59 hasil untuk "Prashanth"

Function, Structure, and Stability of Enzymes Confined in Agarose Gels

Jeffrey Kunkel; Prashanth Asuri

PLoS ONE, Vol. 9 No. 1 · 2014 · Inggris · PLOS Scopus

Research over the past few decades has attempted to answer how proteins behave in molecularly confined or crowded environments when compared to dilute buffer solutions. This information is vital to understanding in vivo protein behavior, as the average spacing between macromolecules in the cell…

Susceptibility to Superhelically Driven DNA Duplex Destabilization: A Highly Conserved Property of Yeast Replication Origins

Prashanth Ak; Craig J Benham

PLoS Computational Biology, Vol. 1 No. 1 · 2005 · Inggris · PLOS Scopus

Strand separation is obligatory for several DNA functions, including replication. However, local DNA properties such as A+T content or thermodynamic stability alone do not determine the susceptibility to this transition in vivo. Rather, superhelical stresses provide long-range coupling among the…

The Rate of Decline in Small Fibre Function Assessed Using Axon Reflex-Mediated Neurogenic Vasodilatation and the Importance of Age Related Centile Values to Improve the Detection of Clinical Neuropathy

Prashanth R. J. Vas; Gerry Rayman

PLoS ONE, Vol. 8 No. 7 · 2013 · Inggris · PLOS Scopus

Background: The LDIflare technique (LDIflare) is a simple non-invasive test of small fibre function in dorsal foot skin involving skin heating and measuring the size of the resulting axon reflex-mediated vasodilator (flare) response using a laser Doppler imager (LDI). This study establishes…

Multitask deep learning for the emulation and calibration of an agent-based malaria transmission model

Agastya Mondal; Rushil Anirudh; Prashanth Selvaraj

PLOS Computational Biology, Vol. 21 No. 7 · 2025 · Inggris · PLOS Scopus

Agent-based models of malaria transmission are useful tools for understanding disease dynamics and planning interventions, but they can be computationally intensive to calibrate. We present a multitask deep learning approach for emulating and calibrating a complex agent-based model of malaria…

Confusion2Vec 2.0: Enriching ambiguous spoken language representations with subwords

Prashanth Gurunath Shivakumar; Panayiotis Georgiou; Shrikanth Narayanan

PLOS ONE, Vol. 17 No. 3 · 2022 · Inggris · PLOS Scopus

Word vector representations enable machines to encode human language for spoken language understanding and processing. Confusion2vec, motivated from human speech production and perception, is a word vector representation which encodes ambiguities present in human spoken language in addition to…

A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration

Mark-Phillip Pebworth; Sabrina A. Cismas; Prashanth Asuri

PLoS ONE, Vol. 9 No. 10 · 2014 · Inggris · PLOS Scopus

Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness. To better understand the effects of stiffness…

PROMPTa—A multifaceted assessment approach to develop writing skills

Vezolu Puro; Noel Anurag Prashanth Nittala; Hariharasudan A

PLOS One, Vol. 20 No. 12 · 2025 · Inggris · PLOS Scopus

Assessment plays a pivotal role in developing writing skills, yet traditional teacher-led evaluations often fall short in addressing learner’s diverse needs, creating a substantial gap in effective writing methodologies. Lack of evidence-based studies to measure the effectiveness of assistive…

Policymakers’ concerns linking tobacco and Indigenous communities in India: A qualitative analysis of parliamentary questions (1952–2022)

Shilpi Sikha Das; Upendra Bhojani; Nugehalli Srinivas Prashanth

PLOS Global Public Health, Vol. 6 No. 2 · 2026 · Inggris · PLOS Scopus

Tobacco use and associated disease burden remain high among Indigenous communities in India. Despite an overall decline in tobacco consumption over the last few decades, the social disparities in tobacco use have widened, with Indigenous communities experiencing the least decline. Existing tobacco…

Using tears as a non-invasive source for early detection of breast cancer

Anna Daily; Prashanth Ravishankar; Steve Harms dkk.

PLOS ONE, Vol. 17 No. 4 · 2022 · Inggris · PLOS Scopus

The changing expression levels of ocular proteins in response to systemic disease has been well established in literature. In this study, we examined the ocular proteome to identify protein biomarkers with altered expression levels in women diagnosed with breast cancer. Tear samples were collected…

Mapping the rare disease stakeholders in India

Mohua Chakraborty Choudhury; Jerry Philip George; Prashanth N. Srinivas

PLOS Global Public Health, Vol. 6 No. 3 · 2026 · Inggris · PLOS Scopus

Rare diseases (RD) are not rare collectively, affecting around 300 million people globally and 96 million in India. These diseases have not been prioritized in most low- and middle-income countries’ health policies. India launched its first functional RD policy in 2021. Successful policy…

Understanding the influence of power dynamics in intersectoral collaboration: A realist evaluation in Assam, India

Praveenkumar Aivalli; Brynne Gilmore; Prashanth Nuggehalli Srinivas dkk.

PLOS Global Public Health, Vol. 5 No. 12 · 2025 · Inggris · PLOS Scopus

Intersectoral Collaboration (ISC) involves multiple sectors working together to tackle complex challenges that no single sector can address alone. In global health, where interconnected issues demand holistic approaches, ISC aligns goals and resources to enhance effectiveness and equity. However…

A switch in the mode of Wnt signaling orchestrates the formation of germline stem cell differentiation niche in Drosophila

Maitreyi Upadhyay; Michael Kuna; Sara Tudor dkk.

PLOS Genetics, Vol. 14 No. 1 · 2018 · Inggris · PLOS Scopus

Germline stem cell (GSC) self-renewal and differentiation into gametes is regulated by both intrinsic factors in the germ line as well as extrinsic factors from the surrounding somatic niche. dWnt4, in the escort cells of the adult somatic niche promotes GSC differentiation using the canonical…

Correction: Validation of ToucHb, a non-invasive haemoglobin estimation: Effective for normal ranges, needs improvement for anaemia detection

Yogish Channa Basappa; Sumanth Mallikarjuna Majgi; Shashidhar Byrappa Hanumanahally dkk.

PLOS Global Public Health, Vol. 4 No. 12 · 2024 · Inggris · PLOS Scopus

Validation of ToucHb, a non-invasive haemoglobin estimation: Effective for normal ranges, needs improvement for anaemia detection

Yogish Channa Basappa; Sumanth Mallikarjuna Majgi; Shashidhar Byrappa Shashidhar dkk.

PLOS Global Public Health, Vol. 4 No. 3 · 2024 · Inggris · PLOS Scopus

Non-invasive methods for haemoglobin estimation hold enormous potential for early detection and treatment of anaemia, especially in limited resource settings. We sought to validate the diagnostic accuracy of ToucHb, a non-invasive haemoglobin estimation device available in the Indian market. We…

Factors Controlling the Redox Potential of ZnCe 6 in an Engineered Bacterioferritin Photochemical ‘Reaction Centre’

Abdullah Mahboob; Serguei Vassiliev; Prashanth K. Poddutoori dkk.

PLoS ONE, Vol. 8 No. 7 · 2013 · Inggris · PLOS Scopus

Photosystem II (PSII) of photosynthesis has the unique ability to photochemically oxidize water. Recently an engineered bacterioferritin photochemical ‘reaction centre’ (BFR-RC) using a zinc chlorin pigment (ZnCe6) in place of its native heme has been shown to photo-oxidize bound manganese ions…

The influence of age, anthropometric and metabolic variables on LDI FLARE and corneal confocal microscopy in healthy individuals

Sanjeev Sharma; Victoria Tobin; Prashanth R. J. Vas dkk.

PLOS ONE, Vol. 13 No. 3 · 2018 · Inggris · PLOS Scopus

Introduction: The laser Doppler imaging (LDI) FLARE and corneal confocal microscopy (CCM) are reliable markers of small fibre function (SFF) and structure (SFS), respectively, but the impact of potential confounding variables needs to be defined. The objective of this study was to determine the…

Modelling the impact of mosquito bed net utilization on malaria transmission and evolution of pyrethroid resistance

Ivan Sseguya; Joseph Y. T. Mugisha; Juliet N. Nakakawa dkk.

PLOS One, Vol. 21 No. 7 · 2026 · Inggris · PLOS Scopus

Long-lasting Insecticide Nets (LLINs) are central to malaria prevention, but their effectiveness is threatened by the increasing pyrethroid resistance and low bed net utilization in malaria-endemic regions globally. This study formulates a genotype-specific compartmental model accounting for…

Transcriptome-wide comparison of the impact of Atoh1 and miR-183 family on pluripotent stem cells and multipotent otic progenitor cells

Michael Ebeid; Prashanth Sripal; Jason Pecka dkk.

PLOS ONE, Vol. 12 No. 7 · 2017 · Inggris · PLOS Scopus

Over 5% of the global population suffers from disabling hearing loss caused by multiple factors including aging, noise exposure, genetic predisposition, or use of ototoxic drugs. Sensorineural hearing loss is often caused by the loss of sensory hair cells (HCs) of the inner ear. A barrier to…

Restoration of Spermatogenesis and Male Fertility Using an Androgen Receptor Transgene

William H. Walker; Evan Easton; Rebecca S. Moreci dkk.

PLOS ONE, Vol. 10 No. 3 · 2015 · Inggris · PLOS Scopus

Androgens signal through the androgen receptor (AR) to regulate male secondary sexual characteristics, reproductive tract development, prostate function, sperm production, bone and muscle mass as well as body hair growth among other functions. We developed a transgenic mouse model in which…

Expression of the amyloid-β peptide in a single pair of C . elegans sensory neurons modulates the associated behavioural response

Tessa Sinnige; Prashanth Ciryam; Samuel Casford dkk.

PLOS ONE, Vol. 14 No. 5 · 2019 · Inggris · PLOS Scopus

Although the aggregation of the amyloid-β peptide (Aβ) into amyloid fibrils is a well-established hallmark of Alzheimer’s disease, the complex mechanisms linking this process to neurodegeneration are still incompletely understood. The nematode worm C. elegans is a valuable model organism through…