40 hasil untuk "Pavan Kumar"
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Artikel Jurnal Teks lengkap
Discovery and characterization of anti-cancer peptides from a random peptide library
We performed a forward genetic screen to discover peptides that specifically target breast cancer cells using a Penetratin tagged, random 15mer peptide library. We identified a group of novel peptides that specifically inhibited the proliferation and survival of breast cancer cells without…
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Artikel Jurnal Teks lengkap
Tobacco Rattle Virus Vector: A Rapid and Transient Means of Silencing Manduca sexta Genes by Plant Mediated RNA Interference
Background: RNAi can be achieved in insect herbivores by feeding them host plants stably transformed to express double stranded RNA (dsRNA) of selected midgut-expressed genes. However, the development of stably transformed plants is a slow and laborious process and here we developed a rapid…
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Artikel Jurnal Teks lengkap
Myopia progression varies with age and severity of myopia
Objective: To investigate annual myopia progression in individuals from South Indian states across different age groups, and its association with age of onset and severity of myopia. Methods: This retrospective study included the data of 6984 myopes (range: 1–30 years), who visited at least twice…
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Artikel Jurnal Teks lengkap
Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment
Background: The immune response to tuberculosis (TB) is T cell dependent. T cells are the major facilitators of protection and effector functions with CD4+ T cells being the most important players, followed by CD8+ T cells. The common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 play a vital role…
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Artikel Jurnal Teks lengkap
Circulating Angiogenic Factors as Biomarkers of Disease Severity and Bacterial Burden in Pulmonary Tuberculosis
Background: Angiogenesis and lymphangiogenesis are classical features of granuloma formation in pulmonary tuberculosis (PTB). In addition, the angiogenic factor—VEGF-A is a known biomarker for PTB. Aims/Methodology: To examine the association of circulating angiogenic factors with PTB, we examined…
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Artikel Jurnal Teks lengkap
Ambient light level varies with different locations and environmental conditions: Potential to impact myopia
Purpose: Considering that time spent outdoors is protective for myopia, we investigated how ambient light levels reaching the eye varies across 9 outdoor and 4 indoor locations in 5 different environmental conditions. Methods: Illuminance (lux) was recorded using a lux meter under conditions of…
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Artikel Jurnal Teks lengkap
Prediabetes is associated with the modulation of antigen-specific Th1/Tc1 and Th17/Tc17 responses in latent Mycobacterium tuberculosis infection
Type 2 diabetes mellitus (DM) is associated with the down modulation of Th1, Th2 and Th17 responses in latent Mycobacterium tuberculosis infection but the role of prediabetes (PDM) in this setting is not well understood. To examine the role of CD4+ and CD8+ T cell cytokines in latent tuberculosis…
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Artikel Jurnal Teks lengkap
Differences in Nicotine Metabolism of Two Nicotiana attenuata Herbivores Render Them Differentially Susceptible to a Common Native Predator
Background: Nicotiana attenuata is attacked by larvae of both specialist (Manduca sexta) and generalist (Spodoptera exigua) lepidopteran herbivores in its native habitat. Nicotine is one of N. attenuata's important defenses. M. sexta is highly nicotine tolerant; whether cytochrome P450…
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Artikel Jurnal Teks lengkap
Association of Climatic Variability, Vector Population and Malarial Disease in District of Visakhapatnam, India: A Modeling and Prediction Analysis
Background: Malarial incidence, severity, dynamics and distribution of malaria are strongly determined by climatic factors, i.e., temperature, precipitation, and relative humidity. The objectives of the current study were to analyse and model the relationships among climate, vector and malaria…
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Artikel Jurnal Teks lengkap
Altered systemic levels of acute phase proteins in tuberculous lymphadenitis and modulation after treatment
Background: Pulmonary tuberculosis (PTB) is characterized by elevated levels of acute phase proteins (APPs), but their association with tuberculous lymphadenitis (TBL) is poorly studied. Methods: We examined the systemic levels of APPs (alpha-2-macroglobulin [⍺-2MG], serum amyloid A [SAA]…
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Calculating forest species diversity with information-theory based indices using sentinel-2A sensor’s of Mahavir Swami Wildlife Sanctuary
Tropical forest serves as an important pivotal role in terrestrial biological diversity. The present study makes an attempt to identify the concentration of species among tree diversity in Mahavir Swami Wildlife Sanctuary, Bundelkhand, India. Four important ecological indicator indices namely…
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Artikel Jurnal Teks lengkap
Evidence of Microbial Translocation Associated with Perturbations in T Cell and Antigen-Presenting Cell Homeostasis in Hookworm Infections
Background: Microbial translocation (MT) is the process by which microbes or microbial products translocate from the intestine to the systemic circulation. MT is a common cause of systemic immune activation in HIV infection and is associated with reduced frequencies of CD4+ T cells; no data exist…
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Artikel Jurnal Teks lengkap
Triglyceride/HDL Ratio as a Screening Tool for Predicting Success at Reducing Anti-Diabetic Medications Following Weight Loss
Background and Objectives: Intentional weight loss, by reducing insulin resistance, results in both better glycemic control and decreased need for anti-diabetic medications. However, not everyone who is successful with weight loss is able to reduce anti-diabetic medication use. In this…
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Artikel Jurnal Teks lengkap
RNA-Seq Based Transcriptome Analysis of Hepatitis E Virus (HEV) and Hepatitis B Virus (HBV) Replicon Transfected Huh-7 Cells
Pathogenesis of hepatitis B virus (HBV) and hepatitis E virus (HEV) infection is as varied as they appear similar; while HBV causes an acute and/or chronic liver disease and hepatocellular carcinoma, HEV mostly causes an acute self-limiting disease. In both infections, host responses are crucial in…
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Artikel Jurnal Teks lengkap
Heightened circulating levels of antimicrobial peptides in tuberculosis—Diabetes co-morbidity and reversal upon treatment
Background: The association of antimicrobial peptides (AMPs) with tuberculosis—diabetes comorbidity (PTB-DM) is not well understood. Methods: To study the association of AMPs with PTB-DM, we examined the systemic levels of cathelicidin (LL37), human beta defensin– 2 (HBD2), human neutrophil…
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Artikel Jurnal Teks lengkap
Decreased Frequencies of Circulating CD4 + T Follicular Helper Cells Associated with Diminished Plasma IL-21 in Active Pulmonary Tuberculosis
Background: Circulating T follicular helper (Tfh) cells represent a distinct subset of CD4+ T cells and are important in immunity to infections. Although they have been shown to play a role in experimental models of tuberculosis infection, their role in human tuberculosis remains unexplored…
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Artikel Jurnal Teks lengkap
Identification and Characteristics of microRNAs from Army Worm, Spodoptera frugiperda Cell Line Sf21
microRNAs play important regulatory role in all intrinsic cellular functions. Amongst lepidopteran insects, miRNAs from only Bombyx mori have been studied extensively with a little focus on Spodoptera sp. In the present study, we identified a total of 226 miRNAs from Spodoptera frugiperda cell line…
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Artikel Jurnal Teks lengkap
Cost-effectiveness of virtual emergency care models: A protocol for a systematic review
Background: The COVID-19 pandemic has accelerated the adoption of virtual care models in emergency medicine. While virtual emergency care has the potential to expand access, improve efficiency, and reduce costs, rigorous evaluation of its cost-effectiveness compared with traditional in-person…
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Artikel Jurnal Teks lengkap
Coincident Pre-Diabetes Is Associated with Dysregulated Cytokine Responses in Pulmonary Tuberculosis
Background: Cytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB) - Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known. Methods: To identify the influence of coincident PDM…
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Artikel Jurnal Teks lengkap
Integrative taxonomy of the genus Coridius Illiger, 1807 (Hemiptera: Heteroptera: Dinidoridae) reveals hidden diversity and three new species from North-East India
The genus Coridius Illiger, 1807 (Heteroptera: Dinidoridae) comprises a group of phytophagous terrestrial bugs consisting of 36 species distributed in the Afrotropical and Indo-Malayan regions. In several communities in northeastern India, insects are recognised as a delicacy, medicine, and a…