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Biological Research
Scopus
ISSN 0716-9760 · BMC · 1,590 articles in the index
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Journal Article
Role and mechanisms of vascular smooth muscle cell phenotypic transition in diabetic macrovascular complications
Abstract Diabetic macrovascular complications, as one of the leading causes of mortality in diabetic patients, are characterized by insidious onset and high residual risk. Effective prevention and treatment of diabetic macrovascular injury remain critical clinical challenges, necessitating the…
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Journal Article
Rewiring brain structural and functional disconnection with acupuncture in rat model of vascular cognitive impairment and dementia
Abstract Background Connectional “diaschisis” theory indicates that the remote functional network disconnection resulting from focal white matter damage contributes to the cognitive dysfunction in vascular cognitive impairment and dementia (VCID). Acupuncture has been reported to attenuate white…
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Journal Article
Ameliorative effect of pomegranate peel extract nanoparticles and ovarian stem cells-derived exosomes on cyclophosphamide-induced premature ovarian insufficiency
Abstract Background Premature ovarian insufficiency (POI) is a fertility disorder impacting women under 40, characterized by an early deterioration of ovarian function, and is one of the major side effects caused by chemotherapy. Cyclophosphamide is a powerful chemotherapeutic agent used in various…
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Journal Article
Effects of sheep follicular fluid-derived exosomes and miR-148a on theca cell function in vitro
Abstract Background Exosomes facilitate intercellular communication by transporting proteins, nucleic acids, and other biomolecules, impacting recipient cell functions. In follicular development, exosomes from follicular fluid, secreted by granulosa cells, oocytes, and theca cells (TCs), are…
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Journal Article
Targeting endoplasmic reticulum stress in diabetic retinopathy: mechanistic insights and emerging therapies
Abstract Purpose To summarize the role of endoplasmic reticulum stress (ERS) in the pathogenesis of diabetic retinopathy (DR) and evaluate potential ERS-targeted interventions. Methods This review analyzes recent preclinical and clinical studies focusing on the molecular mechanisms of ERS and its…
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Journal Article
Lifelong cGAS deficiency leads to altered lipid storage and cholesterol homeostasis
Abstract Background The complex interaction between the immune system and metabolic homeostasis is becoming recognized, as immune sensors affect key metabolic tissues, including the liver and adipose tissue. The cGAS–cGAMP–STING pathway, previously recognized as a cytosolic DNA-sensing pathway, is…
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Journal Article
Vascular smooth muscle cell RNA-binding protein U2AF2 induces copper death by regulating C1qbp expression, delaying development of atherosclerosise
Abstract Background Atherosclerosis (AS) is the main pathological basis of atherosclerosis-related cardiovascular and cerebrovascular diseases. The phenotypic conversion and death mechanisms of vascular smooth muscle cells (VSMCs) are crucial during its development. This study reveals the molecular…
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Journal Article
Tissue-specific reference gene stability for qPCR in thermally conditioned quail embryos
Abstract The reliability and accuracy of relative quantification of transcripts through quantitative real-time PCR (qPCR) is dependent on the use of stable reference genes for normalization. However, the expression stability of various reference genes may differ across the tissues and…
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Journal Article
Telomerase as a therapeutic Bullseye: advances in cancer treatment and clinical trials
Abstract Telomeres play a crucial role in maintaining genomic stability in healthy cells. However, they gradually shorten during the cell cycle, leading to chromosomal instability. Telomere length and telomerase activity are vital factors that counteract cellular degradation in cancer development…
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Journal Article
Phenotyping of post-fertilization sperm mitophagy determinants discovered in a mammalian gamete-based cell-free system
Abstract The targeted, substrate-specific degradation of paternal mitochondria inside the zygote, known as post-fertilization sperm mitophagy, is a crucial and evolutionarily conserved early embryonic event. It ensures the exclusive maternal inheritance of the mitochondrial genome…
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Journal Article
A successful stacking of multiple biotic stress resistance in rice facilitated by genes and precision breeding tools
Abstract Background Genetic improvement of rice for biotic stress is a major and continuous breeding objective owing to changing pest and disease scenarios. In response to climate change, an outbreak of new pathotypes and biotypes results in huge yield loss which directly impacts the economic…
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Journal Article
Generation of a stable mouse endometrial tumor-derived cell line using conditional reprogramming
Abstract Background Endometrial cancer (EC) is a common malignancy of the female reproductive tract worldwide. While comprehensive genomic analyses have identified multiple genetic alterations in EC, disease models remain relatively rare, limiting the ability to conduct disease studies…
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Journal Article
Integrated morphological, pomological, biochemical, and ISSR-based assessment of genetic diversity in wild sour orange (Citrus aurantium L.) genotypes from the Hassa district of Hatay, Türkiye
Abstract Sour orange (Citrus aurantium L.) is a hybrid species of considerable agronomic, medicinal, and industrial importance; however, its wild genetic resources remain largely underexplored. This study evaluated 24 naturally occurring wild sour orange genotypes collected from the Hassa district…
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Journal Article
Regulation of trophoblast fusion dysfunction in preeclampsia by the NCK1/EIF3D/PPARG axis
Abstract Background Abnormal syncytialization of cytotrophoblast (CTB) cells is known to be associated with preeclampsia (PE), however, the underlying molecular mechanisms remain elusive. Results In this study, proteomic analysis of placental tissues was performed to identify proteins involved in…
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Journal Article
Effects of MICT and HIIT on mitochondrial dynamics-related proteins in visceral adipose tissue of type 2 diabetic rats
Abstract Background Adipose tissue, as an endocrine gland, significantly influences the pathophysiology of type 2 diabetes (T2DM) through mitochondrial dysfunction. This study examined the effects of two exercise training types on mitochondrial dynamic protein content in visceral adipose tissue…
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Journal Article
Impact of Salvadora persica aqueous extract on follicular development in female rats
Abstract Salvadora persica (miswak) has many useful biological activities. Some studies have reported that miswak can be used as a contraceptive agent. However, no available investigations explain the histomorphological structure of ovarian follicles after miswak aqueous extract (MAE)…
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Journal Article
Characterization of GH18 chitinase in Leishmania braziliensis: expression, structural insights, and implications for vaccine and therapeutic development
Abstract Chitinases, a group of glycosyl hydrolases (GHs), catalyze the degradation of chitin by releasing N-acetylglucosamine subunits. GHs can be found in all three domains of life. Among the three GH families (GH18, GH19, and GH20), GH18 chitinases are the most conserved and extensively studied…
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Journal Article
OGDH mediates α-ketoglutarate-induced follicular development and antioxidative response by interacting with CAT/SOD2
Abstract Background Follicular disorders, often driven by ROS-induced granulosa cell apoptosis, are a major cause of female infertility. While α-ketoglutarate (AKG), also known as 2-oxoglutarate, can improve follicular development, the underlying mechanisms remain unclear. Given that AKG is the…
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Journal Article
INO80 regulates promoter-associated R-loops to coordinate transcription and maintain genome stability in embryonic stem cells
Abstract Background Embryonic stem cells (ESCs) possess a distinctive cell cycle structure and chromatin landscape that necessitate precise coordination between transcription and DNA replication. The chromatin remodeler INO80 regulates both transcription and genome stability; however, its role in…
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Journal Article
IL-21 silencing inhibits the proliferation, growth, and migration of colorectal cancer cells via suppressing phosphorylation of ERK1/2 and STAT3
Abstract Background This study aimed to elucidate the proliferative and migratory roles of interleukin-21 (IL-21) in HCT-116 and HT-29 colorectal cancer cells using a loss-of-function gene approach. Methods The short hairpin ribonucleic acid (shRNA)- and short interfering ribonucleic acid…
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