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2 results for "Robbie Loewith"

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  1. Journal Article Full text

    Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

    Morris E Feldman; Beth Apsel; Aino Uotila et al.

    PLoS Biology, Vol. 7 No. 2 · 2009 · English · PLOS Scopus

    The mammalian target of rapamycin (mTOR) regulates cell growth and survival by integrating nutrient and hormonal signals. These signaling functions are distributed between at least two distinct mTOR protein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to the selective inhibitor rapamycin and…

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  2. Journal Article Full text

    A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast

    Michael A. Kennedy; Kenneth Gable; Karolina Niewola-Staszkowska et al.

    PLoS Genetics, Vol. 10 No. 1 · 2014 · English · PLOS Scopus

    Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0) which is associated with neurotoxicity. Similar…

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