98 hasil untuk "Shakeel, Muhammad"
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Functions of somatic cells for spermatogenesis in stallions
Spermatogenesis and testis development are highly structured physiological processes responsible for post-pubertal fertility in stallions. Spermatogenesis comprises spermatocytogenesis, meiosis, and spermiogenesis. Although germ cell degeneration is a continuous process, its effects are more…
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Heat stress and stallion fertility
The threat posed by increased surface temperatures worldwide has attracted the attention of researchers to the reaction of animals to heat stress. Spermatogenesis in animals such as stallions is a temperature-dependent process, ideally occurring at temperatures slightly below the core body…
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Brain-derived neurotrophic factor and neurotrophic tyrosine receptor kinase-2 in stallion testes: insights into seasonal changes and potential roles in spermatogenesis
Brain-derived neurotrophic factor (BDNF) and its receptor neurotrophic tyrosine receptor kinase-2 (NTRK2) have known important roles in the central nervous system for neurite growth, survival, and differentiation. Nevertheless, the significance of BDNF in spermatogenesis remains unclear in…
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Estimating the mutational load for cardiovascular diseases in Pakistani population
The deleterious genetic variants contributing to certain diseases may differ in terms of number and allele frequency from population to population depending on their evolutionary background. Here, we prioritize the deleterious variants from Pakistani population in manually curated gene list already…
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MicroRNA-Mediated Host-Pathogen Interactions Between Bombyx mori and Viruses
MicroRNAs (miRNAs), small non-coding RNAs of about 22 nucleotides, have been reported to regulate gene expression at the posttranscriptional level and are involved in several biological processes such as immunity, development, metabolism, and host-pathogen interactions. Apart from miRNAs encoded by…
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Mislaid dentures: a cause for unusual presentation of bilateral vocal cord palsy
An 81-year-old man was referred urgently to the head and neck clinic with symptoms of worsening dysphagia, dysphonia and weight loss. He had a history of chronic lymphocytic leukaemia. On full ear, nose and throat examination, he was found to have fixed vocal cords with pooling of saliva in the…
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An Opposite Pattern to the Conventional Thermal Hypothesis: Temperature-Dependent Variation in Coloration of Adults of Saccharosydne procerus (Homoptera: Delphacidae)
Melanism is a common polymorphism in many insect species that also influences immune function. According to the thermal melanin hypothesis, ectothermic individuals from cooler environments have darker cuticles and higher polyphenol oxidase (PO) levels, which represent a better immunocompetence. In…
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Tracheo-oesophageal groove Hodgkin’s lymphoma presenting as stridor: a diagnostic challenge
A 38-year-old male patient presented to the ear, nose and throat department with shortness of breath over last 2 months. The CT scan of the neck and chest revealed a 3.3×3 cm tumour behind the right thyroid lobe extending into the tracheo-oesophageal (TO) groove with tracheal compression. The…
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Simultaneous double laryngeal tumours: a diagnostic and therapeutic challenge
Leiomyosarcomas are soft tissue tumours that rarely occur in the larynx. This case report describes the presentation and management of a 77-year-old man referred to the otolaryngology clinic with hoarseness who was found to have a large supraglottic leiomyosarcoma after panendoscopy and biopsies…
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Optical soliton solutions, dynamical and sensitivity analysis for fractional perturbed Gerdjikov–Ivanov equation
This work constructs the distinct type of solitons solutions to the nonlinear Perturbed Gerdjikov-Ivanov (PGI) equation with Atangana’s derivative. It interprets its optical soliton solutions in the existence of high-order dispersion. For this purpose, a wave transformation is applied to convert…
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Complex travelling wave solutions of fractional nonlinear coupled malaria model: bifurcation, chaos, and multistability
This study explore the dynamics of malaria transmission utilizing a novel fractional nonlinear coupled malaria model with a beta derivative, intending to expand our understanding of the complex factors that drive disease spread. By using the General Exponential Rational Function Method (GERFM), the…
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The effect of female participation in top management teams on the growth performance of small and medium-sized enterprises (SMEs): Evidence from a panel-data analysis in Chinese-listed SMEs
Purpose - This paper aims to examine the relationship between the female participation in top management team (TMT) and the growth performance of small and medium-sized enterprises (SMEs) in the Chinese economic environment. Design/methodology/approach - Adopting resource dependence theory, this…
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Cubic Ordered Weighted Distance Operator and Application in Group Decision-Making
Group decision-making is a very useful technique for ranking the group of alternatives. The ordered weighted distance (OWD) operator is a new tool in group decision-making problems. In this paper, we apply the OWD operator on cubic information. We develop a new operator, the so-called cubic OWD…
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Unlocking Citizen Developer Potential: A Systematic Review and Model for Digital Transformation
Citizen developers, individuals outside formal IT departments who create applications using low-code/no-code platforms, are becoming increasingly pivotal as organizations navigate digital transformation. The driving force behind this paradigm shift stems from an exponentially growing demand for…
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Empowering women entrepreneurs: Harnessing social networks and resource gap with the role of institutional support to achieve sustainable development goals in Pakistan
Women entrepreneurship in Pakistan is vital for economic growth yet remains less profitable than men's businesses, challenging goals for gender equality (SDG 5) and decent work (SDG 8). Grounded on resource-based theory (RBT), this study investigates how social networking, resource shortage, and…
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Investigation of molecular heterogeneity of β-thalassemia disorder in District Charsadda of Pakistan
OBJECTIVE: Thalassemia is blood related disease which arises from the reduced level of hemoglobin in red blood cells (RBC), a protein responsible for carrying oxygen inside the body. Considering its widespread occurrence in developing countries like Pakistan, this study aims to investigate the…
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Primary thyroid leiomyosarcoma: a diagnostic and therapeutic challenge
Leiomyosarcoma is a malignant mesenchymal tumour of smooth muscle origin. It is extremely rare as a primary thyroid cancer with only 33 cases previously described in the literature. We present the case of a 69-year-old Caucasian man who presented with a 5-month history of left cervical…
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Sclerosing variant of mucoepidermoid carcinoma: a diagnostic challenge
The sclerosing variant of mucoepidermoid salivary gland carcinoma is extremely rare. It is nearly impossible to diagnose this condition preoperatively. We present a case of a 23-year-old woman with a 1-year history of left parotid enlargement with inconclusive fine-needle aspiration cytology…
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Primary thyroid squamous cell carcinoma: a challenging management problem
Primary thyroid squamous cell carcinoma (SCC) is a rare and highly aggressive cancer. Diagnostic work-up encompasses cervical ultrasonography, tissue biopsy and CT scan. Surgery, radiotherapy and chemotherapy are the available treatment modalities. With a mean survival rate of 7 months reported in…
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Exploring complex dynamics in nonlinear Riemann wave models using fractional calculus-based expansion
The nonlinear coupled Riemann wave equation serves as a mathematical framework for analyzing the interaction between short and long waves in various physical phenomena. Its importance lies in capturing both soliton-like behaviors and complex instabilities that arise in nonlinear media. Despite this…