19 hasil untuk "Sayed, Samir"
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Artikel Jurnal Teks lengkap
The Fourth Wave of the COVID-19 in Afghanistan: The Way Forward
The COVID-19 pandemic hit Afghanistan at a time when the country was most vulnerable, with a fragile healthcare system and unable to contain the disease, and meet the needs of the vulnerable people. The country has gone through four waves of the disease thus far. An analysis of the COVID-19 cases…
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Post‐COVID‐19 fatigue and anhedonia: A cross‐sectional study and their correlation to post‐recovery period
BACKGROUND: Individuals infected by the novel coronavirus (SARS‐CoV‐2) have experienced different psychiatric manifestations during the period of infectivity and post‐COVID‐19 infection. Fatigue and anhedonia are among the frequently reported manifestations after recovery from this novel viral…
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Pandemic Grief Scale in detection of grief reaction among physicians in COVID-19 era
BACKGROUND: Physicians are considered one of the most vulnerable groups who might develop pandemic grief during this critical time of COVID-19 infection, and this grief reaction might have deleterious effects on their life. This cross-sectional observational online study aimed to investigate the…
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Sleep in post-COVID-19 recovery period and its impact on different domains of quality of life
BACKGROUND: COVID-19 pandemic became a global health problem affecting the life of millions of people all over the world. The effects of this pandemic were not only on the physical and medical aspects but also on the psychological issues including anxiety disorders, depressive manifestations, sleep…
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Metabolic profile in first episode drug naïve patients with psychosis and its relation to cognitive functions and social cognition: a case control study
1st episode drug naïve patients with psychosis might be at higher risk for cardiometabolic disturbances which could affect the different cognitive, and executive functions and domains of social cognition. This study aimed to study the metabolic parameters in 1st episode drug naïve patients with…
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AegisGuard: A Multi-Stage Hybrid Intrusion Detection System with Optimized Feature Selection for Industrial IoT Security
The rapid expansion of the Industrial Internet of Things (IIoT) within smart grid infrastructures has increased the risk of sophisticated cyberattacks, where severe class imbalance and stringent real-time requirements continue to hinder the effectiveness of conventional intrusion detection systems…
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Resurgence of the COVID-19 cases in Northern Afghanistan: Are we closer to fifth wave?
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Increased Glucagon-Like Peptide-1 Secretion and Postprandial Hypoglycemia in Children after Nissen Fundoplication
Context: Postprandial hypoglycemia (PPH) is a frequent complication of Nissen fundoplication in children. The mechanism responsible for the PPH is poorly understood, but involves an exaggerated insulin response to a meal and subsequent hypoglycemia. We hypothesize that increased glucagon-like…
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Punching Shear Behavior of HPRC Slab–Corner Column Joints
Flat slab systems are widely used in modern buildings due to their architectural flexibility and construction efficiency. However, their structural performance is often governed by punching shear failure at slab–column connections, particularly at corner joints where the effective shear perimeter…
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Assessing self-stigma levels and associated factors among substance use disorder patients at two selected psychiatric hospitals in Egypt: a cross-sectional study
BACKGROUND: Substance use disorder is a growing problem worldwide, and the stigma associated with it remains a significant barrier to treatment and recovery. This study aimed to assess the perceived stigma among individuals with substance use disorders and its correlation with their…
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COVID-19 Pandemic–Related Reductions in Pediatric Asthma Exacerbations Corresponded with an Overall Decrease in Respiratory Viral Infections
BACKGROUND: Respiratory viruses, air pollutants, and aeroallergens are all implicated in worsening pediatric asthma symptoms, but their relative contributions to asthma exacerbations are poorly understood. A significant decrease in asthma exacerbations has been observed during the coronavirus…
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Pediatric Asthma Health Care Utilization, Viral Testing, and Air Pollution Changes During the COVID-19 Pandemic
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic caused dramatic changes in daily routines and health care utilization and delivery patterns in the United States. Understanding the influence of these changes and associated public health interventions on asthma care is important to…
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Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations
OBJECTIVE: Heterozygous activating mutations of glucokinase have been reported to cause hypoglycemia attributable to hyperinsulinism in a limited number of families. We report three children with de novo glucokinase hyperinsulinism mutations who displayed a spectrum of clinical phenotypes…
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Comparison of Two ELISA Methods and Mass Spectrometry for Measurement of Vitamin D-Binding Protein: Implications for the Assessment of Bioavailable Vitamin D Concentrations across Genotypes
Studies using vitamin D-binding protein (DBP) concentrations to estimate free and bioavailable vitamin D have increased dramatically in recent years. Combinations of two single-nucleotide polymorphisms produce three major DBP isoforms (Gc1f, Gc1s and Gc2). A recent study showed that DBP…
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Mechanism of Hyperinsulinism in Short-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Involves Activation of Glutamate Dehydrogenase
The mechanism of insulin dysregulation in children with hyperinsulinism associated with inactivating mutations of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) was examined in mice with a knock-out of the hadh gene (hadh(−/−)). The hadh(−/−) mice had reduced levels of plasma glucose and…
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Aberrant STAT signaling drives T cell dysregulation in a targetable pediatric sepsis endotype
Sepsis is a leading cause of morbidity and mortality in critically ill children, yet heterogeneity in immune responses complicates the development of targeted therapies. Although immune dysregulation is associated with poor outcomes in sepsis, it remains unclear which host immune factors contribute…
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Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome
Signal transduction downstream of activating stimuli controls CD8+ T cell biology, however these external inputs can become uncoupled from transcriptional regulation in Primary Immune Regulatory Disorders (PIRDs). Gain-of-function (GOF) variants in STAT3 amplify cytokine signaling and cause a…
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Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19
Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death…
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The immunopathological landscape of human pre-TCRα deficiency: from rare to common variants
We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre-TCRα expression. Low circulating naïve αβ T cell counts at birth persisted over time, with normal memory αβ and high γδ T cell counts. Their TCRα repertoire was biased, suggesting that noncanonical thymic…