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GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors

Atsuko Fukazawa; Carmen Alonso; Kiyotaka Kurachi dkk.

PLoS Pathogens, Vol. 4 No. 11 · 2008 · Inggris · PLOS Scopus

Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine…