3 hasil untuk "Samuel Lessard"
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Artikel Jurnal Teks lengkap
Frameshift indels introduced by genome editing can lead to in-frame exon skipping
The introduction of frameshift indels by genome editing has emerged as a powerful technique to study the functions of uncharacterized genes in cell lines and model organisms. Such mutations should lead to mRNA degradation owing to nonsense-mediated mRNA decay or the production of severely truncated…
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Artikel Jurnal Teks lengkap
Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients
DNA methylation is believed to regulate gene expression during adulthood in response to the constant changes in environment. The methylome is therefore proposed to be a biomarker of health through age. ANGPTL2 is a circulating pro-inflammatory protein that increases with age and prematurely in…
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Artikel Jurnal Teks lengkap
Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease
Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications of sickle cell disease (SCD), including stroke. However, little information exists on the association and interactions for the common African ancestral α-thalassemia mutation (−α3.7 deletion) and…