1 hasil untuk "Young-Rae Lee"

Myeloid Deletion of SIRT1 Aggravates Serum Transfer Arthritis in Mice via Nuclear Factor-κB Activation

Young-Sool Hah; Yun-Hong Cheon; Hye Song Lim dkk.

PLoS ONE, Vol. 9 No. 2 · 2014 · Inggris · PLOS Scopus

Objective: SIRT1 modulates the acetylation of the p65 subunit of nuclear factor-κB (NF-κB) and plays a pivotal role in the inflammatory response. This study sought to assess the role of SIRT1 in rheumatoid arthritis (RA) using a myeloid cell-specific SIRT1 knockout (mSIRT1 KO) mouse. Methods…