1 results for "Su-Lin Lim"

Multiple myeloma: Combination therapy of BET proteolysis targeting chimeric molecule with CDK9 inhibitor

Su-Lin Lim; Liang Xu; Bing-Chen Han et al.

PLOS ONE, Vol. 15 No. 6 · 2020 · English · PLOS Scopus

Cyclin Dependent Kinase 9 (CDK9) associates with Bromodomain and Extra-Terminal Domain (BET) proteins to promote transcriptional elongation by phosphorylation of serine 2 of RNAP II C-terminal domain. We examined the therapeutic potential of selective CDK9 inhibitors (AZD 4573 and MC180295) against…