2 results for "Simone Conti"
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Journal Article Full text
Estimation of the breadth of CD4bs targeting HIV antibodies by molecular modeling and machine learning
HIV is a highly mutable virus for which all attempts to develop a vaccine have been unsuccessful. Nevertheless, few long-infected patients develop antibodies, called broadly neutralizing antibodies (bnAbs), that have a high breadth and can neutralize multiple variants of the virus. This suggests…
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Journal Article Full text
Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV
The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of B cell receptor (BCR) affinity maturation that…