15 hasil untuk "P. Kumar"

Identification of Retinal Transformation Hot Spots in Developing Drosophila Epithelia

Claire L. Salzer; Justin P. Kumar

PLoS ONE, Vol. 5 No. 1 · 2010 · Inggris · PLOS Scopus

Background: The retinal determination (RD) network is an evolutionarily conserved regulatory circuit that governs early events in the development of eyes throughout the animal kingdom. Ectopic expression of many members of this network leads to the transformation of non-retinal epithelia into eye…

Pragmatic Perspective on Conservation Genetics and Demographic History of the Last Surviving Population of Kashmir Red Deer ( Cervus elaphus hanglu ) in India

Mukesh; Ved P. Kumar; Lalit K. Sharma dkk.

PLOS ONE, Vol. 10 No. 2 · 2015 · Inggris · PLOS Scopus

The hangul (Cervus elaphus hanglu) is of great conservation concern because it represents the easternmost and only hope for an Asiatic survivor of the red deer species in the Indian subcontinent. Despite the rigorous conservation efforts of the Department of Wildlife Protection in Jammu & Kashmir…

A Hormone-Responsive C1-Domain-Containing Protein At5g17960 Mediates Stress Response in Arabidopsis thaliana

Ravindran Vijay Bhaskar; Bijayalaxmi Mohanty; Vivek Verma dkk.

PLOS ONE, Vol. 10 No. 1 · 2015 · Inggris · PLOS Scopus

Phytohormones play a critical role in mediating plant stress response. They employ a variety of proteins for coordinating such processes. In Arabidopsis thaliana, some members of a Cys-rich protein family known as C1-clan proteins were involved in stress response, but the actual function of the…

A Novel System for the Launch of Alphavirus RNA Synthesis Reveals a Role for the Imd Pathway in Arthropod Antiviral Response

Vasanthi Avadhanula; Brandon P. Weasner; Gail G. Hardy dkk.

PLoS Pathogens, Vol. 5 No. 9 · 2009 · Inggris · PLOS Scopus

Alphaviruses are RNA viruses transmitted between vertebrate hosts by arthropod vectors, primarily mosquitoes. How arthropods counteract alphaviruses or viruses per se is not very well understood. Drosophila melanogaster is a powerful model system for studying innate immunity against bacterial and…

Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements

Bonnie M. Weasner; Brandon P. Weasner; Sarah D. Neuman dkk.

PLOS Genetics, Vol. 12 No. 12 · 2016 · Inggris · PLOS Scopus

The eyes absent (eya) gene of the fruit fly, Drosophila melanogaster, is a member of an evolutionarily conserved gene regulatory network that controls eye formation in all seeing animals. The loss of eya leads to the complete elimination of the compound eye while forced expression of eya in…

Drosophila Dyrk2 Plays a Role in the Development of the Visual System

Nathan Luebbering; Mark Charlton-Perkins; Justin P. Kumar dkk.

PLoS ONE, Vol. 8 No. 10 · 2013 · Inggris · PLOS Scopus

The DYRKs (dual-specificity tyrosine phosphorylation-regulated kinases) are a conserved family of protein kinases that are associated with a number of neurological disorders, but whose biological targets are poorly understood. Drosophila encodes three Dyrks: minibrain/Dyrk1A, DmDyrk2, and DmDyrk3…

Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks

Sneha Palliyil; Jinjin Zhu; Luke R. Baker dkk.

PLOS Genetics, Vol. 14 No. 1 · 2018 · Inggris · PLOS Scopus

A common occurrence in metazoan development is the rise of multiple tissues/organs from a single uniform precursor field. One example is the anterior forebrain of vertebrates, which produces the eyes, hypothalamus, diencephalon, and telencephalon. Another instance is the Drosophila wing disc, which…

Identification and Characterization of RcMADS1 , an AGL24 Ortholog from the Holoparasitic Plant Rafflesia cantleyi Solms-Laubach (Rafflesiaceae)

Rengasamy Ramamoorthy; Edwin Ek-Kian Phua; Saw-Hoon Lim dkk.

PLoS ONE, Vol. 8 No. 6 · 2013 · Inggris · PLOS Scopus

Rafflesia, a holoparasitic genus that produces the largest flower in the world is characterized by the absence of leaves, stem and other macroscopic organs. To better understand the molecular regulation of flower development in this genus we isolated and characterized a floral MADS-box gene…

Live Imaging Provides New Insights on Dynamic F-Actin Filopodia and Differential Endocytosis during Myoblast Fusion in Drosophila

Shruti Haralalka; Claude Shelton; Heather N. Cartwright dkk.

PLoS ONE, Vol. 9 No. 12 · 2014 · Inggris · PLOS Scopus

The process of myogenesis includes the recognition, adhesion, and fusion of committed myoblasts into multinucleate syncytia. In the larval body wall muscles of Drosophila, this elaborate process is initiated by Founder Cells and Fusion-Competent Myoblasts (FCMs), and cell adhesion molecules…

Predictive Value of Sp1/Sp3/FLIP Signature for Prostate Cancer Recurrence

Roble G. Bedolla; Jingjing Gong; Thomas J. Prihoda dkk.

Public Library of Science · 2012 · Inggris · PLOS Scopus

Prediction of prostate cancer prognosis is challenging and predictive biomarkers of recurrence remain elusive. Although prostate specific antigen (PSA) has high sensitivity (90%) at a PSA level of 4.0 ng/mL, its low specificity leads to many false positive results and considerable overtreatment of…

Smart distribution network voltage estimation using PMU technology considering zero injection constraints

Swathi Tangi; D. N. Gaonkar; Ramakrishna S. S. Nuvvula dkk.

PLOS ONE, Vol. 19 No. 3 · 2024 · Inggris · PLOS Scopus

To properly control the network of the power system and ensure its protection, Phasor measurement units (PMUs) must be used to monitor the network’s operation. PMUs can provide synchronized real-time measurements. These measurements can be used for state estimation, fault detection and diagnosis…

Improving quality of care for pregnancy, perinatal and newborn care at district and sub-district public health facilities in three districts of Haryana, India: An Implementation study

Manoja Kumar Das; Narendra Kumar Arora; Suresh Kumar Dalpath dkk.

PLOS ONE, Vol. 16 No. 7 · 2021 · Inggris · PLOS Scopus

Introduction: Improving quality of care (QoC) for childbirth and sick newborns is critical for maternal and neonatal mortality reduction. Information on the process and impact of quality improvement at district and sub-district hospitals in India is limited. This implementation research was…

Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India

Manickam Ponnaiah; Sivaraman Ganesan; Tarun Bhatnagar dkk.

PLOS ONE, Vol. 17 No. 8 · 2022 · Inggris · PLOS Scopus

Background: In the ongoing COVID-19 pandemic, an increased incidence of ROCM was noted in India among those infected with COVID. We determined risk factors for rhino-orbito-cerebral mucormycosis (ROCM) post Coronavirus disease 2019 (COVID-19) among those never and ever hospitalized for COVID-19…

Correction: Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India

Manickam Ponnaiah; Sivaraman Ganesan; Tarun Bhatnagar dkk.

PLOS ONE, Vol. 20 No. 4 · 2025 · Inggris · PLOS Scopus

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Wesley C. Van Voorhis; John H. Adams; Roberto Adelfio dkk.

PLOS Pathogens, Vol. 12 No. 7 · 2016 · Inggris · PLOS Scopus

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery…