7 hasil untuk "Nguyen, Dat P."
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Artikel Jurnal Teks lengkap
Scope and Limitations of Reductive Amination Catalyzed by Half-Sandwich Iridium Complexes Under Mild Reaction Conditions
The conversion of aldehydes and ketones to 1° amines could be promoted by half-sandwich iridium complexes using ammonium formate as both the nitrogen and hydride source. To optimize this method for green chemical synthesis, we tested various carbonyl substrates in common polar solvents at…
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Artikel Jurnal Teks lengkap
Tools and Methods for Investigating Synthetic Metal-Catalyzed Reactions in Living Cells
Although abiotic catalysts are capable of promoting numerous new-to-nature reactions, only a small subset has so far been successfully integrated into living systems. Research in intracellular catalysis requires an interdisciplinary approach that takes advantage of both chemical and biological…
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Artikel Jurnal Teks lengkap
Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay
BACKGROUND: Glucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors. A novel immunohistochemistry (IHC) based assay has been previously developed and validated in order to assess…
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Artikel Jurnal Teks lengkap
A copper-mediated reverse aromatic Finkelstein reaction in ionic liquid
We have developed a general method for reverse aromatic Finkelstein reactions. Good reaction yields were obtained when aryl iodides or aryl bromides were treated with copper halide salts as promoters in a 1-butyl-3-methylimidazolium bromide ([BMIM]Br) ionic liquid (IL) solvent at 140 °C for 8 h…
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Artikel Jurnal Teks lengkap
Photoinduced Carboborative Ring Contraction Enables Regio- and Stereoselective Synthesis of Multiply Substituted Five-Membered Carbocycles and Heterocycles
We report herein a photoinduced carboborative ring contraction of monounsaturated six-membered carbocycles and heterocycles. The reaction produces substituted five-membered ring systems stereoselectively and on preparative scales. The products feature multiple stereocenters, including contiguous…
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Artikel Jurnal Teks lengkap
Enhanced Prediction of Absorption and Emission Wavelengths of Organic Compounds through Hybrid Graph Neural Network Architectures
The prediction of absorption and emission spectra is a crucial task in chemistry and materials science, traditionally addressed with computational methods, such as density functional theory (DFT). While DFT can deliver with high accuracy, its substantial computational cost and long run times hinder…
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Artikel Jurnal Teks lengkap
Novel variants of CYP21A2 in Vietnamese patients with congenital adrenal hyperplasia
BACKGROUND: Congenital adrenal hyperplasia (CAH) (OMIM #201910) is a complex disease most often caused by pathogenic variant of the CYP21A2 gene. We have designed an efficient multistep approach to diagnose and classify CAH cases due to CYP21A2 variant and to study the genotype‐phenotype…