21 results for "Muhammad, Atif"
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clusTransition: An R package for monitoring transition in cluster solutions of temporal datasets
Clustering analysis’ primary purpose is to divide a dataset into a finite number of segments based on the similarities between items. In recent years, a significant amount of study has focused on the spatio-temporal aspects of clustering. However, clusters are no longer regarded as static objects…
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The least sample size essential for detecting changes in clustering solutions of streaming datasets
The clustering analysis approach treats multivariate data tuples as objects and groups them into clusters based on their similarities or dissimilarities within the dataset. However, in modern world, a significant volume of data is continuously generated from diverse sources over time. In these…
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Establishing consensus on the implementation of Anticoagulation Stewardship Program with cardiologists in Pakistan: A Delphi study
Background: The Anticoagulation Stewardship Program (ASP) improves clinical outcomes, promotes patient safety, and supports healthcare systems in delivering high-quality, evidence-based anticoagulation management. This study aimed to develop a consensus among cardiologists about the implementation…
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Rights and Responsibilities of Tuberculosis Patients, and the Global Fund: A Qualitative Study
Background: Implementation of the Charter to protect patients’ rights is an important criterion to achieve patient-centered approach and receive financial support from the Global Fund. Our study aims to explore the knowledge of tuberculosis (TB) patients about their rights and responsibilities at…
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Determinants and efficiency of Pakistan’s chemical products’ exports: An application of stochastic frontier gravity model
The estimation of efficiency of industry-specific exports is very important to find exports’ gap and to frame exports promotion policy for targeted industry. This study attempts to investigate the main determinants of chemical products’ exports of Pakistan with 62 trading partners by applying…
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Fucosyltransferase 2 inhibitors: Identification via docking and STD-NMR studies
Fucosyltransferase 2 (FUT2) catalyzes the biosynthesis of A, B, and H antigens and other important glycans, such as (Sialyl Lewisx) sLex, and (Sialyl Lewisy) sLey. The production of these glycans is increased in various cancers, hence to design and develop specific inhibitors of FUT2 is a…
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Treatment outcomes, antibiotic use and its resistance pattern among neonatal sepsis patients attending Bahawal Victoria Hospital, Pakistan
Background: Sepsis is one of the major causes of neonatal mortality in Pakistan. This study aimed to investigate the treatment outcomes, antibiotic use and its resistance pattern among neonatal sepsis patients attending a tertiary care hospital in Pakistan. We also aimed to identify the factors…
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Drug repurposing against fucosyltransferase-2 via docking, STD-NMR, and molecular dynamic simulation studies
Aberrant fucosylation is the hallmark of malignant cell transformation, leading to many cellular events, such as uncontrolled cell proliferation, angiogenesis, tumor cell invasion, and metastasis. This increased fucosylation is caused due to the over-expression of fucosyltransferases (FUTs) that…
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Identification of induced mutations in hexaploid wheat genome using exome capture assay
Wheat is a staple food crop of many countries. Improving resilience to biotic and abiotic stresses remain key breeding targets. Among these, rust diseases are the most detrimental in terms of depressing wheat production. In the present study, chemical mutagenesis was used to induce mutations in the…
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Statistical analysis of Covid-19 mortality rate via probability distributions
Among other diseases, Covid 19 creates a critical situation around the world. Five layers have been recorded so far, resulting in the loss of millions of lives in different countries. The virus was thought to be contagious, so the government initially severely forced citizens to keep a distance…
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Factors affecting patients’ knowledge about dispensed medicines: A Qualitative study of healthcare professionals and patients in Pakistan
Background: Patients’ knowledge about their prescribed medicines is one of the most important antecedents of successful therapy. Poor knowledge about medicines can lead to serious consequences such as non-adherence and misunderstanding of the significance of adverse events. The objective of this…
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Evolution of basic human values orientations: An application of monitoring changes in cluster solutions
This study enumerates the evolution of basic human values orientations and the dynamic relationship between them, computed from Schwartz’s value survey conducted in European nations. For this purpose, eight datasets related to the human value scale were extracted from the European Social Survey…
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Regulation of Human T-Lymphotropic Virus Type I Latency and Reactivation by HBZ and Rex
Human T lymphotropic virus type I (HTLV-I) infection is largely latent in infected persons. How HTLV-1 establishes latency and reactivates is unclear. Here we show that most HTLV-1-infected HeLa cells become senescent. By contrast, when NF-κB activity is blocked, senescence is averted, and infected…
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HIV-1 Vpr Induces Interferon-Stimulated Genes in Human Monocyte-Derived Macrophages
Macrophages act as reservoirs of human immunodeficiency virus type 1 (HIV-1) and play an important role in its transmission to other cells. HIV-1 Vpr is a multi-functional protein involved in HIV-1 replication and pathogenesis; however, its exact role in HIV-1-infected human macrophages remains…
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Democracy’s limited impact on innovation: Panel data evidence from developing countries
This study investigates the relationship between democracy and innovation across 61 developing countries from 2013 to 2020, utilizing data from Global Innovation Index. Employing the Freedom House Index and Polity2 indicators as proxies for democracy, research employs Ordinary Least Squares (OLS)…
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RETRACTED: Country-level institutional quality and financial system efficiency: An international evidence
The optimum economic outcome of financial system development depends on its level of efficiency. The purpose of this study is to investigate the effect of institutional quality on financial system efficiency. For empirical analysis, we have used a panel dataset of 108 countries from 1996–2020 and…
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Prevalence and Predictors of Iron Deficiency Anemia in Children under Five Years of Age in Pakistan, A Secondary Analysis of National Nutrition Survey Data 2011–2012
Background: Iron deficiency Anemia (IDA) in children is a recognized public health problem that impacts adversely on child morbidity, mortality and impairs cognitive development. In Pakistan information on the true prevalence and predictors of IDA is limited. This study sought to investigate IDA in…
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Exploring in-vitro antioxidant, cytotoxicity, hemolytic, thrombolytic and anticancer potentials of Ochthochloa compressa (Forssk.) Hilu
Background: Globally, medicinal plants are found therapeutically very effective against many illnesses. Still there is huge demand of plant based alternate medicines in market. The therapeutic potential of many plants is still unexplored. One such medicinal plant is Ochthochloa compressa, a member…
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Charantin targets HMGCR-PCSK9 axis and activates PPAR-α signaling to ameliorate hyperlipidemia: Mechanistic insights from bioinformatics and in-vivo studies
Plant-derived compounds have recently gained attention owing to their better safety profile and multi-targeted actions. Charantin, a plant-based natural compound known for its diverse pharmacological properties, was investigated for its anti-hyperlipdemic activity using both in-silico and in-vivo…
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Phylogenomic curation of Ovate Family Proteins (OFPs) in the U’s Triangle of Brassica L. indicates stress-induced growth modulation
The Ovate Family Proteins (OFPs) gene family houses a class of proteins that are involved in regulating plant growth and development. To date, there is no report of the simultaneous functional characterization of this gene family in all members of U’s Triangle of Brassica. Here, we retrieved a…