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Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent Cl− Transport in Retinal Amacrine Cells

Tyler Christopher Rodriguez; Li Zhong; Hailey Simpson dkk.

Frontiers in Cellular Neuroscience, Vol. 16 · 2022 · Inggris · DOAJ Scopus

Postsynaptic cytosolic Cl− concentration determines whether GABAergic and glycinergic synapses are inhibitory or excitatory. We have shown that nitric oxide (NO) initiates the release of Cl− from acidic internal stores into the cytosol of retinal amacrine cells (ACs) thereby elevating cytosolic…