88 hasil untuk "Li-Yu Lin"
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Saliva-driven surface-engineered Bacteroides thetaiotaomicron alleviates hypertension
Oral environment is closely linked to blood pressure regulation. However, the underlying mechanisms remain poorly understood, and strategies for harnessing this relationship to modulate blood pressure are still scarce. Saliva, abundant in the oral cavity, was demonstrated to play a critical role in…
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O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis
High-risk human papillomaviruses (HPVs) are causative agents of anogenital cancers and a fraction of head and neck cancers. The mechanisms involved in the progression of HPV neoplasias to cancers remain largely unknown. Here, we report that O-linked GlcNAcylation (O-GlcNAc) and O-GlcNAc transferase…
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LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors
Liver kinase B1 (LKB1) functions as a tumor suppressor encoded by STK11, a gene that mutated in Peutz-Jeghers syndrome and in sporadic cancers. Previous studies showed that LKB1 participates in IR- and ROS-induced DNA damage response (DDR). However, the impact of LKB1 mutations on targeted cancer…
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Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension
The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and…
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Direct kinetic measurements and theoretical predictions of an isoprene-derived Criegee intermediate
Isoprene has the highest emission into Earth’s atmosphere of any nonmethane hydrocarbon. Atmospheric processing of alkenes, including isoprene, via ozonolysis leads to the formation of zwitterionic reactive intermediates, known as Criegee intermediates (CIs). Direct studies have revealed that…
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Nuclear receptor corepressor 1 represses cardiac hypertrophy
The function of nuclear receptor corepressor 1 (NCoR1) in cardiomyocytes is unclear, and its physiological and pathological implications are unknown. Here, we found that cardiomyocyte‐specific NCoR1 knockout (CMNKO) mice manifested cardiac hypertrophy at baseline and had more severe cardiac…
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Roles of oral microbiota and oral-gut microbial transmission in hypertension
INTRODUCTION: Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading to PD is known to aggravate different systematic diseases, but the alteration of oral microbiota in HTN and their impacts…
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Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells
BACKGROUND: Myocardial infarction (MI) is a high-prevalence disease that threatens human survival and quality of life worldwide. Considerable evidence has suggested that periodontitis (PD) is detrimental to MI. However, the direct impact of PD on MI is unclear; which oral pathobionts contribute to…