5 hasil untuk "Misbahuddin"

Identification of homozygous missense variant in SIX5 gene underlying recessive nonsyndromic hearing impairment

Mohib Ullah Kakar; Muhammad Akram; Muhammad Zubair Mehboob dkk.

PLOS ONE, Vol. 17 No. 6 · 2022 · Inggris · PLOS Scopus

Hearing impairment (HI) is a heterogeneous condition that affects many individuals globally with different age groups. HI is a genetically and phenotypically heterogeneous disorder. Over the last several years, many genes/loci causing rare autosomal recessive and dominant forms of hearing…

Unrevealing the multitargeted potency of 3-1-BCMIYPPA against lung cancer structural maintenance and suppression proteins through pharmacokinetics, QM-DFT, and multiscale MD simulation studies

Mohammed Ali Alshehri; Saeed A. Asiri; Nawal Helmi dkk.

PLOS ONE, Vol. 19 No. 6 · 2024 · Inggris · PLOS Scopus

Lung cancer, a relentless and challenging disease, demands unwavering attention in drug design research. Single-target drugs have yielded limited success, unable to effectively address this malignancy’s profound heterogeneity and often developed resistance. Consequently, the clarion call for lung…

Heptapharmacological activity of Quercetin-3-O-phosphate against lung cancer pathways

Maryam Abdulrahman Alahdal; Hadil Alahdal; Najat Binothman dkk.

PLOS One, Vol. 21 No. 7 · 2026 · Inggris · PLOS Scopus

Lung cancer is one of the leading causes of cancer-related deaths globally, with smoking being the primary risk factor, though environmental exposures and genetic mutations also play significant roles. Lung cancer arises when abnormal lung cells grow uncontrollably, leading to over 2 million new…

Correction: Evaluating the pentapharmacological potency of otamixaban against lung cancer CDK2, transferase, oxidoreductase and signalling proteins

Hanadi M. Baeissa; Tahani Bakhsh; Afnan Mohammed Shakoori dkk.

PLOS One, Vol. 21 No. 3 · 2026 · Inggris · PLOS Scopus

Evaluating the pentapharmacological potency of otamixaban against lung cancer CDK2, transferase, oxidoreductase and signalling proteins

Hanadi M. Baeissa; Tahani Bakhsh; Afnan Mohammed Shakoori dkk.

PLOS One, Vol. 20 No. 10 · 2025 · Inggris · PLOS Scopus

Lung cancer remains the leading cause of cancer-related mortality worldwide. With approximately 2.2 million new cases and 1.8 million deaths annually, it contributes to 18% of all cancer fatalities. The high mortality rate, limited accessibility to affordable treatments, and the emergence of drug…