41 hasil untuk "Pavan, Alberto"
Menampilkan 1–20 · 0,68 detik · RSS
-
Artikel Jurnal Teks lengkap
Assessment of chromosomal rearrangements helps to differentiate multiple lung primary cancers from metastases
-
Artikel Jurnal Teks lengkap
LKB1 and Tumor Metabolism: The Interplay of Immune and Angiogenic Microenvironment in Lung Cancer
Liver kinase B1 (LKB1) is a tumor suppressor gene whose inactivation is frequent in different tumor types, especially in lung adenocarcinoma (about 30% of cases). LKB1 has an essential role in the control of cellular redox homeostasis by regulating ROS production and detoxification. Loss of LKB1…
-
Artikel Jurnal Teks lengkap
Subacute Cutaneous Lupus Erythematosus-Like Eruption Induced by EGFR -Tyrosine Kinase Inhibitor in EGFR-Mutated Non-small Cell Lung Cancer: A Case Report
EGFR tyrosine kinase inhibitors (TKIs) are the front-line treatment in EGFR mutation positive advanced non-small cell lung cancer (aNSCLC) patients. Generally, they are well-tolerated but skin toxicity is common (45–100% of patients) and may adversely affect quality of life. Pathogenesis of…
-
Artikel Jurnal Teks lengkap
Detection of Loss of Heterozygosity in cfDNA of Advanced EGFR- or KRAS-Mutated Non-Small-Cell Lung Cancer Patients
Liquid biopsy is currently approved for management of epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) patients. However, one unanswered question is whether the rate of cell-free DNA (cfDNA)-negative samples is due to technical limitations rather than to tumor…
-
Artikel Jurnal Teks lengkap
Clinical Impact of Plasma and Tissue Next‐Generation Sequencing in Advanced Non‐Small Cell Lung Cancer: A Real‐World Experience
BACKGROUND: Targeted agents have improved the outcome of a subset of non‐small cell lung cancer (NSCLC). Molecular profiling by next‐generation sequencing (NGS) allows screening for multiple genetic alterations both in tissue and in plasma, but limited data are available concerning its feasibility…
-
Artikel Jurnal Teks lengkap
Real-Life Comparison of Diagnostic Yield and Sample Adequacy of 22 G and 25 G EBUS-TBNB Needles: A Retrospective Study
Background/Objectives: EBUS-TBNA is a safe and minimally invasive procedure to evaluate hilar and mediastinal lymph nodes (LNs). The Franseen needle provides a transbronchial needle biopsy (TBNB). Various needle sizes are available. In the literature, diagnostic yield (DY) and sample adequacy (SA)…
-
Buku Teks lengkap
Innovative Tools and Methods Using BIM for an Efficient Renovation in Buildings
This open access book describes a BIM-based toolkit that has been developed according to the latest research activities on building information modelling and semantic interoperability to optimize the building process. It highlights the impacts of using such new tools to fast renovation activities…
Juga tersedia di: DOAB
-
Artikel Jurnal Teks lengkap
Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
The possibility to analyse the tumour genetic material shed in the blood is undoubtedly one of the main achievements of translational research in the latest years. In the modern clinical management of advanced non-small cell lung cancer, molecular characterisation plays an essential role. In…
-
Artikel Jurnal Teks lengkap
Immune-related adverse events in patients treated with immunotherapy for locally advanced or metastatic NSCLC in real-world settings: a systematic review and meta-analysis
INTRODUCTION: Randomized clinical trials (RCTs) represent the mainstay for the approval of new treatments. However, stringent inclusion criteria often cause them to depart from the daily clinical practice. Real-world (RW) evidence have a complementing role, filling the gap between the efficacy of a…
-
Artikel Jurnal Teks lengkap
Peripheral Blood Markers Identify Risk of Immune‐Related Toxicity in Advanced Non‐Small Cell Lung Cancer Treated with Immune‐Checkpoint Inhibitors
BACKGROUND. Immune‐checkpoint inhibitors (ICIs) are now standard of care for advanced non‐small cell lung cancer (NSCLC). Unfortunately, many patients experience immune‐related adverse events (irAEs), which are usually mild and reversible, but they require timely management and may be life…
-
Artikel Jurnal Teks lengkap
Longitudinal liquid biopsy predicts clinical benefit from immunotherapy in advanced non-small cell lung cancer
High heterogeneity in clinical benefit characterizes the use of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC). We prospectively enrolled 113 advanced NSCLC patients treated with ICIs and performed liquid biopsy at the time of ICI start (T1), after 3 weeks (T2) and at the…
-
Bab Buku Teks lengkap
Chapter Digital Transformation in the Construction Sector: From BIM to Digital Twin
undefined
-
Bab Buku Teks lengkap
Chapter An Automated Framework for Ensuring Information Consistency in Price List Tendering Document
Effective cost estimation for tendering plays a critical role in the building construction process, enabling efficient investment management and ensuring successful execution of the construction phase. Traditional cost estimation procedure involves manual information processing to extract and match…
-
Bab Buku Teks lengkap
Chapter Semantic Web Based Integration Between BIM Cost and Geometric Domains
In the architecture, engineering, construction, and facilities management (AEC/FM) industry methodologies are needed to ensure the interoperability of data and effective management of information from different sources. Integration of the cost domain and cost estimation within the Building…
Juga tersedia di: OAPEN
-
Artikel Jurnal Teks lengkap
Tumor Immune-Infiltrate Landscape After Chemo-Radiotherapy in a Case Series of Patients with Non-small Cell Lung Cancer: Pretreatment Predictors and Correlation With Outcome
INTRODUCTION: Data on tumor immune-milieu after chemo-radiation (CT-RT) are scarce. Noninvasive tools are needed to improve the treatment of non–small cell lung cancer (NSCLC), especially in the locally advanced (LA) setting. METHODS: We collected a series of superior-sulcus (SS)- patients with…
-
Artikel Jurnal Teks lengkap
Extensive-stage small-cell lung cancer in patients receiving atezolizumab plus carboplatin–etoposide: stratification of outcome based on a composite score that combines gene expression profiling and immune characterization of microenvironment
PURPOSE: Small-cell lung cancer (SCLC) is an aggressive disease with a dismal prognosis. The addition of immune checkpoints inhibitors to standard platinum-based chemotherapy in first-line setting achieves a durable benefit only in a patient subgroup. Thus, the identification of predictive…