125 hasil untuk "Tyler, Kenneth L"
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Artikel Jurnal Teks lengkap
Current developments in understanding of West Nile virus central nervous system disease
PURPOSE OF REVIEW: West Nile virus (WNV) is the most important cause of epidemic encephalitis in the United States. We review articles published in the last 18 months related to the epidemiology, immunology, clinical features, and treatment of this disease. RECENT FINDINGS: There was a resurgence…
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Emerging Viral Infections of the Central Nervous System
In this 2-part review, I will focus on emerging virus infections of the central nervous system (CNS). Part 1 will introduce the basic features of emerging infections, including their definition, epidemiology, and the frequency of CNS involvement. Important mechanisms of emergence will be reviewed…
Juga tersedia di: PubMed Central
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Rationale for the Evaluation of Fluoxetine in the Treatment of Enterovirus D68-Associated Acute Flaccid Myelitis
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Host and viral factors that influence viral neurotropism I. Viral cell attachment proteins and target cell receptors
Since the time of Charcot, over a century ago, it has been recognized that the clinical signs and symptoms produced by viral illnesses involving the CNS are due in large part to the specific regions of the nervous system injured. As the list of viruses capable of infecting the CNS expanded rapidly…
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Host and viral genetic factors which influence viral neurotropism
This chapter reviews host and viral genetic factors that influence viral neurotropism. It highlights a few recent insights that have been gained into the molecular and genetic basis for viral tropism, with specific emphasis on the factors that appear particularly relevant to understanding the basis…
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Host and viral factors that influence viral neurotropism II. Viral genes, host genes, site of entry and route of spread of virus
In the previous article in this series, we focused on how the interaction between viral cell attachment proteins and receptor molecules on the surface of host target cells played a major role in determining the cell and tissue tropism of many neurotropic viruses. In order to complete our review of…
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The enigmatic links between Epstein-Barr virus infection and multiple sclerosis
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Artikel Jurnal Teks lengkap
Novel approaches and challenges to treatment of central nervous system viral infections
Existing and emerging viral central nervous system (CNS) infections are major sources of human morbidity and mortality. Treatments of proven efficacy are currently limited predominantly to herpesviruses and human immunodeficiency virus (HIV). Development of new therapies has been hampered by the…
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Apoptosis in animal models of virus-induced disease
Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes substantial morbidity and mortality. Although virus-induced apoptosis is well characterized in individual cells in cell culture, virus-induced apoptosis in vivo and the role of…
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Emerging Diagnostic and Therapeutic Tools for Central Nervous System Infections
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Artikel Jurnal Teks lengkap
West Nile virus meningoencephalitis
Since its first appearance in the US in 1999, West Nile virus (WNV) has emerged as the most common cause of epidemic meningoencephalitis in North America. In the 6 years following the 1999 outbreak, the geographic range and burden of the disease in birds, mosquitoes and humans has greatly expanded…
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Artikel Jurnal Teks lengkap
Neuro-Intensive Care of Patients with Acute CNS Infections
Infections in the central nervous system (CNS) are caused by a wide range of microorganisms resulting in distinct clinical syndromes including meningitis, encephalitis, and pyogenic infections, such as empyema and brain abscess. Bacterial and viral infections in the CNS can be rapidly fatal and can…
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Artikel Jurnal Teks lengkap
Molecular Methods for Diagnosis of Viral Encephalitis
Hundreds of viruses cause central nervous system (CNS) disease, including meningoencephalitis and postinfectious encephalomyelitis, in humans. The cerebrospinal fluid (CSF) is abnormal in >90% of cases; however, routine CSF studies only rarely lead to identification of a specific etiologic agent…