10 hasil untuk "Selvakumar Subbian"

Mathematical modeling suggests heterogeneous replication of Mycobacterium tuberculosis in rabbits

Vitaly V. Ganusov; Afsal Kolloli; Selvakumar Subbian

PLOS Computational Biology, Vol. 20 No. 11 · 2024 · Inggris · PLOS Scopus

Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), remains a major health problem with 10.6 million cases of the disease and 1.6 million deaths in 2021. It is well understood that pulmonary TB is due to Mtb growth in the lung but quantitative estimates of rates of Mtb…

Correction: Mathematical modeling suggests heterogeneous replication of Mycobacterium tuberculosis in rabbits

Vitaly V. Ganusov; Afsal Kolloli; Selvakumar Subbian

PLOS Computational Biology, Vol. 21 No. 4 · 2025 · Inggris · PLOS Scopus

Host Targeted Activity of Pyrazinamide in Mycobacterium tuberculosis Infection

Claudia Manca; Mi-Sun Koo; Blas Peixoto dkk.

PLoS ONE, Vol. 8 No. 8 · 2013 · Inggris · PLOS Scopus

Pyrazinamide (PZA) is one of the first line antibiotics used for the treatment of tuberculosis (TB). In the present study, we have used in vitro and in vivo systems to investigate whether PZA, in addition to its known anti-mycobacterial properties, modulate the host immune response during…

Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage

Valentina Guerrini; Selvakumar Subbian; Pierre Santucci dkk.

PLOS ONE, Vol. 11 No. 12 · 2016 · Inggris · PLOS Scopus

Isolates of the human pathogen Mycobacterium tuberculosis recovered from clinical samples exhibit genetic heterogeneity. Such variation may result from the stressful environment encountered by the pathogen inside the macrophage, which is the host cell tubercle bacilli parasitize. To study the…

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

Selvakumar Subbian; Liana Tsenova; Paul O'Brien dkk.

PLoS Pathogens, Vol. 7 No. 9 · 2011 · Inggris · PLOS Scopus

Tuberculosis (TB) treatment is hampered by the long duration of antibiotic therapy required to achieve cure. This indolent response has been partly attributed to the ability of subpopulations of less metabolically active Mycobacterium tuberculosis (Mtb) to withstand killing by current anti-TB…

Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

Mi-Sun Koo; Claudia Manca; Guibin Yang dkk.

PLoS ONE, Vol. 6 No. 2 · 2011 · Inggris · PLOS Scopus

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the leading infectious disease causes of morbidity and mortality worldwide. Though current antibiotic regimens can cure the disease, treatment requires at least six months of drug therapy. One reason for the long duration of…

Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study

Selvakumar Subbian; Liana Tsenova; Mi-Jeong Kim dkk.

PLOS ONE, Vol. 10 No. 7 · 2015 · Inggris · PLOS Scopus

The formation and maintenance of granulomas is central to the host response to Mycobacterium tuberculosis (Mtb) infection. It is widely accepted that the lungs of patients with tuberculosis (TB) usually contain multiple infection foci, and that the granulomas evolve and differentiate independently…

Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis

Poornima Sankar; Ramon Bossardi Ramos; Jamie Corro dkk.

PLOS Pathogens, Vol. 20 No. 10 · 2024 · Inggris · PLOS Scopus

Mycobacterium tuberculosis (Mtb) infection induces a marked influx of neutrophils into the lungs, which intensifies the severity of tuberculosis (TB). The metabolic state of neutrophils significantly influences their functional response during inflammation and interaction with bacterial pathogens…

Dynamics of temporal immune responses in nonhuman primates and humans immunized with COVID-19 vaccines

Resmi Ravindran; Harsharonjit Kang; Cindy McReynolds dkk.

PLOS ONE, Vol. 18 No. 10 · 2023 · Inggris · PLOS Scopus

We assessed the humoral immune responses to a COVID-19 vaccine in a well-controlled rhesus macaque model compared to humans immunized with two mRNA vaccines over several months post-second dose. The plasma IgG levels against seven coronaviruses (including SARS-CoV-2) and antibody subtypes (IgG 1–4…

Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific

Valentina Guerrini; Brendan Prideaux; Landry Blanc dkk.

PLOS Pathogens, Vol. 14 No. 8 · 2018 · Inggris · PLOS Scopus

Foam cells are lipid-laden macrophages that contribute to the inflammation and tissue damage associated with many chronic inflammatory disorders. Although foam cell biogenesis has been extensively studied in atherosclerosis, how these cells form during a chronic infectious disease such as…