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Sex- and nationality-based participation and performance trends in the Swissman Xtreme Triathlon (2019–2025)
Background: Participation and performance trends are well investigated for the IRONMAN® triathlon. For Xtreme Triathlons (XTri World Tour) races, only one study has examined participation and performance trends for the ‘Norseman Xtreme Triathlon’ in Norway, but not for other XTri World Tour events…
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Topology-aware design of spiking neural networks via modular graph architectures
Spiking Neural Networks (SNNs) offer a biologically plausible and energy-efficient alternative to traditional artificial neural networks (ANNs), yet their design remains constrained by limited architectural flexibility and slow training dynamics. In this work, we introduce a novel SNN framework…
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Association of visceral fat and plasmacytoid dendritic cell-derived interferon alpha with SARS-CoV-2 infection
Type I interferon (IFN-I: IFNα/β) production by plasmacytoid dendritic cells (pDCs) is critical for controlling viral infections. Visceral fat obesity is associated with severe outcomes in viral infections, but its effect on pDC-mediated IFN-I production in the context of SARS-CoV-2 infection…
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Endometriosis treatment pathways in the largest private health insurance in Brazil: A real-world data study
Introduction: Endometriosis is a prevalent chronic gynecological condition affecting women of reproductive age, characterized by ectopic endometrial-like tissue growth. Despite its significant impact on quality of life, fertility, and healthcare utilization, data on real-world treatment pathways in…
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Variation analysis of growth traits and medicinal components in different provenances of Polygonatum cyrtonema based on heterogeneous garden experiment
Polygonatum cyrtonema is a valuable medicinal and edible plant whose sustainable utilization is challenged by wild resource depletion and germplasm degradation. This study established a multi-site provenance trial across three heterogeneous garden environments in Zhejiang Province, China, to…
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Prevalence, associated factors, and association of intimate partner violence and suicidal behaviors among women of reproductive age in Asia: Protocol for a systematic review and meta-analysis of cross-sectional studies
Intimate partner violence (IPV) is strongly linked to suicidal behaviors (ideation, plans, attempts), affecting 1 in 3 women globally, with prevalence varying across regions. Sociocultural and economic factors shape IPV and SB risk differently. This review will estimate prevalence, risk factors…
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Inconsistent condom use and its associated factors among female sex workers in African countries: Systematic review and meta-analysis
Background: Inconsistent condom use represents the most proximal behavioral risk factor for acquisition and transmission of sexually transmitted infections, including human immunodeficiency virus. However, certain situations hinder female sex workers from practicing consistent condom use. This…
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Optimizing topical antibiotic delivery in dogs: Tear film pharmacokinetics of moxifloxacin following pre-treatment with hyaluronic acid
Purpose: To evaluate the impact of pre-treatment with mucoadhesive polymers on tear film concentrations of topically administered moxifloxacin in dogs. Methods: Eight healthy dogs were enrolled in a randomized paired-eye crossover study consisting of two sessions (7-day washout). Eyes received…
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The effectiveness of dry needling at myofascial trigger points for knee disorders: A quantitative synthesis of randomized controlled trials
Purpose: Dry needling (DN) targeting myofascial trigger points (MTrPs) has been proposed as a treatment for knee disorders, including knee osteoarthritis (KOA) and patellofemoral pain syndrome (PFPS). This meta-analysis evaluated the effectiveness of DN in improving pain and function in patients…
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Localized wastewater surveillance showed correlation but no early warning during Bengaluru’s Omicron wave
Wastewater surveillance is an effective tool for monitoring the spread of infectious diseases such as COVID-19. In August 2021, a citywide surveillance effort was initiated in Bengaluru to analyze viral loads from 28 sewage treatment plants (STPs). The study found a strong correlation between…
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DNA source and primer choice affect the reliability of metabarcoding for nematode community profiling in agricultural soils
The advent of metabarcoding has greatly advanced our understanding of nematode ecology by overcoming many limitations associated with traditional morphology-based methods. The NF1–18Sr2b (NF1) is the standard and widely used primer pair to assess nematode communities. However, this primer also…
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Sequencing complete plasmids on Oxford Nanopore Technologies sequencers using R2C2 and Chopper
Plasmids are ubiquitous tools in molecular biology which are used for a large variety of experiments within academic and commercial labs. Both new and old plasmids have to undergo sequencing-based analysis to determine whether or not they are functional, i.e., contain the correct insert in the…
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Genomic characterization of Comamonas kerstersii isolated from diarrheal patients in Bangladesh
This study marks the first identification and genomic characterization of Comamonas kerstersii isolates from diarrheal patients in Bangladesh. We carried out the whole genome sequencing of three C. kerstersii isolates to analyze genomic features using bioinformatics tools. We hypothesize that C…
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Can participative leadership and LMX congruence promote collective organizational engagement?
Employee engagement has been widely recognized as an important indicator of organizational functioning and performance. While prior research has primarily examined engagement at the individual level, emerging studies suggest that engagement may spread through social interactions, leading to a…
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Applying machine learning and natural language processing to patient safety event reports: Identifying patterns of cardiovascular diagnostic errors
Objective: To explore the utility of natural language processing (NLP) and machine learning (ML) techniques to identify unsafe conditions leading to cardiovascular diagnostic errors using patient safety event (PSE) reports data. Methods: PSE reports from January 2016 to August 2021 from a…
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Genomic dissection of methane emission traits in cattle: A meta-GWAS and heritability analysis across populations
Enteric methane emissions from ruminants represent a significant contributor to agricultural greenhouse gases, necessitating precise genetic tools to guide mitigation strategies. This study aimed to identify genomic regions and estimate heritability parameters associated with methane-related traits…
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Efficiency, accuracy and robustness of probability generating function based parameter inference method for stochastic biochemical reactions
Biochemical reactions are inherently stochastic, with their kinetics commonly described by chemical master equations (CMEs). However, the discrete nature of molecular states renders likelihood-based parameter inference from CMEs computationally intensive. Here, we introduce an inference method that…
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Spatial and temporal pattern evolution and driving characteristics of rural settlements in Xilingol League from 1915 to 1980
Population migration and agricultural expansion have profoundly reshaped the rural characteristics of Xilingol League, a typical pastoral region in northern China. From the perspective of historical geography, this study investigates the settlement evolution in Xilingol League during 1915–1980…
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Featuring the application of biochemistry in dental practice through a self-directed assignment: A descriptive study
Background: With advancements in the fields of treatment, diagnosis, and genomics, knowledge of cellular biochemistry is becoming increasingly crucial for oral health professionals. However, dental students often feel demotivated to study foundational-level biochemistry because they are overwhelmed…
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Assessing the influence of diverse skills on employability outcomes for IT undergraduates
Rapid technological advancements have reshaped the global job market, emphasizing the importance of specialized competencies such as user interface (UI) and user experience (UX) design, alongside technical and interpersonal skills.. This study examines how UI/UX skills (UIUX), soft skills (SS), and…
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