74 results for "Ping Lin"
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Dyskerin Localizes to the Mitotic Apparatus and Is Required for Orderly Mitosis in Human Cells
Dyskerin is a highly conserved, nucleolar RNA-binding protein with established roles in small nuclear ribonucleoprotein biogenesis, telomerase and telomere maintenance and precursor rRNA processing. Telomerase is functional during S phase and the bulk of rRNA maturation occurs during G1 and S…
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Parameter identification of sound absorption model of porous materials based on modified particle swarm optimization algorithm
Porous materials have been widely used in the field of noise control. The non-acoustical parameters involved in the sound absorption model have an important effect on the sound absorption performance of porous materials. How to identify these non-acoustical parameters efficiently and accurately is…
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A phase-field model for vesicle membranes incorporating area-difference elasticity
This paper presents a phase-field model for simulating the three-dimensional deformation of vesicle membranes, incorporating area-difference elasticity (i.e., the elasticity arising from the difference between the inner and outer lipid leaflets), with constraints on bulk volume and surface area. We…
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Risk factors for depression in asthmatic individuals: Findings from NHANES (2005–2018)
Background: The risk factors for depression in asthma are still unclear. The objective of this study was to identify the risk factors associated with depression in asthmatic individuals. Methods: We used data from the 2005–2018 National Health and Nutrition Examination Survey (NHANES). Univariate…
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Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies
Sirtuins are key regulators of many cellular functions including cell growth, apoptosis, metabolism, and genetic control of age-related diseases. Sirtuins are themselves regulated by their cofactor nicotinamide adenine dinucleotide (NAD+) as well as their reaction product nicotinamide (NAM), the…
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An overview of GabRat edge disruption and its new extensions for unbiased quantification of disruptive camouflaging patterns using randomization technique
Disruptive colorations are camouflaging patterns that use contrasting colorations to interrupt the continuity of object’s edge and disturb the observer’s visual recognition. The GabRat method has been introduced and widely used to quantify the strength of edge disruption. The original GabRat method…
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Caffeic Acid Phenethyl Ester Causes p21 Cip1 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells
Caffeic acid phenethyl ester (CAPE) treatment suppressed proliferation, colony formation, and cell cycle progression in PC-3 human prostate cancer cells. CAPE decreased protein expression of cyclin D1, cyclin E, SKP2, c-Myc, Akt1, Akt2, Akt3, total Akt, mTOR, Bcl-2, Rb, as well as phosphorylation…
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How does Confucian culture affect technological innovation? Evidence from family enterprises in China
Culture is one of the crucial elements of technological innovation. The existing studies hold that Confucian culture is conducive to the technological innovation of Chinese Listed Companies. However, Chinese family enterprises with relatively profound Confucianism encounter the bottleneck of weak…
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Integrative species delimitation and five new species of lynx spiders (Araneae, Oxyopidae) in Taiwan
An accurate assessment of species diversity is a cornerstone of biology and conservation. The lynx spiders (Araneae: Oxyopidae) represent one of the most diverse and widespread cursorial spider groups, however their species richness in Asia is highly underestimated. In this study, we revised…
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Comparative transcriptomics reveals specific responding genes associated with atherosclerosis in rabbit and mouse models
Mouse and rabbit are frequently employed species for atherosclerosis research. With respect to modeling human atherosclerosis, it has been observed that variations in phenotype under commonly used atherogenic conditions are partial or no congruence between two species. However, genome-wide…
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Demonstration of disinfection procedure for the development of accurate blood glucose meters in accordance with ISO 15197:2013
Despite measures to reduce disease transmission, a risk can occur when blood glucose meters (BGMs) are used on multiple individuals or by caregivers assisting a patient. The laboratory and in-clinic performance of a BGM system before and after disinfection should be demonstrated to guarantee…
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In Vitro and In Vivo Studies on Protective Action of N -Phenethyl Caffeamide against Photodamage of Skin
In our previous study, N-phenethyl caffeamide (K36) was proved to act as an antioxidant and an antiphotoaging agent by inhibiting type I procollagen degradation and stimulating collagen synthesis in human skin fibroblasts. In the present study, in vitro and in vivo experiments were conducted to…
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Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death
Bacterial pathogens and their toxins target host receptors, leading to aberrant behavior or host death by changing signaling events through subversion of host intracellular cAMP level. This is an efficient and widespread mechanism of microbial pathogenesis. Previous studies describe toxins that…
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Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas
Helium, a minor component of natural gas and radioactive minerals, is most commonly used as a carrier in gas chromatography-mass spectrometry (GC-MS). Its scarcity leads to limited availability and higher costs. In this experiment, hydrogen from a safe source of a hydrogen generator was tested as a…
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Predictive modeling of gene mutations for the survival outcomes of epithelial ovarian cancer patients
Epithelial ovarian cancer (EOC) has a low overall survival rate, largely due to frequent recurrence and acquiring resistance to platinum-based chemotherapy. EOC with homologous recombination (HR) deficiency has increased sensitivity to platinum-based chemotherapy because platinum-induced DNA damage…
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The AF-2 domain of estrogen-related receptor interacts with PPRC1 to modulate larval epidermal marking in Bombyx mori
Estrogen-related receptors (ERRs) have no natural ligands, vertebrate ERRs rely on their activation function-2 (AF-2) structural domain to recruit coactivators for transcriptional regulation. While metabolic regulation in insects differs significantly from that in vertebrates, it remains unclear…
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Aldosterone and Mortality in Hemodialysis Patients: Role of Volume Overload
Background: Elevated aldosterone is associated with increased mortality in the general population. In patients on dialysis, however, the association is reversed. This paradox may be explained by volume overload, which is associated with lower aldosterone and higher mortality. Methods: We evaluated…
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Endothelial-derived extracellular matrix ameliorate the stemness deprivation during ex vivo expansion of mouse bone marrow-derived mesenchymal stem cells
Mesenchymal stem cells (MSCs) hold great potential in cell therapies by virtue of the regenerative effects and immunomodulatory properties, but the scarce nature of MSCs makes ex vivo expansion indispensable prior to transplantation purposes. However, potential loss of stemness ensuing culture…