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3 results for "Tianshuang Liu"

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  1. Journal Article Full text

    Human Metapneumovirus Glycoprotein G Disrupts Mitochondrial Signaling in Airway Epithelial Cells

    Xiaoyong Bao; Deepthi Kolli; Junping Ren et al.

    PLoS ONE, Vol. 8 No. 4 · 2013 · English · PLOS Scopus

    Human metapneumovirus (hMPV) is a recently identified RNA virus belonging to the Paramyxoviridae family. It is a common cause of respiratory tract infections in children, adults, and immunocompromised patients, for which no specific treatment or vaccine is available. Recent investigations in our…

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  2. Journal Article Full text

    Human Metapneumovirus Glycoprotein G Inhibits Innate Immune Responses

    Xiaoyong Bao; Tianshuang Liu; Yichu Shan et al.

    PLoS Pathogens, Vol. 4 No. 5 · 2008 · English · PLOS Scopus

    Human metapneumovirus (hMPV) is a leading cause of acute respiratory tract infection in infants, as well as in the elderly and immunocompromised patients. No effective treatment or vaccine for hMPV is currently available. A recombinant hMPV lacking the G protein (rhMPV-ΔG) was recently developed as…

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  3. Journal Article Full text

    Human Metapneumovirus Inhibits IFN-β Signaling by Downregulating Jak1 and Tyk2 Cellular Levels

    Junping Ren; Deepthi Kolli; Tianshuang Liu et al.

    PLoS ONE, Vol. 6 No. 9 · 2011 · English · PLOS Scopus

    Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, inhibits type I interferon (IFN) signaling by an unidentified mechanism. In this study, we showed that infection of airway epithelial cells with hMPV decreased cellular level of Janus tyrosine kinase (Jak1)…

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