16 results for "Torsten Witte"

Association of the LILRA3 Deletion with B-NHL and Functional Characterization of the Immunostimulatory Molecule

Hui Zhi Low; Sandra Reuter; Michael Topperwien et al.

PLoS ONE, Vol. 8 No. 12 · 2013 · English · PLOS Scopus

LILRA3 is the sole soluble member of the LILR family. Previous studies from our group had shown that a 6.7 kb genetic deletion of LILRA3 is associated with MS and Sjögren’s syndrome. An impairment of the immune response leads to a predisposition for B-NHL, so we wanted to study whether the deletion…

Association of CD247 Polymorphisms with Rheumatoid Arthritis: A Replication Study and a Meta-Analysis

María Teruel; Cushla McKinney; Alejandro Balsa et al.

PLoS ONE, Vol. 8 No. 7 · 2013 · English · PLOS Scopus

Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537)…

Evidence of New Risk Genetic Factor to Systemic Lupus Erythematosus: The UBASH3A Gene

Lina-Marcela Diaz-Gallo; Elena Sánchez; Norberto Ortego-Centeno et al.

PLoS ONE, Vol. 8 No. 4 · 2013 · English · PLOS Scopus

The ubiquitin associated and Src-homology 3 (SH3) domain containing A (UBASH3a) is a suppressor of T-cell receptor signaling, underscoring antigen presentation to T-cells as a critical shared mechanism of diseases pathogenesis. The aim of the present study was to determine whether the UBASH3a gene…

Increased HEV Seroprevalence in Patients with Autoimmune Hepatitis

Sven Pischke; Anett Gisa; Pothakamuri Venkata Suneetha et al.

PLoS ONE, Vol. 9 No. 1 · 2014 · English · PLOS Scopus

Background: Hepatitis E virus (HEV) infection takes a clinically silent, self-limited course in the far majority of cases. Chronic hepatitis E has been reported in some cohorts of immunocompromised individuals. The role of HEV infections in patients with autoimmune hepatitis (AIH) is unknown…

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

Sebastian J. Theobald; Christoph Kreer; Sahamoddin Khailaie et al.

PLOS Pathogens, Vol. 16 No. 7 · 2020 · English · PLOS Scopus

Human cytomegalovirus (HCMV) causes serious complications to immune compromised hosts. Dendritic cells (iDCgB) expressing granulocyte-macrophage colony-stimulating factor, interferon-alpha and HCMV-gB were developed to promote de novo antiviral adaptive responses. Mice reconstituted with a human…

Correction: Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

Sebastian J. Theobald; Christoph Kreer; Sahamoddin Khailaie et al.

PLOS Pathogens, Vol. 17 No. 3 · 2021 · English · PLOS Scopus

A Candidate Gene Approach Identifies an IL33 Genetic Variant as a Novel Genetic Risk Factor for GCA

Ana Márquez; Roser Solans; José Hernández-Rodríguez et al.

PLoS ONE, Vol. 9 No. 11 · 2014 · English · PLOS Scopus

Introduction: Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci on…

Identification of the Tyrosine-Protein Phosphatase Non-Receptor Type 2 as a Rheumatoid Arthritis Susceptibility Locus in Europeans

Joanna E. Cobb; Darren Plant; Edward Flynn et al.

PLoS ONE, Vol. 8 No. 6 · 2013 · English · PLOS Scopus

Objectives: Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA. Methods: A…

Further Evidence of Subphenotype Association with Systemic Lupus Erythematosus Susceptibility Loci: A European Cases Only Study

Elisa Alonso-Perez; Marian Suarez-Gestal; Manuel Calaza et al.

Public Library of Science · 2012 · English · PLOS Scopus

Introduction: Systemic Lupus Erythematosus (SLE) shows a spectrum of clinical manifestations that complicate its diagnosis, treatment and research. This variability is likely related with environmental exposures and genetic factors among which known SLE susceptibility loci are prime candidates. The…

Association of Systemic Lupus Erythematosus Clinical Features with European Population Genetic Substructure

Elisa Alonso-Perez; Marian Suarez-Gestal; Manuel Calaza et al.

PLoS ONE, Vol. 6 No. 12 · 2011 · English · PLOS Scopus

Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a very varied spectrum of clinical manifestations that could be partly determined by genetic factors. We aimed to determine the relationship between prevalence of 11 clinical features and age of disease onset with European population…

A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility

David González-Serna; Elio G. Carmona; Norberto Ortego-Centeno et al.

PLOS ONE, Vol. 13 No. 12 · 2018 · English · PLOS Scopus

Background: The TNFSF13B (TNF superfamily member 13b) gene encodes BAFF, a cytokine with a crucial role in the differentiation and activation of B cells. An insertion-deletion variant (GCTGT→A) of this gene, leading to increased levels of BAFF, has been recently implicated in the genetic…

The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis

F. David Carmona; Jose-Ezequiel Martin; Lorenzo Beretta et al.

PLoS ONE, Vol. 8 No. 1 · 2013 · English · PLOS Scopus

Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory factor 5 (IRF5), a major regulator of the type I…

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

He Li; Tove Ragna Reksten; John A. Ice et al.

PLOS Genetics, Vol. 13 No. 6 · 2017 · English · PLOS Scopus

Sjögren’s syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debilitating fatigue. Dysregulation of type I interferon…

Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

Olga Gorlova; Jose-Ezequiel Martin; Blanca Rueda et al.

PLoS Genetics, Vol. 7 No. 7 · 2011 · English · PLOS Scopus

The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (lcSSc) and diffuse (dcSSc) cutaneous involvement, and the relationships with presence…

Correction: Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

Olga Gorlova; Jose-Ezequiel Martin; Blanca Rueda et al.

PLoS Genetics, Vol. 7 No. 8 · 2011 · English · PLOS Scopus

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