35 hasil untuk "Yang Lin"

Significance of DNMT3b in Oral Cancer

Wen-Cheng Chen; Miao-Fen Chen; Paul-Yang Lin

PLoS ONE, Vol. 9 No. 3 · 2014 · Inggris · PLOS Scopus

The aim of this study was to explore specific molecular markers that could lead to new insights into the identification of innovative treatments. The role of DNMT3b and its predictive power in the prognosis of oral cancer were identified. Human oral cancer cell lines including SCC4 and SCC25 were…

Towards low cost, multiplex clinical genotyping: 4-fluorescent Kompetitive Allele-Specific PCR and its application on pharmacogenetics

Wei Suo; Xiujin Shi; Sha Xu dkk.

PLOS ONE, Vol. 15 No. 3 · 2020 · Inggris · PLOS Scopus

Single-nucleotide polymorphisms (SNPs) is associated with efficacy of specific drugs. Although there are several methods for SNP genotyping in clinical settings, alternative methods with lower cost, higher throughout and less complexity are still needed. In this study, we modified Kompetitive…

Transcriptomics and metabolomics reveal the mechanism of metabolites changes in Cymbidium tortisepalum var. longibracteatum colour mutation cultivars

Yu Jiang; Yaqin Liu; Yang Lin dkk.

PLOS ONE, Vol. 19 No. 6 · 2024 · Inggris · PLOS Scopus

Background: Foliage color is considered an important ornamental character of Cymbidium tortisepalum (C. tortisepalum), which significantly improves its horticultural and economic value. However, little is understood on the formation mechanism underlying foliage-color variations. Methods: In this…

Exploring the accuracy of the Xpert MTB/RIF assay in detecting lymph node tuberculosis: A systematic review and meta-analysis

Zi-Ke Chen; Zhao Wu; Ting Ye dkk.

PLOS One, Vol. 20 No. 5 · 2025 · Inggris · PLOS Scopus

Background: The Xpert MTB/RIF assay has exhibited high diagnostic efficiency in detecting lymph node tuberculosis (LNTB). However, different gold standards and types of LNTB specimens may impact Xpert’s diagnostic accuracy. This meta-analysis compared the performance of Xpert MTB/RIF on fine needle…

Hippocampal Desynchronization of Functional Connectivity Prior to the Onset of Status Epilepticus in Pilocarpine-Treated Rats

Chi-Han Wang; Chou P. Hung; Ming-Teh Chen dkk.

PLoS ONE, Vol. 7 No. 6 · 2012 · Inggris · PLOS Scopus

Status epilepticus (SE), a pro-epileptogenic brain insult in rodent models of temporal lobe epilepsy, is successfully induced by pilocarpine in some, but not all, rats. This study aimed to identify characteristic alterations within the hippocampal neural network prior to the onset of SE. Sixteen…

Altered Oscillation and Synchronization of Default-Mode Network Activity in Mild Alzheimer’s Disease Compared to Mild Cognitive Impairment: An Electrophysiological Study

Fu-Jung Hsiao; Yuh-Jen Wang; Sui-Hing Yan dkk.

PLoS ONE, Vol. 8 No. 7 · 2013 · Inggris · PLOS Scopus

Some researchers have suggested that the default mode network (DMN) plays an important role in the pathological mechanisms of Alzheimer’s disease (AD). To examine whether the cortical activities in DMN regions show significant difference between mild AD from mild cognitive impairment (MCI)…

IL-6 Expression Regulates Tumorigenicity and Correlates with Prognosis in Bladder Cancer

Miao-Fen Chen; Paul-Yang Lin; Ching-Fang Wu dkk.

PLoS ONE, Vol. 8 No. 4 · 2013 · Inggris · PLOS Scopus

Identification of potential tumor markers will help stratify and identify a tumor's malignant potential and its response to specific therapies. IL-6 has been reported to be a predictor in various cancers. Therefore, the present study was performed to highlight the role of IL-6 in improving…

cis -Regulatory Complexity within a Large Non-Coding Region in the Drosophila Genome

Mukta Kundu; Alexander Kuzin; Tzu-Yang Lin dkk.

PLoS ONE, Vol. 8 No. 4 · 2013 · Inggris · PLOS Scopus

Analysis of cis-regulatory enhancers has revealed that they consist of clustered blocks of highly conserved sequences. Although most characterized enhancers reside near their target genes, a growing number of studies have shown that enhancers located over 50 kb from their minimal promoter(s) are…

Reduced Motor Cortex Deactivation in Individuals Who Suffer from Writer's Cramp

Yi-Jhan Tseng; Rou-Shayn Chen; Wan-Yu Hsu dkk.

PLoS ONE, Vol. 9 No. 5 · 2014 · Inggris · PLOS Scopus

This study investigated the neuromagnetic activities of self-paced finger lifting task and electrical median nerve stimulation in ten writer's cramp patients and fourteen control subjects. The event-related de/synchronizations (ERD/ERS) of beta-band activity levels were evaluated and the…

PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix

Ruth E. Thomas; Laurie A. Andrews; Jonathon L. Burman dkk.

PLoS Genetics, Vol. 10 No. 5 · 2014 · Inggris · PLOS Scopus

Loss-of-function mutations in PINK1, which encodes a mitochondrially targeted serine/threonine kinase, result in an early-onset heritable form of Parkinson's disease. Previous work has shown that PINK1 is constitutively degraded in healthy cells, but selectively accumulates on the surface of…

Correction: IL-6 Expression Regulates Tumorigenicity and Correlates with Prognosis in Bladder Cancer

Miao-Fen Chen; Paul-Yang Lin; Ching-Fang Wu dkk.

PLOS ONE, Vol. 11 No. 5 · 2016 · Inggris · PLOS Scopus

Clinical-CT mismatch defined NIHSS ≥ 8 and CT-ASPECTS ≥ 9 as a reliable marker of candidacy for intravenous thrombolytic therapy in acute ischemic stroke

Hung-Ming Wu; I-Hui Lee; Chao-Bao Luo dkk.

PLOS ONE, Vol. 16 No. 4 · 2021 · Inggris · PLOS Scopus

Background: Clinical-diffusion mismatch between stroke severity and diffusion-weighted imaging lesion volume seems to identify stroke patients with penumbra. However, urgent magnetic resonance imaging is sometimes inaccessible or contraindicated. Thus, we hypothesized that using brain computed…

A Putative Transcription Factor MYT2 Regulates Perithecium Size in the Ascomycete Gibberella zeae

Yang Lin; Hokyoung Son; Kyunghun Min dkk.

PLoS ONE, Vol. 7 No. 5 · 2012 · Inggris · PLOS Scopus

The homothallic ascomycete fungus Gibberella zeae is a plant pathogen that is found worldwide, causing Fusarium head blight (FHB) in cereal crops and ear rot of maize. Ascospores formed in fruiting bodies (i.e., perithecia) are hypothesized to be the primary inocula for FHB disease. Perithecium…

A Putative Transcription Factor MYT1 Is Required for Female Fertility in the Ascomycete Gibberella zeae

Yang Lin; Hokyoung Son; Jungkwan Lee dkk.

PLoS ONE, Vol. 6 No. 10 · 2011 · Inggris · PLOS Scopus

Gibberella zeae is an important pathogen of major cereal crops. The fungus produces ascospores that forcibly discharge from mature fruiting bodies, which serve as the primary inocula for disease epidemics. In this study, we characterized an insertional mutant Z39P105 with a defect in sexual…

Nine viruses from eight lineages exhibiting new evolutionary modes that co-infect a hypovirulent phytopathogenic fungus

Fan Mu; Bo Li; Shufen Cheng dkk.

PLOS Pathogens, Vol. 17 No. 8 · 2021 · Inggris · PLOS Scopus

Mycoviruses are an important component of the virosphere, but our current knowledge of their genome organization diversity and evolution remains rudimentary. In this study, the mycovirus composition in a hypovirulent strain of Sclerotinia sclerotiorum was molecularly characterized. Nine mycoviruses…

β5 Integrin Up-Regulation in Brain-Derived Neurotrophic Factor Promotes Cell Motility in Human Chondrosarcoma

Chih-Yang Lin; Hui-Jye Chen; Te-Mao Li dkk.

PLoS ONE, Vol. 8 No. 7 · 2013 · Inggris · PLOS Scopus

Chondrosarcoma is a primary malignant bone cancer, with a potent capacity to invade locally and cause distant metastasis; it has a poor prognosis and shows a predilection for metastasis to the lungs. Brain derived neurotrophic factor (BDNF) is a small-molecule protein from the neurotrophin family…

cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin

Der-Chih Yang; Huey-Jen Tsay; Shan-Yang Lin dkk.

PLoS ONE, Vol. 3 No. 2 · 2008 · Inggris · PLOS Scopus

Background: Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into adipocytes, osteoblasts and other cells. The reciprocal relationship between adipogenesis and osteogenesis was previously demonstrated; however, the mechanisms remain largely unknown. Methods and…

Gender Disparities in Latent Tuberculosis Infection in High-Risk Individuals: A Cross-Sectional Study

Wen-Ying Ting; Shiang-Fen Huang; Ming-Che Lee dkk.

PLoS ONE, Vol. 9 No. 11 · 2014 · Inggris · PLOS Scopus

Male predominance in active tuberculosis (TB) is widely-reported globally. Gender inequalities in socio-cultural status are frequently regarded as contributing factors for disparities in sex in active TB. The disparities of sex in the prevalence of latent TB infection (LTBI) are less frequently…

BMP-7 Enhances Cell Migration and αvβ3 Integrin Expression via a c-Src-Dependent Pathway in Human Chondrosarcoma Cells

Jui-Chieh Chen; Shu-Ting Yang; Chih-Yang Lin dkk.

PLoS ONE, Vol. 9 No. 11 · 2014 · Inggris · PLOS Scopus

Bone morphogenic protein (BMP)-7 is a member of the transforming growth factor (TGF)-beta superfamily, which is originally identified based on its ability to induce cartilage and bone formation. In recent years, BMP-7 is also defined as a potent promoter of cell motility, invasion, and metastasis…

Hyaluronic acid on the urokinase sustained release with a hydrogel system composed of poloxamer 407: HA/P407 hydrogel system for drug delivery

Hao-Ying Hsieh; Wei-Yang Lin; An Li Lee dkk.

PLOS ONE, Vol. 15 No. 3 · 2020 · Inggris · PLOS Scopus

Pleural empyema is an inflammatory condition characterized by accumulation of pus inside the pleural cavity, which is usually followed by bacterial pneumonia. During the disease process, the pro-inflammatory and pro-fibrotic cytokines in the purulent pleural effusion cause proliferation of…