4 hasil untuk "Nicholas Rhind"
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Artikel Jurnal Teks lengkap
The Role of Specific Checkpoint-Induced S-Phase Transcripts in Resistance to Replicative Stress
Checkpoint activation during S phase modulates transcription. In response to replication arrest, the fission yeast Cds1 checkpoint kinase maintains the normal S-phase transcriptional program by regulating MBF, the S-phase transcription factor. We show that similar regulation occurs in response to…
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Artikel Jurnal Teks lengkap
The capacity of origins to load MCM establishes replication timing patterns
Loading of the MCM replicative helicase at origins of replication is a highly regulated process that precedes DNA replication in all eukaryotes. The stoichiometry of MCM loaded at origins has been proposed to be a key determinant of when those origins initiate replication during S phase…
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Artikel Jurnal Teks lengkap
pomBseen: An automated pipeline for analysis of fission yeast images
Fission yeast is a model organism widely used for studies of eukaryotic cell biology. As such, it is subject to bright-field and fluorescent microscopy. Manual analysis of such data can be laborious and subjective. Therefore, we have developed pomBseen, an image analysis pipeline for the…
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Artikel Jurnal Teks lengkap
Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA
In response to DNA damage during S phase, cells slow DNA replication. This slowing is orchestrated by the intra-S checkpoint and involves inhibition of origin firing and reduction of replication fork speed. Slowing of replication allows for tolerance of DNA damage and suppresses genomic…