18 hasil untuk "Muhammad Saeed"
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Development of hamming and hausdorff distance metrics for cubic intuitionistic fuzzy hypersoft set in cement storage quality control: Development and evaluation
Quality control is paramount in product manufacturing as it ensures consistent production to meet customer expectations, regulatory requirements and maintain a company’s reputation and profitability. Distance measures within fuzzy sets serve as powerful tools for quality control, allowing for data…
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Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer
Retinoblastoma like protein-2 (Rbl2) is functionally regulated by phosphorylation and acetylation. Previously, we demonstrated that lysine K1083 (K1079 in human Rbl2) is a potential target for acetylation but its functional role remains elusive. We investigated alterations in human Rbl2 gene…
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Theoretical framework for a decision support system for micro-enterprise supermarket investment risk assessment using novel picture fuzzy hypersoft graph
Risk evaluation has always been of great interest for individuals wanting to invest in various businesses, especially in the marketing and product sale centres. A finely detailed evaluation of the risk factor can lead to better returns in terms of investment in a particular business. Considering…
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In Vitro Phosphorylation and Acetylation of the Murine Pocket Protein Rb2/p130
The retinoblastoma protein (pRb) and the related proteins Rb2/p130 and 107 represent the “pocket protein” family of cell cycle regulators. A key function of these proteins is the cell cycle dependent modulation of E2F-regulated genes. The biological activity of these proteins is controlled by…
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Some novel concepts of interval-valued q-rung orthopair fuzzy graphs and computational framework of fuzzy air conditioning system
The interval-valued q-rung orthopair fuzzy sets being an extension of interval-valued intuitionistic and interval-valued Pythagorean fuzzy sets is more flexible model to address vague information that has only two attributes yes or no. The combination of the concept of graph structures with…
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In vitro 5-LOX inhibitory and antioxidant potential of isoxazole derivatives
5-Lipoxygenase (5-LOX) is a key enzyme involved in the biosynthesis of pro-inflammatory leukotrienes, leading to asthma. Developing potent 5-LOX inhibitors are highly attractive. In this research the previously synthesized isoxazole derivatives has been investigated against 5-LOX inhibitory and…
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Endophytic bacteria of Fagonia indica Burm. f revealed to harbour rich secondary antibacterial metabolites
Endophytic bacteria are the source of novel bioactive compounds, used as therapeutic agent. Molecular docking is a computational technique use frequently, to find novel drugs targets and drugs-receptors interactions. The current study was designed to isolate and identify endophytic bacteria for the…
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Does green investment affect environment pollution: Evidence from asymmetric ARDL approach?
Pollution in the environment is today the biggest issue facing the globe and the main factor in the development of many fatal diseases. The main objective of the study to investigate green investments, economic growth and financial development on environmental pollution in the G-7 countries. This…
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Knowledge management process, knowledge based innovation: Does academic researcher’s productivity mediate during the pandemic of covid-19?
Drucker’s knowledge-worker productivity theory and knowledge-based view of the firm theory are widely employed in many disciplines but there is little application of these theories in knowledge-based innovation among academic researchers. Therefore, this study intends to evaluate the effects of the…
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Promoter Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast Cancer
Background: Aberrant expression of tumor suppressor genes may correspond to the abnormal cell development and tumorigenesis. Rbl2/p130, a member of retinoblastoma family of proteins, has growth suppressive properties. Numerous studies reported de-regulation of Rbl2/p130 in various types of cancer…
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RETRACTED: Magnetic Properties of Polyvinyl Alcohol and Doxorubicine Loaded Iron Oxide Nanoparticles for Anticancer Drug Delivery Applications
The current study emphasizes the synthesis of iron oxide nanoparticles (IONPs) and impact of hydrophilic polymer polyvinyl alcohol (PVA) coating concentration as well as anticancer drug doxorubicin (DOX) loading on saturation magnetization for target drug delivery applications. Iron oxide…
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Genome-wide analysis of codon usage bias in four sequenced cotton species
Codon usage bias (CUB) is an important evolutionary feature in a genome which provides important information for studying organism evolution, gene function and exogenous gene expression. The CUB and its shaping factors in the nuclear genomes of four sequenced cotton species, G. arboreum (A2), G…
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Niche suitability and spatial distribution patterns of anurans in a unique Ecoregion mosaic of Northern Pakistan
The lack of information regarding biodiversity status hampers designing and implementing conservation strategies and achieving future targets. Northern Pakistan consists of a unique ecoregion mosaic which supports a myriad of environmental niches for anuran diversity in comparison to the deserts…
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Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography
Extracellular vesicles (EVs) are a heterogeneous population of biological particles released by cells. They represent an attractive source of potential biomarkers for early detection of diseases such as cancer. However, it is critical that sufficient amounts of EVs can be isolated and purified in a…
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Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus
Skin auto fluorescence (SAF) is used as a proxy for the accumulation of advanced glycation end products (AGEs) and has been proposed to stratify patients into cardiovascular disease (CVD) and diabetes mellitus (DM) risk groups. This study evaluates the effects of seven different ethnicities (Arab…
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Artikel Jurnal Teks lengkap
Catechol-O-Methyltransferase Expression and 2-Methoxyestradiol Affect Microtubule Dynamics and Modify Steroid Receptor Signaling in Leiomyoma Cells
Context: Development of optimal medicinal treatments of uterine leiomyomas represents a significant challenge. 2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action of CYP450s and catechol-O-methyltransferase (COMT). Our previous study demonstrated that 2ME is a…
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Combined application of zinc-lysine chelate and zinc-solubilizing bacteria improves yield and grain biofortification of maize ( Zea mays L.)
Malnutrition a health disorders arising due to over or low use of minerals, vitamins and nutritional substances required for proper functioning of body tissues and organs. Zinc (Zn) is the most important mineral required for the normal metabolism of plants and humans. Zinc-deficiency is one of the…