240 results for "Yu Lin"
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Association Testing of Clustered Rare Causal Variants in Case-Control Studies
Biological evidence suggests that multiple causal variants in a gene may cluster physically. Variants within the same protein functional domain or gene regulatory element would locate in close proximity on the DNA sequence. However, spatial information of variants is usually not used in current…
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Adaptive Combination of P -Values for Family-Based Association Testing with Sequence Data
Family-based study design will play a key role in identifying rare causal variants, because rare causal variants can be enriched in families with multiple affected subjects. Furthermore, different from population-based studies, family studies are robust to bias induced by population substructure…
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A secure heterogeneous mobile authentication and key agreement scheme for e-healthcare cloud systems
Heterogeneous mobile authentication is a crucial technique to securely retrieve the resource of e-healthcare cloud servers which are commonly implemented in a public key Infrastructure (PKI). Conventionally, a mobile data user can utilize a self-chosen password along with a portable device to…
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Robust meta gradient learning for high-dimensional data with noisy-label ignorance
Large datasets with noisy labels and high dimensions have become increasingly prevalent in industry. These datasets often contain errors or inconsistencies in the assigned labels and introduce a vast number of predictive variables. Such issues frequently arise in real-world scenarios due to…
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Computational modeling for enhanced reliability in space missions: An integrated FAHP-COPRAS approach to supplier selection
Liquid Crystal Displays (LCDs) are indispensable in space science, playing critical roles in spacecraft instrumentation, data visualization, and control systems. Selecting reliable suppliers for LCD equipment is vital to ensuring optimal performance and durability in the challenging conditions of…
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Presenting the Uncertainties of Odds Ratios Using Empirical-Bayes Prediction Intervals
Quantifying exposure-disease associations is a central issue in epidemiology. Researchers of a study often present an odds ratio (or a logarithm of odds ratio, logOR) estimate together with its confidence interval (CI), for each exposure they examined. Here the authors advocate using the…
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Improving Power of Genome-Wide Association Studies with Weighted False Discovery Rate Control and Prioritized Subset Analysis
The issue of large-scale testing has caught much attention with the advent of high-throughput technologies. In genomic studies, researchers are often confronted with a large number of tests. To make simultaneous inference for the many tests, the false discovery rate (FDR) control provides a…
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The Human Frontal Oculomotor Cortical Areas Contribute Asymmetrically to Motor Planning in a Gap Saccade Task
Background: Saccadic eye movements are used to rapidly align the fovea with the image of objects of interest in peripheral vision. We have recently shown that in children there is a high preponderance of quick latency but poorly planned saccades that consistently fall short of the target goal. The…
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EPIC: Inferring relevant cell types for complex traits by integrating genome-wide association studies and single-cell RNA sequencing
More than a decade of genome-wide association studies (GWASs) have identified genetic risk variants that are significantly associated with complex traits. Emerging evidence suggests that the function of trait-associated variants likely acts in a tissue- or cell-type-specific fashion. Yet, it…
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The effect of CEO’s compensation in driving corporate ESG greenwashing: Evidence from China
This study examines the relationship between CEO compensation schemes and ESG greenwashing behavior in Chinese listed firms during the period 2013–2022. We find that a CEO’s cash (equity) compensation has a significantly positive (negative) correlation with corporate ESG greenwashing behavior. From…
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Simulating the Oceanic Migration of Silver Japanese Eels
The oceanic migration of silver Japanese eels starts from their continental growth habitats in East Asia and ends at the spawning area near the West Mariana Ridge seamount chain. However, the actual migration routes remain unknown. In this study, we examined the possible oceanic migration routes…
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The dynamical impact of mesoscale eddies on migration of Japanese eel larvae
In this study, we explore the dynamical role of mesoscale eddies on fish larvae migration using the example of Subtropical Counter Current eddies and the migration of Japanese eel larvae in the western North Pacific Ocean. An idealized experiment is conducted to isolate the effects of eddies, and…
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An evaluation of coupling coordination between sports industry and health service industry in China
Depending on the strategy of "Healthy China", more and more people pay attention to health issues. The integration and development of sports industry and health service industry is an inevitable outcome of industrial transformation and upgrading and healthy life in the new era. Through constructing…
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Beyond lethal temperatures: Factors behind the disappearance of chum salmon from their southern margins under climate change
The Tone River in Japan represents one of the southern limit distributions of chum salmon (Oncorhynchus keta) on the western side of the North Pacific, but the number of adult chum salmon observed here has declined dramatically since 2013 and reached zero in 2024. The factors behind the recent…
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Indoor Air Pollution, Nighttime Heart Rate Variability and Coffee Consumption among Convenient Store Workers
Background: The association between ambient air pollution and heart rate variability (HRV) has been well-documented. Little is known about the association of HRV at night with indoor air pollution and coffee consumption. The aim of this study was to investigate the association of HRV indices with…
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The -607C/A Polymorphisms in Interleukin-18 Gene Promoter Contributes to Cancer Risk: Evidence from A Meta-Analysis of 22 Case-Control Studies
Background: Several observational studies have investigated the association between -607 C/A polymorphism of IL-18 gene and cancer risk; however, the results were inconsistent. Therefore, we performed a meta-analysis to derive a more precise estimation of the association to help us better…
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Adiponectin receptor 1 resists the decline of serum osteocalcin and GPRC6A expression in ovariectomized mice
Hormonal changes that cause metabolic complications are a common problem in postmenopausal women. Adiponectin and osteocalcin are cytokines associated with glucose regulatory and insulin sensitized function in postmenopausal stages. The current study investigated the role of adiponectin signaling…
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NMD Classifier: A reliable and systematic classification tool for nonsense-mediated decay events
Nonsense-mediated decay (NMD) degrades mRNAs that include premature termination codons to avoid the translation and accumulation of truncated proteins. This mechanism has been found to participate in gene regulation and a wide spectrum of biological processes. However, the evolutionary and…
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Stathmin Mediates Hepatocyte Resistance to Death from Oxidative Stress by down Regulating JNK
Stathmin 1 performs a critical function in cell proliferation by regulating microtubule polymerization. This proliferative function is thought to explain the frequent overexpression of stathmin in human cancer and its correlation with a bad prognosis. Whether stathmin also functions in cell death…