40,148 results
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Journal Article Full text
PROBAST+AI: an updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods
The Prediction model Risk Of Bias ASsessment Tool (PROBAST) is used to assess the quality, risk of bias, and applicability of prediction models or algorithms and of prediction model/algorithm studies. Since PROBAST’s introduction in 2019, much progress has been made in the methodology for…
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Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
BACKGROUND: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors. This paper presents GBD 2023 findings on disease and injury burden and…
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Minority Cultures and the Cosmopolitan Alternative
I have chosen not to talk in this Article about the warning that Rushdie is sounding in his essay In Good Faith, but to discuss more affirmatively the image of the modern self that he conveys. Still, I hope that we do not lose sight of the warning. The communitarianism that can sound cozy and…
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Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful risk factors, population growth, and…
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Free radicals and their impact on health and antioxidant defenses: a review
Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, as well as exogenous…
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edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets
edgeR is an R/Bioconductor software package for differential analyses of sequencing data in the form of read counts for genes or genomic features. Over the past 15 years, edgeR has been a popular choice for statistical analysis of data from sequencing technologies such as RNA-seq or ChIP-seq. edgeR…
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Application of Fourier Transform Infrared (FTIR) Spectroscopy in Characterization of Green Synthesized Nanoparticles
The fundamental principle of Fourier Transform Infrared (FTIR) spectroscopy is based on the vibration and rotation of atoms, and it has become a universal and widely used spectral methodology for the detection of internal molecular structures in a diverse range of fields. A considerable number of…
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Global Carbon Budget 2024
Accurate assessment of anthropogenic carbon dioxide (CO 2 ) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate is critical to better understand the global carbon cycle, support the development of climate policies, and project future…
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FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare
Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. This paper describes the FUTURE-AI framework, which provides guidance for the development and deployment of trustworthy AI tools in…
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2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias
1. Preamble 3 2. Introduction 5 3. Estimation of total cardiovascular risk and implications for dyslipidaemia management 5 4. New low-density lipoprotein cholesterol-lowering therapies 9 5. Combination of lipid-lowering therapies during index hospitalization for acute coronary syndromes 11 6…
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DESI DR2 results. II. Measurements of baryon acoustic oscillations and cosmological constraints
We present baryon acoustic oscillation (BAO) measurements from more than 14 million galaxies and quasars drawn from the Dark Energy Spectroscopic Instrument (DESI) Data Release 2 (DR2), based on three years of operation. For cosmology inference, these galaxy measurements are combined with DESI…
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Advancements and limitations in traditional anti-cancer therapies: a comprehensive review of surgery, chemotherapy, radiation therapy, and hormonal therapy
Cancer remains a major global health challenge, consistently ranking as the second leading cause of mortality worldwide. Despite significant advancements in research and technology, the need to deepen our understanding of tumor biology and improve therapeutic strategies persists. This review…
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The TRIPOD-LLM reporting guideline for studies using large language models
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Notes from Underground: Zines and the Politics of Alternative Culture
The third edition of Notes from Underground: Zines and the Politics of Alternative Culture by Stephen Duncombe was published in 2017. The author researches zines as an underground’s mouthpiece, as an opportunity for “losers” who do not fit in to speak up for themselves. According to Duncombe, zines…
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Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
BACKGROUND: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality…
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CoverM: read alignment statistics for metagenomics
SUMMARY: Genome-centric analysis of metagenomic samples is a powerful method for understanding the function of microbial communities. Calculating read coverage is a central part of analysis, enabling differential coverage binning for recovery of genomes and estimation of microbial community…
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Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021
OBJECTIVE: To predict the global, regional, and national prevalence of Parkinson's disease by age, sex, year, and Socio-demographic Index to 2050 and quantify the factors driving changes in Parkinson's disease cases. DESIGN: Modelling study. DATA SOURCE: Global Burden of Disease Study 2021. MAIN…
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Book Full text
Inequality: what can be done?
Economic inequality has become centre stage in the political debate, but what the political leaders have not said is what they would do about it. There are repeated calls for equitable growth but little clue as to how this is to be achieved. In this Working Paper, I seek to show what could be done…
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DESI 2024 IV: Baryon Acoustic Oscillations from the Lyman alpha forest
Abstract We present the measurement of Baryon Acoustic Oscillations (BAO) from the Lyman- α (Ly α ) forest of high-redshift quasars with the first-year dataset of the Dark Energy Spectroscopic Instrument (DESI). Our analysis uses over 420 000 Ly α forest spectra and their correlation with the…
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