11 hasil untuk "Servius"

Characterizing the excision of 7,8-dihydro-8-oxoadenine by thymine DNA glycosylase

Servius, Hardler W.; Drohat, Alexander C.

J Biol Chem · 2025 · Inggris · PubMed Central

Oxidation of DNA yields mutagenic and cytotoxic lesions that threaten genomic integrity, cause cancer and other diseases, and contribute to aging. Oxidative damage is countered by base excision repair, a pathway initiated by DNA glycosylases, which cleave bases through N-glycosyl bond hydrolysis…

In Vergilii carmina commentarii

Servius

North-Holland Pub. Co. · 1878 · Latin · Open Library

Servii in Verg. Aen. 139-200 Commenta

Servius

Gedruckt bei H. Sieling · 1856 · Open Library

Commentarii in Virgilium Serviani; sive, Commentarii in Virgilium qui Mauro Servio Honorato ...

Servius

Vandenhoeck Et Ruprecht · 1826 · Latin · Open Library

Rapid excision of oxidized adenine by human thymine DNA glycosylase

Servius, Hardler W.; Pidugu, Lakshmi S.; Sherman, Matthew E. dkk.

J Biol Chem · 2022 · Inggris · PubMed Central

Oxidation of DNA bases generates mutagenic and cytotoxic lesions that are implicated in cancer and other diseases. Oxidative base lesions, including 7,8-dihydro-8-oxoguanine, are typically removed through base excision repair. In addition, oxidized deoxynucleotides such as 8-oxo-dGTP are depleted…

Persii Trevi [pseud.] Ad librum de sero lactis Stephani Roderici Castrensis Lusitani declamationes

Petrus Servius

Ex typographia Francisci Corbelletti · 1634 · Latin · Open Library

Sumoylation of thymine DNA glycosylase impairs productive binding to substrate sites in DNA

Pidugu, Lakshmi S.; Servius, Hardler W.; Espinosa, Kurt B. dkk.

J Biol Chem · 2024 · Inggris · PubMed Central

The base excision repair enzyme thymine DNA glycosylase (TDG) protects against mutations by removing thymine or uracil from guanine mispairs and functions in active DNA demethylation by excising 5-formylcytosine (fC) and 5-carboxylcytosine (caC). Post-translational modification of TDG by SUMO…

Characterizing inhibitors of human AP endonuclease 1

Pidugu, Lakshmi S.; Servius, Hardler W.; Sevdalis, Spiridon E. dkk.

PLoS One · 2023 · Inggris · PubMed Central

AP endonuclease 1 (APE1) processes DNA lesions including apurinic/apyrimidinic sites and 3´-blocking groups, mediating base excision repair and single strand break repair. Much effort has focused on developing specific inhibitors of APE1, which could have important applications in basic research…

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Observing nucleotide flipping in DNA using indirect 2′-F nucleotide probes and (19)F NMR

Pidugu, Lakshmi S; Gustafson, Erin E; Servius, Hardler W dkk.

Nucleic Acids Res · 2025 · Inggris · PubMed Central

Many proteins that bind specifically to DNA and RNA employ a mechanism known as nucleotide flipping, whereby a nucleotide rotates out of the helical stack and into an active site. This conformational change can be monitored using spectroscopic methods, including fluorescence and nuclear magnetic…