85 results
Showing 1–20 · 0.17 seconds · RSS
Journal of Infection
Scopus
ISSN 0163-4453 · Elsevier · 85 articles in the index
-
Journal Article
Target enriched metagenomics in cerebrospinal fluid in central nervous system infections
Summary: Objectives: Metagenomic next-generation sequencing (mNGS) is a promising tool for identifying pathogens. Targeted enrichment may improve detection in samples with low pathogen loads. We evaluated targeted mNGS for the diagnosis of central nervous system infections. Methods: We evaluated…
-
Journal Article
Clinical characteristics, outcomes and molecular epidemiology of group B streptococcal disease in young infants in the Netherlands
Summary: Objectives: Group B streptococcus (GBS) disease remains a major cause of morbidity and mortality in young infants. We conducted a prospective multi-centre cohort study to evaluate clinical outcomes, molecular epidemiology, and coverage of potential maternal vaccines candidates in the…
-
Journal Article
Potential Targets of Naturally Acquired
Summary: Background: Malaria transmission-blocking vaccines induce functional immunity, impeding Plasmodium parasite development in mosquitoes and thereby reducing malaria transmission. We aim to identify target antigens of naturally acquired transmission-blocking antibodies against Plasmodium…
-
Journal Article
Dose-dependent efficacy of intravenous brincidofovir across adenovirus species in immunocompromised patients
Summary: Objectives: Invasive infections caused by different human adenovirus (HAdV) species represent a life-threatening complication in immunocompromised patients, but no approved antiviral treatment is currently available. Methods: Using PCR-based screening and next-generation sequencing (NGS)…
-
Journal Article
Household transmission dynamics of human respiratory syncytial virus in China: A multicentre epidemiological and molecular study
Summary: Objectives: To estimate the secondary HRSV infection proportion, age-specific susceptibility, inferred spread, and HRSV-A/B transmission patterns in Chinese households. Methods: This prospective case-ascertained household cohort in Zhejiang, China (November 2024-December 2025) recruited…
-
Journal Article
Association of asymptomatic
Summary: Objectives: We examined how asymptomatic Plasmodium falciparum ( Pf ) infections and their treatment affect short-term cognitive trajectories among schoolchildren living in western Kenya and explored whether subclinical inflammation may contribute to this relationship. Methods: In this…
-
Journal Article
Microbe-induced migrasome-like structures and their role in microbial persistence, immune evasion and transmission
Summary: Microbial pathogens have evolved sophisticated strategies to disseminate within hosts, yet the full repertoire of intercellular transmission routes remains incompletely understood. Traditional models of microbial spread emphasize free-particle diffusion and direct cell-to-cell contact…
-
Journal Article
Genetic analysis of human adenovirus type 7 circulating in China during 2014-2025
Summary: Objectives: Human adenovirus type 7 (HAdV-7) has caused outbreaks of acute respiratory infections (ARIs) among children in multiple countries. This study aimed to investigate the clinical and genetic characteristics of HAdV-7 in hospitalized children with ARIs in China. Methods…
-
Journal Article
Oropharyngeal microbiome signatures associated with meningococcal carriage in healthy young adults
Summary: Background: Neisseria meningitidis (Nm) colonizes the oropharynx of healthy individuals, yet the relationship between the oropharyngeal microbiome and meningococcal carriage remains poorly characterized. We studied the oropharyngeal microbiome in relation to Nm carriage and capsular…
-
Journal Article
Core biomarkers and early detection criteria of cytokine storm triggered by infectious diseases: A systematic review and meta analysis
Summary: Objective: Cytokine storm (CS) is a critical immunopathological mechanism contributing to disease severity, organ failure, and mortality in infectious diseases. However, standardized clinical diagnostic criteria, particularly for early-stage CS, remain lacking. This systematic review and…
-
Journal Article
Cross-neutralizing antibody responses to diverse coronaviruses in the human population
The COVID-19 pandemic has substantially reshaped population humoral immunity. However, whether individuals in the post-pandemic era have developed broader cross-neutralizing antibody responses against diverse coronaviruses remains unclear. To address this question, we evaluated serum neutralizing…
-
Journal Article
Spatial patterns of rodent-borne pathogens and ecological suitability of rodent-borne diseases in China
Background: Rodent-borne pathogens pose important global health risks, yet national-scale assessments linking host-pathogen ecology with disease dynamics remain limited, particularly in China. Methods: We compiled global (>29,000 records) and China-specific (2235 records; 1950–2023) rodent-pathogen…
-
Journal Article
Effectiveness and waning of the fourth dose mRNA COVID-19 vaccines for the prevention of SARS-CoV2 infection related hospitalisations and deaths
Summary: Background: Real-world data studies suggest that the vaccine effectiveness (VE) of a fourth mRNA vaccine dose against SARS-CoV2 infection related hospitalisation wanes after a few months, potentially warranting consideration of additional booster doses. Methods: A multi-data source cohort…
-
Journal Article
Pre-existing and cross-reactive immunity to avian influenza H5N1 in humans: Implications for pandemic risk and vaccine strategies
Summary: Due to the continuous evolution of Influenza A viruses (IAVs), novel strains with efficient human-to-human transmission may emerge and cause future pandemics. Among these, highly pathogenic avian influenza (HPAI) H5N1 remains a major concern because of its impact on wildlife, livestock…
-
Journal Article
Impact of dosing interval on immunogenicity following a heterologous typhoid conjugate vaccine booster in Nepalese children: An observational study
Summary: Objectives: Typhoid conjugate vaccines (TCVs) are essential for controlling endemic typhoid fever in low- and middle-income countries. However, evidence suggests that TCV-induced protection wanes 3–5 years post-vaccination, particularly among children vaccinated before two years of age…
-
Journal Article
Cefiderocol in clinical practice: From randomised trials to real-world evidence in the management of multidrug-resistant Gram-negative bacterial infections
Objectives: Multidrug-resistant Gram-negative bacteria (MDR-GNB) represent a major global health threat, with limited therapeutic options and high morbidity and mortality. Cefiderocol, a novel siderophore cephalosporin, has emerged as a potential treatment for MDR-GNB infections. This narrative…
-
Journal Article
Neonatal sepsis and meningitis caused by Group B Streptococcus or
Summary: Objectives: Neonatal sepsis in one twin poses a dilemma in managing the healthy-appearing sibling. Shared exposures and genetic factors increase risk, and early signs of sepsis can be subtle with rapid deterioration. However, the magnitude of this risk for the healthy twin is unclear, and…
-
Journal Article
Serological outcomes of SARS-CoV-2 infection by vaccination status and variant in England
Summary: Background: Throughout the SARS-CoV-2 pandemic, several vaccines have been rolled out and distinct variants with different severity and immune profiles emerged in England. Using data from enhanced surveillance of COVID-19 in vaccine eligible individuals we investigated the antibody…
-
Journal Article
A prospective cohort study of the clinical profile of
Summary: Objectives: To define the clinical features of Acinetobacter spp. infection in Northern Thailand, including a comparison of hospital-acquired culture positives (HACP) and community-acquired infections (CAIs). Methods: A prospective clinical study of Acinetobacter spp. infections at two…
-
Journal Article
Genomic characterisation of ST11-KL19 carbapenem-resistant
Summary: Objectives: The global convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae poses a critical public health threat. While ST11-KL64 has historically dominated in China, the evolutionary dynamics driving the emergence of novel high-risk sublineages remain poorly…