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Spatiotemporal dynamics and forecasting of public attention to entrepreneurship education: An entropy-based modeling approach
Entrepreneurship education is increasingly important with the development of digital economy and post-pandemic. However, the distribution of public attention to entrepreneurship education (PAEE) remains unclear. Based on Baidu Index data from 2016 to 2024, this study first explores its…
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Structural transformation of a hydrogel-forming cell division protein ZapB of multidrug resistant Klebsiella pneumoniae with small molecules
Septal ring assembly protein ZapB (EMR18431.1) is involved in Z-ring formation, and nucleoid segregation during the bacterial cell division . It promotes cell division in the initial stages of the cell cycle through direct interaction with FtsZ, thus stimulating Z-ring assembly. The ZapB inhibition…
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Pain processing and pain assessment in Huntington’s disease: Study protocol of the Huntington’s disease - PAIN study
Background: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease that causes motor (e.g., chorea) and non-motor symptoms (e.g., neurocognitive, neuropsychiatric and autonomic disturbances). Pain is a frequently reported non-motor symptom in HD, with a prevalence of around…
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Digital referral experiences within Australian general practice: Insights from Chronic Obstructive Pulmonary Disease (COPD) care as an exemplar
Background: Digital referral platforms can strengthen communication between primary and specialist care and improve continuity for people with COPD. However, adoption in Australian primary care remains uneven across jurisdictions. Objective: To explore general practitioners’ (GPs) and practice…
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The impact of trade frictions on the financial vulnerability of Chinese households
In recent years, escalating trade frictions have exerted substantial shocks on the financial security of Chinese households. Drawing on data from the China Family Panel Studies (CFPS) for 2014–2022, this study constructs a standard difference-in-differences (DID) model, taking the 2018–2019 U.S…
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Large Scale Food Fortification (LSFF) in East, Central, and Southern Africa: Gaps, opportunities and the way forward
Background: Micronutrient deficiencies affect 2 billion people globally, especially in sub-Saharan Africa, where iron, vitamin A, iodine, zinc, calcium, selenium, folate, and vitamin B12 deficiencies are common. Large Scale Food Fortification (LSFF) – addition of micronutrients to commonly…
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Network pharmacology and integrative bioinformatics analyses identify PDE1A as a key target of pirfenidone in idiopathic pulmonary fibrosis
Pirfenidone, an antifibrotic agent, has been shown to be effective in the treatment of idiopathic pulmonary fibrosis (IPF). However, the exact mechanism of action and clinical efficacy require further investigation and validation. This study commenced by identifying pathogenic genes associated with…
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Effects of scapular-focused movement-based exercises on sports performance of athletes with scapular dyskinesis: A systematic review
Background: Scapular dyskinesis is a common dysfunction among athletes, particularly in overhead sports, leading to pain, reduced range of motion (ROM), and impaired performance. Movement-based exercises are increasingly used to address these issues, but their overall impact on sports performance…
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Effect of impregnation with polyethylene glycols (PEGs) of different end groups on gas separation performance of cross-linked polyethylene oxide (PEO) membranes
Polymer membranes offer an extremely attractive solution for achieving sustainable carbon dioxide capture and have the potential for large-scale application. The authors prepared almost amorphous polyethylene oxide separation membranes through cross-linking methods, with a CO2/H2 separation…
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The impact of imaginary future generations on the preference for carbon tax schemes
Carbon pricing instruments have been found to be an effective incentive to mitigate climate change, but that surely increases the burden on the current generation. Some previous experiments found that people will have fewer or delayed gains after imagining the future. This research employed an…
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Modeling insurance claims using Bayesian nonparametric regression
Predicting future insurance claims using observed covariates is essential for actuaries in setting appropriate insurance premiums. For this purpose, actuaries commonly employ parametric regression models, which assume the same functional form tying the response to the covariates across all data…
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Not just two languages: Using variation in language experience to understand how cognitive resources shape syntactic processing
Individuals who learn and use two languages come to that experience in many different ways. Recent studies have shown that to understand bilingualism, it is necessary to characterize the variation in experience that continually shapes the use of the two languages. The current investigation explored…
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The impact of water management and nitrification inhibitors on methane emissions from paddy soil
Methane (CH₄) is a potent greenhouse gas, and rice paddies are a major source of agricultural CH₄ emissions. Water management and nitrification inhibitors can significantly affect CH4 emissions, but their coupled effects on rhizospheric CH₄ emissions remain unclear. This study employed a rhizobox…
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Advanced machine learning-guided optimization platform for high-yield soluble expression of Pseudomonas aeruginosa exotoxin A in engineered Escherichia coli strains
Background: The recombinant production of Pseudomonas aeruginosa exotoxin A (ETA), a critical component for immunotoxin development, remains hindered by its complex disulfide bond architecture, cytotoxicity, and aggregation propensity. Despite recent advancements in strain engineering, a…
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Development and external validity of a nurse-led intervention program to improve palliative care and quality of dying and death in intensive care unit
Introduction: In Japan, end-of-life care in intensive care units (ICU) remains inconsistent and often suboptimal, contributing to variability in the quality of dying and death. This study aimed to develop a culturally appropriate nurse-led intervention program to improve the quality of dying and…
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Water-soluble gadolinium fullerenes Gd@C 82 -TEGs as a potential magnetic resonance imaging contrast agent
The water-soluble gadolinium fullerenes Gd@C82-TEGs nanoparticles as a novel magnetic resonance imaging (MRI) contrast agent were fabricated by the metal fullerenes Gd@C82 assembled with tetraethylene glycol (TEG). The loading Gd amount in Gd@C82-TEGs nanoparticles was 8.0 wt%. The average particle…
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WHO five moments for medication safety among diabetic patients in Saudi Arabia
Background: Diabetic patients are particularly vulnerable to medication errors. Assessing adherence to the WHO Five Moments for Medication Safety among diabetic patients is essential for identifying gaps in practice and improving patient safety in this high-risk group. This is the first study to…
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Risk factors for spontaneous abortion following hepatitis E vaccination during and shortly before pregnancy: Further analysis from a cluster-randomized trial
Background: A recent randomized trial of Hepatitis E Vaccine (HEV239) found an elevated risk of spontaneous abortion (SAB) in women given HEV239 during or within ninety days before pregnancy. Here we present additional analyses to better understand this risk. Methods: We investigated whether…
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Human resistin is critical to activation of the NLRP3 inflammasome in macrophages
Elevated levels of human resistin (hResistin) have been associated with diverse inflammatory diseases, but the precise mechanisms through which hResistin’s many inflammatory effects contribute to the progression of these diseases remain poorly understood. NLRP3 inflammasome activation is essential…
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Psychological help-seeking behaviours amongst those living with Inflammatory Bowel Disease; A cross-sectional, descriptive, correlational study
Aim: To explore the help-seeking preferences and behaviours of those living with Inflammatory Bowel Disease for negative emotions. Design: A cross-sectional, descriptive, correlational study. Methods: The sample consisted of 376 individuals living with Inflammatory Bowel Disease. Quantitative and…
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