ESCRT is required for the egress of a number of viruses. To investigate the relationship between ESCRT and hepatitis B virus…

Negation mitigates rather than inverts the neural representations of adjectives

Arianna Zuanazzi; Pablo Ripollés; Wy Ming Lin et al.

PLOS Biology, Vol. 22 No. 5 · 2024 · English · PLOS Scopus

Combinatoric linguistic operations underpin human language processes, but how meaning is composed and refined in the mind of the reader is not well understood. We address this puzzle by exploiting the ubiquitous function of negation. We track the online effects of negation (“not”) and intensifiers…

Efficiency and performance tests of the sorptive building materials that reduce indoor formaldehyde concentrations

Kun-Chih Huang; Yaw-Shyan Tsay; Fang-Ming Lin et al.

PLOS ONE, Vol. 14 No. 1 · 2019 · English · PLOS Scopus

The adsorption of volatile organic compounds by building materials reduces the pollutant concentrations in indoor air. We collected three interior building materials with adsorption potentials—latex paint, micro-carbonized plywood, and moisture-buffering siding—used the sorptive building materials…

Removal efficiency of central vacuum system and protective masks to suspended particles from dental treatment

Ming-Hui Liu; Chi-Tsung Chen; Li-Chuan Chuang et al.

PLOS ONE, Vol. 14 No. 11 · 2019 · English · PLOS Scopus

Background: High levels of suspended particulate matters (PMs) and bioaerosols are created by dental procedures. The present study aimed to evaluate the size and concentration of PMs produced by drilling and grinding teeth, and to assess the efficiency of central vacuum system and protective masks…

The pathological structure of the perivascular niche in different microvascular patterns of glioblastoma

Jintao Chen; Sifeng Mao; Haifang Li et al.

PLOS ONE, Vol. 12 No. 8 · 2017 · English · PLOS Scopus

The perivascular niche is critical for intercellular communication between resident cell types in glioblastoma (GBM), and it plays a vital role in maintaining the glioma stem cell (GSC) microenvironment. It is shown in abundant research that different microvascular patterns exist in GBM; and it can…

Dynamic expression of cathepsin L in the black soldier fly ( Hermetia illucens ) gut during Escherichia coli challenge

Yun-Ru Chiang; Han-Tso Lin; Chao-Wei Chang et al.

PLOS ONE, Vol. 19 No. 3 · 2024 · English · PLOS Scopus

The black soldier fly (BSF), Hermetia illucens, has the potential to serve as a valuable resource for waste bioconversion due to the ability of the larvae to thrive in a microbial-rich environment. Being an ecological decomposer, the survival of BSF larvae (BSFL) relies on developing an efficient…

Correction: Dynamic expression of cathepsin L in the black soldier fly ( Hermetia illucens ) gut during Escherichia coli challenge

Yun-Ru Chiang; Han-Tso Lin; Chao-Wei Chang et al.

PLOS One, Vol. 20 No. 10 · 2025 · English · PLOS Scopus

An Occult Hepatitis B-Derived Hepatoma Cell Line Carrying Persistent Nuclear Viral DNA and Permissive for Exogenous Hepatitis B Virus Infection

Chih-Lang Lin; Rong-Nan Chien; Shi-Ming Lin et al.

PLoS ONE, Vol. 8 No. 5 · 2013 · English · PLOS Scopus

Occult hepatitis B virus (HBV) infection is defined as persistence of HBV DNA in liver tissues, with or without detectability of HBV DNA in the serum, in individuals with negative serum HBV surface antigen (HBsAg). Despite accumulating evidence suggesting its important clinical roles, the molecular…

Epidemiology and outcomes of hypoglycemia in patients with advanced diabetic kidney disease on dialysis: A national cohort study

Yeh-Wen Chu; Hsuan-Ming Lin; Jhi-Joung Wang et al.

PLOS ONE, Vol. 12 No. 3 · 2017 · English · PLOS Scopus

Background: Patients with advanced diabetic kidney disease (DKD) behave differently to diabetic patients without kidney disease. We aimed to investigate the associations of hypoglycemia and outcomes after initiation of dialysis in patients with advanced DKD on dialysis. Methods: Using National…

Tyrosine Kinase Inhibitors Regulate OPG through Inhibition of PDGFRβ

Susannah O’Sullivan; Mei Lin Tay; Jian-Ming Lin et al.

PLOS ONE, Vol. 11 No. 10 · 2016 · English · PLOS Scopus

Nilotinib and imatinib are tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). In vitro, imatinib and nilotinib inhibit osteoclastogenesis, and in patients they reduce levels of bone resorption. One of the mechanisms…

Relationships between Degree of Polymerization and Antioxidant Activities: A Study on Proanthocyanidins from the Leaves of a Medicinal Mangrove Plant Ceriops tagal

Hai-Chao Zhou; Nora Fung-yee Tam; Yi-Ming Lin et al.

PLoS ONE, Vol. 9 No. 10 · 2014 · English · PLOS Scopus

Tannins from the leaves of a medicinal mangrove plant, Ceriops tagal, were purified and fractionated on Sephadex LH-20 columns. 13C nuclear magnetic resonance (13C-NMR), reversed/normal high performance liquid chromatography electrospray ionization mass spectrometry (HPLC-ESI MS) and…

Metabolomics-guided machine learning reveals diagnostic and mechanistic biomarkers in CHB with MASLD

Chuyang Wang; Yutao Chen; Huanming Xiao et al.

PLOS One, Vol. 21 No. 2 · 2026 · English · PLOS Scopus

Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) often coexists with chronic hepatitis B (CHB), yet early diagnosis remains challenging, particularly in non-obese patients or those with subclinical features. This study aimed to identify metabolic signatures of…

Real-Time Electrochemical Recording of Dopamine Release under Optogenetic Stimulation

Wen-Tai Chiu; Che-Ming Lin; Tien-Chun Tsai et al.

PLoS ONE, Vol. 9 No. 2 · 2014 · English · PLOS Scopus

Dopaminergic PC12 cells can synthesize and release dopamine, providing a good cellular model for investigating dopamine regulation. Optogenetic stimulation of channelrhodopsin-2 provides high spatial and temporal precision for selective stimulation as a powerful neuromodulation tool for…

Arterial Spin Labeling Perfusion Study in the Patients with Subacute Mild Traumatic Brain Injury

Che-Ming Lin; Ying-Chi Tseng; Hui-Ling Hsu et al.

PLOS ONE, Vol. 11 No. 2 · 2016 · English · PLOS Scopus

Background: This study uses a MRI technique, three-dimension pulse continuous arterial spin labeling (3D-PCASL), to measure the patient’s cerebral blood flow (CBF) at the subacute stage of mild traumatic brain injury (MTBI) in order to analyze the relationship between cerebral blood flow and…

The impact of COVID-19 vaccination on long-term risk of new-onset atrial fibrillation/flutter after COVID-19 infection: A retrospective cohort study

Ching-Chung Ko; Jheng-Yan Wu; Kuo-Chuan Hung et al.

PLOS One, Vol. 21 No. 4 · 2026 · English · PLOS Scopus

Purpose: COVID-19 infection has been associated with cardiovascular complications, including new-onset atrial fibrillation/flutter (NOAF). However, the potential protective effect of COVID-19 vaccination against long-term NOAF risk following COVID-19 infection remains unclear. Methods: This…