7 hasil untuk "Puralewski, Rachel"
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Artikel Jurnal Teks lengkap
Sex-related factors influence expression of mood-related genes in the basolateral amygdala differentially depending on age and stress exposure
BACKGROUND: Women are twice as likely to be diagnosed with major depressive disorder (MDD) compared to men, but the molecular mechanisms underlying this sex difference are unclear. Previous studies in the human postmortem brain suggest dysfunction in basolateral amygdala (BLA) inhibitory…
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When the science alone is not enough: embracing our responsibility as science communicators
The US biomedical research enterprise has led the world in driving medicine forward but now faces unprecedented threats. Systematic efforts to defund and dismantle the academic research infrastructure, compounded by misinformation and questionable public support for science, have already impeded…
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Artikel Jurnal Teks lengkap
The Development of Trait Anxiety in Nonhuman Primates During the First Year of Life
Anxious temperament (AT) is a nonhuman primate phenotype that models childhood behavioral inhibition, a prominent risk factor for anxiety disorders and stress‐related psychopathology. To understand its earliest antecedents, we characterized AT's developmental trajectory over the first year of life…
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FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk
The A allele of the FRAS1-related extracellular matrix protein 3 (FREM3) rs7676614 single nucleotide polymorphism (SNP) was linked to major depressive disorder (MDD) in an early genome-wide association study (GWAS), and to symptoms of psychomotor retardation in a follow-up investigation. In line…
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Artikel Jurnal Teks lengkap
Opposite molecular signatures of depression in men and women
BACKGROUND: Major depressive disorder (MDD) affects women approximately twice as often as men. Women are three times as likely to have atypical depression, with hypersomnia and weight gain. This suggests that the molecular mechanisms of MDD may differ by sex. METHODS: To test this hypothesis, we…
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Artikel Jurnal Teks lengkap
Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry
Women are approximately two times as likely to be diagnosed with major depressive disorder (MDD) compared to men. While sex differences in MDD might be driven by circulating gonadal hormones, we hypothesized that developmental hormone exposure and/or genetic sex might play a role. Mice were…
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Artikel Jurnal Teks lengkap
Older Molecular Brain Age in Severe Mental Illness
Psychiatric disorders are associated with accelerated aging and enhanced risk for neurodegenerative disorders. Brain aging is associated with molecular, cellular and structural changes that are robust on the group-level, yet show substantial inter-individual variability. Here we assessed deviations…