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3 hasil untuk "Zhu, Li-Da"

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  1. Artikel Jurnal Teks lengkap

    A Machine Learning Method for Drug Combination Prediction

    Li, Jiang; Tong, Xin-Yu; Zhu, Li-Da dkk.

    Front Genet · 2020 · Inggris · PubMed Central

    Drug combination is now a hot research topic in the pharmaceutical industry, but experiment-based methodologies are extremely costly in time and money. Many computational methods have been proposed to address these problems by starting from existing drug combinations. However, in most cases, only…

  2. Artikel Jurnal Teks lengkap

    Facilitating Anti-Cancer Combinatorial Drug Discovery by Targeting Epistatic Disease Genes

    Quan, Yuan; Liu, Meng-Yuan; Liu, Ye-Mao dkk.

    Molecules · 2018 · Inggris · PubMed Central

    Due to synergistic effects, combinatorial drugs are widely used for treating complex diseases. However, combining drugs and making them synergetic remains a challenge. Genetic disease genes are considered a promising source of drug targets with important implications for navigating the drug space…

  3. Artikel Jurnal Teks lengkap

    Systems Chemical Genetics-Based Drug Discovery: Prioritizing Agents Targeting Multiple/Reliable Disease-Associated Genes as Drug Candidates

    Quan, Yuan; Luo, Zhi-Hui; Yang, Qing-Yong dkk.

    Front Genet · 2019 · Inggris · PubMed Central

    Genetic disease genes are considered a promising source of drug targets. Most diseases are caused by more than one pathogenic factor; thus, it is reasonable to consider that chemical agents targeting multiple disease genes are more likely to have desired activities. This is supported by a…