6 results for "Peter Proff"

Housekeeping gene validation for RT-qPCR studies on synovial fibroblasts derived from healthy and osteoarthritic patients with focus on mechanical loading

Ute Nazet; Agnes Schröder; Susanne Grässel et al.

PLOS ONE, Vol. 14 No. 12 · 2019 · English · PLOS Scopus

Selection of appropriate housekeeping genes is essential for the validity of data normalization in reverse transcription quantitative PCR (RT-qPCR). Synovial fibroblasts (SF) play a mediating role in the development and progression of osteoarthritis (OA) pathogenesis, but there is no information on…

Effects of histamine on human periodontal ligament fibroblasts under simulated orthodontic pressure

Marcella Groeger; Gerrit Spanier; Michael Wolf et al.

PLOS ONE, Vol. 15 No. 8 · 2020 · English · PLOS Scopus

As type-I-allergies show an increasing prevalence in the general populace, orthodontic patients may also be affected by histamine release during treatment. Human periodontal ligament fibroblasts (PDLF) are regulators of orthodontic tooth movement. However, the impact of histamine on PDLF in this…

Investigating a potential association between agenesis of the third molars and variations in dental crown dimensions

Gloria Guht; Christian Kirschneck; Nikolaos Daratsianos et al.

PLOS One, Vol. 21 No. 5 · 2026 · English · PLOS Scopus

The aim of this study was to investigate the association between third molar agenesis and mesiodistal crown dimensions in individuals from Germany. The sample consisted of 314 (156 males and 158 females) orthodontic patients, divided into two groups: one group with individuals presenting at least…

Correction: The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients

Iago Ramirez; Christian Kirschneck; Alice C Silva-Sousa et al.

PLOS ONE, Vol. 19 No. 6 · 2024 · English · PLOS Scopus

The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients

Iago Ramirez; Christian Kirschneck; Alice Corrêa Silva-Sousa et al.

PLOS ONE, Vol. 18 No. 8 · 2023 · English · PLOS Scopus

The aim of this study is to evaluate if single nucleotide polymorphisms (SNPs) in WNT6 and WNT10A are associated with the risk of dental pulp calcification in orthodontic patients. This cross-sectional study followed the “Strengthening the Reporting of Genetic Association Studies” (STREGA)…

Fibroblast growth factor receptor 2 ( FGFR2 ) genetic polymorphisms contribute to fused roots in human molars

Sandra Regina Santos Meyfarth; Flares Baratto-Filho; Maria Eduarda Nunis Locks et al.

PLOS ONE, Vol. 20 No. 4 · 2025 · English · PLOS Scopus

Fibroblast growth factors (FGFRs) signaling are required for human tooth development. Its dysregulation affects tooth formation and patients with FGFR2 mutations often present dental anomalies in the spectrum of the syndrome. This study aimed to investigate whether genetic polymorphisms in FGFR2…