7 hasil untuk "Weekley, Benjamin"
Menampilkan 1–7 · 0,42 detik · RSS
-
Artikel Jurnal Teks lengkap
The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes
BACKGROUND: Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukaryotes, generating a cleaved H3 product that is retained in ~ 5–10% of the genome. Although H3NT proteolysis within chromatin was first reported over 60 years ago…
-
Artikel Jurnal Teks lengkap
Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders
The evolving field of neuroepigenetics provides important insights into the molecular foundations of brain function. Novel sequencing technologies have identified patient-specific mutations and gene expression profiles involved in shaping the epigenetic landscape during neurodevelopment and in…
-
Artikel Jurnal Teks lengkap
A Novel Aminoacyl-tRNA Synthetase Appended Domain Can Supply the Core Synthetase with Its Amino Acid Substrate
The structural organization and functionality of aminoacyl-tRNA synthetases have been expanded through polypeptide additions to their core aminoacylation domain. We have identified a novel domain appended to the methionyl-tRNA synthetase (MetRS) of the intracellular pathogen Mycoplasma penetrans…
-
Artikel Jurnal Teks lengkap
MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation
BACKGROUND: Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of the genome. Although increasing evidence supports a regulatory role for H3NT…
-
Artikel Jurnal Teks lengkap
Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum
Pregnancy and postpartum experiences represent transformative physiological states that impose lasting demands on the maternal body and brain, resulting in lifelong neural adaptations(1–6). However, the precise molecular mechanisms driving these persistent alterations remain poorly understood…
-
Artikel Jurnal Teks lengkap
Quinone reductase 2 reads H3 serotonylation to support neuronal maturation
Histone H3 Gln5 serotonylation (H3Q5ser) is a recently described posttranslational modification (1) that plays important roles in guiding transcriptional permissiveness in brain and peripheral systems (2–5) . H3Q5ser has been implicated in diverse physiological and pathological processes ranging…
-
Artikel Jurnal Teks lengkap
Bidirectional histone monoaminylation dynamics regulate neural rhythmicity
Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression(1–3). We previously demonstrated that serotonylation(4–10) and dopaminylation(9,11–13) of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are…