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Universal DNA methylation age across mammalian tissues

Ake Tzu-Hui Lu; Zhe Fei; Amin Haghani dkk.

Nature Aging · 2023 · Inggris · OpenAlex Scopus

Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian…