53 results for "Pathak, Amit"

Scattering of Cell Clusters in Confinement

Pathak, Amit

Biophys J · 2016 · English · PubMed Central

Epithelial-to-mesenchymal transition (EMT) enables scattering of cell clusters and disseminates motile cells to distant locations in vivo during embryonic development and cancer metastasis. Both stiffness and topography of the extracellular matrix (ECM) have been shown to influence EMT. In this…

Search for new physics with baryons at BESIII

Pathak, Amit

arXiv · 2026 · English · arXiv

The BESIII experiment at BEPCII provides a clean environment to test baryon-dark sector connections and baryon-number violation. Using $10^{10}$ $J/ψ$ events, searches were performed for $Σ^{+}\to p+\text{inv}$, $Ξ^{-}\toπ^{-}+\text{inv}$, and $\barΛ-Λ$ oscillations. No excess was observed…

Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration

Pathak, Amit; Kumar, Sanjay

Integr Biol (Camb) · 2013 · English · PubMed Central

It is now well established that tumor cell invasion through tissue is strongly regulated by the microstructural and mechanical properties of the extracellular matrix (ECM). However, it remains unclear how these physical microenvironmental inputs are jointly processed with oncogenic lesions to drive…

Independent regulation of tumor cell migration by matrix stiffness and confinement

Pathak, Amit; Kumar, Sanjay

Proc Natl Acad Sci U S A · 2012 · English · PubMed Central

Tumor invasion and metastasis are strongly regulated by biophysical interactions between tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell migration, adhesion, and contractility has been extensively studied in 2D culture, extension of this concept to 3D…

From Molecular Signal Activation to Locomotion: An Integrated, Multiscale Analysis of Cell Motility on Defined Matrices

Pathak, Amit; Kumar, Sanjay

PLoS One · 2011 · English · PubMed Central

The adhesion, mechanics, and motility of eukaryotic cells are highly sensitive to the ligand density and stiffness of the extracellular matrix (ECM). This relationship bears profound implications for stem cell engineering, tumor invasion and metastasis. Yet, our quantitative understanding of how…

Topographic confinement of epithelial clusters induces epithelial-to-mesenchymal transition in compliant matrices

Nasrollahi, Samila; Pathak, Amit

Sci Rep · 2016 · English · PubMed Central

Epithelial cells disengage from their clusters and become motile by undergoing epithelial-to-mesenchymal transition (EMT), an essential process for both embryonic development and tumor metastasis. Growing evidence suggests that high extracellular matrix (ECM) stiffness induces EMT. In reality…

Epithelial multicellular clustering enabled by polarized macrophages on soft matrices

Zmuda, Hannah; Pathak, Amit

bioRxiv · 2023 · English · PubMed Central

Formation of epithelial structures of variegated geometries and sizes is essential for organogenesis, tumor growth, and wound repair. Although epithelial cells are predisposed with potential for multicellular clustering, it remains unclear whether immune cells and mechanical cues from their…

Also available at: PubMed Central

Emergent depth-mechanosensing of epithelial collectives regulates cell clustering and dispersal on layered matrices

Yu, Hongsheng; Pathak, Amit

Proc Natl Acad Sci U S A · 2025 · English · PubMed Central

During wound healing, tumor growth, and organ formation, epithelial cells migrate and cluster in layered tissue environments. Although cellular mechanosensing of adhered extracellular matrices is now well recognized, it is unclear how deeply cells sense through distant matrix layers. Since single…

Transitions in density, pressure, and effective temperature drive collective cell migration into confining environments

Lin, Wan-Jung; Pathak, Amit

bioRxiv · 2023 · English · PubMed Central

Epithelial cell collectives migrate through tissue interfaces and crevices to orchestrate processes of development, tumor invasion, and wound healing. Naturally, traversal of cell collective through confining environments involves crowding due to the narrowing space, which seems tenuous given the…

Predicting Collective Migration of Cell Populations Defined by Varying Repolarization Dynamics

Mathur, Jairaj; Sarker, Bapi; Pathak, Amit

Biophys J · 2018 · English · PubMed Central

Collective migration of heterogeneous cell populations is an essential aspect of fundamental biological processes, including morphogenesis, wound healing, and tumor invasion. Through experiments and modeling, it has been shown that cells attain front-rear polarity, generate forces, and form…

Reciprocal intra- and extra-cellular polarity enables deep mechanosensing through layered matrices

Walter, Christopher; Mathur, Jairaj; Pathak, Amit

Cell Rep · 2023 · English · PubMed Central

Adherent cells migrate on layered tissue interfaces to drive morphogenesis, wound healing, and tumor invasion. Although stiffer surfaces are known to enhance cell migration, it remains unclear whether cells sense basal stiff environments buried under softer, fibrous matrix. Using layered…

Granulomatous hepatitis in a patient with Crohn's disease and cholestasis

Patedakis Litvinov, Bogdan Ioannis; Pathak, Amit P

BMJ Case Rep · 2017 · English · PubMed Central

We describe a case of a 23-year-old woman with a history of Crohn's disease (CD), who initially presented with sepsis-like symptoms, subsequently developed severe cholestasis and following extensive inpatient workup was found to have non-caseating granulomas on her liver biopsy. Infectious…

Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia

Krull, Carly M; Li, Haiyi; Pathak, Amit

eLife · 2023 · English · PubMed Central

Dynamic nucleocytoplasmic transport of E-M factors regulates cellular E-M states; yet, it remains unknown how simultaneously trapping these factors affects epithelia at the macroscale. To explore this question, we performed nuclear export inhibition (NEI) via leptomycin B and Selinexor treatment…

Gradients in cell density and shape transitions drive collective cell migration into confining environments

Lin, Wan-Jung; Yu, Hongsheng; Pathak, Amit

Soft Matter · 2024 · English · PubMed Central

Epithelial cell collectives migrate through tissue interfaces and crevices to orchestrate development processes, tumor invasion, and wound healing. Naturally, the traversal of cell collective through confining environments involves crowding due to narrowing spaces, which seems tenuous given the…

Imaging of spaces of neck and mediastinum by endoscopic ultrasound

Sharma, Malay; Pathak, Amit; Shoukat, Abid et al.

Lung India · 2016 · English · PubMed Central

Endoscopic ultrasound (EUS) of the mediastinum was pioneered by gastroenterologists, and it was taken up by pulmonologists when the smaller-diameter endobronchial ultrasound (EBUS) scope was designed after a few years. The pulmonologists’ approach remained largely confined to entry from the…

Diagnostic dilemma in gastric varices: Endoscopic ultrasound resolves the issue (with videos)

Sharma, Malay; Singh, Parvinder; Pathak, Amit et al.

Endosc Ultrasound · 2017 · English · PubMed Central

Quetiapine Effective in Treatment of Inappropriate Sexual Behavior of Lewy Body Disease With Predominant Frontal Lobe Signs

Prakash, Ravi; Pathak, Amit; Munda, Sanjay et al.

Am J Alzheimers Dis Other Demen · 2009 · English · PubMed Central

Dementia of Lewy body disease is the second most common degenerative cause of dementia after Alzheimer's disease, among all the dementias. The core features are a progressive dementia, fluctuations in cognitive functions, visual hallucinations, and spontaneous parkinsonism. Rapid eye movement sleep…

Distinct roles of protrusions and collagen deformation in collective invasion of cancer cell types

Lee, Ye Lim; Longmore, Gregory D.; Pathak, Amit

Biophys J · 2025 · English · PubMed Central

The breast tumor microenvironment is composed of heterogeneous cell populations, including normal epithelial cells, cancer-associated fibroblasts (CAFs), and tumor cells that lead collective cell invasion. Both leader tumor cells and CAFs are known to play important roles in tumor invasion across…

Blind areas of cardiac imaging during transesophageal echocardiogram/endoscopic ultrasound

Sharma, Malay; Pathak, Amit; Shoukat, Abid et al.

Endosc Ultrasound · 2017 · English · PubMed Central