19 results for "Nguyen, Dat T."
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Sibling method increases risk assessment estimates for type 1 diabetes
We presented a risk assessment model to distinguish between type 1 diabetes (T1D) affected and unaffected siblings using only three single nucleotide polymorphism (SNP) genotypes. In addition we calculated the heritability from genome-wide identity-by-descent (IBD) sharing between full siblings. We…
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A cross-country analysis on diversification, Sukuk investment, and the performance of Islamic banking systems under the COVID-19 pandemic
This study investigates the relationship between diversification and Islamic banking systems' performance under the impact of the COVID-19 turmoil using a sample of 24 countries from 2013Q4 and 2020Q4. The findings indicate that the performance of Islamic banking systems is positively associated…
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Middle and Distal Common Carotid Artery Stenting: Long-Term Patency Rates and Risk Factors for In-Stent Restenosis
PURPOSE: In the absence of literature data, we aimed to determine the long-term patency rates of middle/distal common carotid artery (CCA) stenting and to investigate predisposing factors in the development of in-stent restenosis (ISR). MATERIALS AND METHODS: Fifty-one patients (30 males, median…
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Synthesis and evaluation of N-arylsulfonylated succinimides as activity-based probes
Activity-based protein profiling (ABPP) technology has served as a powerful platform for studying proteins for more than two decades. However, the further growth of this field depends on the development of new probe structures to expand the proportion of the proteome that can be studied using these…
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Assembly of Functionalized Organic Fragments via Reductive Activation and (Cross)‐Coupling of C(2)H(4), CO, CO(2) and/or H(2) Using a Magnesium‐Dinitrogen Complex
Reactions of 1,2‐dimagnesioethane compound [{K((TCHP)NON)Mg}(2)(μ‐C(2)H(4))] ((TCHP)NON = 4,5‐bis(2,4,6‐tricyclohexylanilido)‐2,7‐diethyl‐9,9‐dimethyl‐xanthene), formed by the two‐electron reduction of ethene with a dimagnesium/dipotassium complex of reduced N(2), viz…
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Complete Genome Sequence of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Siphophage Sushi
Klebsiella pneumoniae is a Gram-negative bacterium in the family Enterobacteriaceae. It is associated with numerous nosocomial infections, including respiratory and urinary tract infections in humans. The following reports the complete genome sequence of K. pneumoniae carbapenemase-producing K…
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Ambient health sensing on passive surfaces using metamaterials
Ambient sensors can continuously and unobtrusively monitor a person’s health and well-being in everyday settings. Among various sensing modalities, wireless radio-frequency sensors offer exceptional sensitivity, immunity to lighting conditions, and privacy advantages. However, existing wireless…
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Steroid Components of Marine-Derived Fungal Strain Penicillium levitum N33.2 and Their Biological Activities
Genus Penicillium comprising the most important and extensively studied fungi has been well-known as a rich source of secondary metabolites. Our study aimed to analyze and investigate biological activities, including in vitro anti-cancer, anti-inflammatory and anti-diabetic properties, of…
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Digitally-defined ultrathin transparent wireless sensor network for room-scale imperceptible ambient intelligence
Wireless and battery-free radio-frequency (RF) sensors can be used to create physical spaces that ambiently sense and respond to human activities. Making such sensors ultra-flexible and transparent is important to preserve the aesthetics of living environments, accommodate daily activities, and…
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Steric Control in Low-Valent Mn Diamide Complexes: Contrasting Magnesium and Manganese in N(2) and Benzene Activation
Reduction of Mn(II) precursors with bulky diamide ligands provided access to a complex with the longest known Mn–Mn bond and to a rare example of N(2) activation at high-spin Mn(I) centers. While some instructive parallels can thus be drawn to observations made for Mg analogues, the accessibility…
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Mfsd7b facilitates choline transport and missense mutations affect choline transport function
MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small molecules. Two isoforms of MFSD7b have been identified and they are reported to be heme exporters that play a crucial role in maintaining the cytosolic and mitochondrial heme levels, respectively. Mutations of…
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Implant-to-implant wireless networking with metamaterial textiles
Implanted bioelectronic devices can form distributed networks capable of sensing health conditions and delivering therapy throughout the body. Current clinically-used approaches for wireless communication, however, do not support direct networking between implants because of signal losses from…
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Precocious infant fecal microbiome promotes enterocyte barrier dysfuction, altered neuroendocrine signaling and associates with increased childhood obesity risk
Early life gut microbiome composition has been correlated with childhood obesity, though microbial functional contributions to disease origins remain unclear. Here, using an infant birth cohort (n = 349) we identify a distinct fecal microbiota composition in 1-month-old infants with the lowest rate…
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Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models
Accumulation of sphingolipids, especially sphingosines, in the lysosomes is a key driver of several lysosomal storage diseases. The transport mechanism for sphingolipids from the lysosome remains unclear. Here, we identified SPNS1, which shares the highest homology to SPNS2, a…
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Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature
AIMS: Circulating levels of sphingosine 1-phosphate (S1P), an HDL-associated ligand for the endothelial cell (EC) protective S1P receptor-1 (S1PR1), are reduced in disease states associated with endothelial dysfunction. Yet, as S1PR1 has high affinity for S1P and can be activated by…
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Survival after out-of-hospital cardiac arrest, Viet Nam: multicentre prospective cohort study
OBJECTIVE: To investigate factors associated with survival after out-of-hospital cardiac arrest in Viet Nam. METHODS: We did a multicentre prospective observational study of people (> 18 years) presenting with out-of-hospital cardiac arrest (not caused by trauma) to three tertiary hospitals in Viet…
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A flexible multiplexed immunosensor for point-of-care in situ wound monitoring
Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited…
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MFSD7c functions as a transporter of choline at the blood–brain barrier
Mutations in the orphan transporter MFSD7c (also known as Flvcr2), are linked to Fowler syndrome. Here, we used Mfsd7c knockout (Mfsd7c(–/–)) mice and cell-based assays to reveal that MFSD7c is a choline transporter at the blood–brain barrier (BBB). We performed comprehensive metabolomics analysis…