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Platelets
Scopus
ISSN 0953-7104 · Taylor & Francis Group · 1.086 artikel di indeks
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Artikel Jurnal
The use of light transmission aggregometry for monitoring platelet transfusion response in a small case cohort of Glanzmann thrombasthenia patients: a hypothesis-generating study
Light transmission aggregometry (LTA) is commonly used to diagnose platelet disorders and has a specific pattern in Glanzmann thrombasthenia (GT). As there is currently no adequate test to assess the efficacy of platelet transfusion, we explored whether LTA can be used to monitor the platelet…
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Artikel Jurnal
Immature platelet fraction as a prognostic marker in patients with pulmonary embolism
Introduction Immature platelet fraction (IPF), a population of young platelets with distinct histological and functional characteristics, is associated with adverse outcomes in several cardiovascular diseases. However, data on the role of IPF in acute pulmonary embolism (PE) is limited. The…
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Artikel Jurnal
Prediction of bleeding and thromboembolic complications in patients on chronic hemodialysis with the total thrombus-formation analysis system
Patients receiving hemodialysis (HD) are susceptible to bleeding and thrombosis. We assessed whether the T-TAS assay – which measures platelet thrombus formation (PL-AUC) and fibrin-rich thrombus formation (AR-OT) in whole blood under flow - could predict these complications in 176 chronic HD…
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Artikel Jurnal
Adaptive immune and platelet activation during the maintenance phase of therapy in adults with B cell acute lymphoblastic leukemia
Background Maintenance therapy is an integral component of treatment for B cell acute lymphoblastic leukemia (B-ALL) and has demonstrated clinical efficacy. However, features of immune activation and an increased thrombotic risk may persist beyond the induction phase of treatment. The mechanisms…
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Artikel Jurnal
Autosomal dominant thrombocytopenia associated with the CYCS p.Arg92Gly variant: clinical characterization of an additional family and observation of antiplatelet tolerance
Thrombocytopenia 4 (THC4) is a rare autosomal dominant inherited thrombocytopenia caused by pathogenic variants in CYCS, the gene encoding cytochrome c. Although CYCS-related thrombocytopenia is well characterized as a mild, non-syndromic quantitative platelet disorder, few families have been…
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Artikel Jurnal
Developmental differences in platelet P-selectin expression modulate neonatal monocyte inflammatory responses
Neonatal and adult platelets are functionally different, with neonatal platelets being comparatively hypo-reactive to multiple platelet agonists. When transfused, neonates receive platelets from adult donors, resulting in a cellular developmental mismatch. Platelets are key regulators of the…
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Artikel Jurnal
The mitochondrial deacetylase SIRT3 is nonessential for cyclophilin D-dependent procoagulant platelet formation in mice
Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD)-dependent mitochondrial deacetylase that regulates protein acetylation and maintains mitochondrial homeostasis in nucleated cells. By deacetylating cyclophilin D (CypD), SIRT3 limits mitochondrial permeability transition pore (mPTP)…
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Artikel Jurnal
Hexokinase controls platelet activation and hemostasis
Platelet activation is energy-dependent and associated with a hyperglycolytic phenotype, yet the role of key glycolytic enzymes remains unclear. We investigated the role of platelet hexokinases (HK1 and HK2) in regulating thrombin- and convulxin-stimulated bioenergetics, functions, and hemostasis…
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Artikel Jurnal
Durable platelet response and immature platelet indices following sequential efgartigimod and eltrombopag therapy in a patient with refractory ITP
Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, represents a novel therapeutic approach for refractory immune thrombocytopenia (ITP). However, its clinical positioning and durability of response in real-world settings remain unclear. We describe a case of refractory ITP in which…
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Artikel Jurnal
Sex differences in fecal microbiota transplantation for mitigating radiation-induced thrombocytopenia in mice: efficacy amplified by inulin
Background Fecal microbiota transplantation (FMT) shows potential in promoting hematopoiesis, with efficacy influenced by donor sex. However, its role in radiation-induced thrombocytopenia (RIT) and its sex-specific effects remain unclear. While inulin may enhance FMT efficacy, this has not been…
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Artikel Jurnal
Effects of serum vitamin D on platelet function and bleeding in primary immune thrombocytopenia
Primary immune thrombocytopenia (ITP) is an autoimmune mediated thrombocytopenia with destruction and impaired production of platelets. Though life-threatening bleeding can occur in ITP, bleeding symptoms are often mild relative to platelet count. ITP is also associated with an increased…
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Artikel Jurnal
Assessing mitochondrial function and protein composition in platelet-derived extracellular vesicles
Platelets, traditionally known for their role in hemostasis, also contribute to inflammation, cancer, and intercellular communication through the release of platelet-derived extracellular vesicles (or platelet-derived microparticles; PMPs). Among these vesicles, a subpopulation containing…
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Artikel Jurnal
Endogenous spermidine biosynthesis contributes to fetal liver megakaryopoiesis and platelet production in mice
Metabolic regulation is increasingly recognized as an important determinant of megakaryocyte development and platelet production, yet the metabolite-level characteristics of primary megakaryocytes from distinct developmental stages and tissue origins remain incompletely defined. Here, using…
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Artikel Jurnal
Platelet-erythrocyte complex production is exacerbated by histones and protected by small polyanion histone neutralizing compounds
Platelet-erythrocyte (PE) complexes, composed of single erythrocytes bound to platelets, are a physiological component of the bloodstream and contribute to erythrocyte turnover. Conditions in which PE complex production is increased or their clearance from the circulation is impeded are associated…
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Artikel Jurnal
Abnormal expansion of peripheral helper T cells in primary immune thrombocytopenia
Peripheral helper T (Tph) cells, a distinct T-cell subset defined as CD4+PD-1hiCXCR5− phenotypically, are increasingly recognized as key drivers of antibody-mediated autoimmunity; however, their role in primary immune thrombocytopenia (ITP) remains poorly defined. In this study, we evaluated…
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Artikel Jurnal
Single-cell transcriptome deciphers key targets of thrombopoietin receptor agonists and immune microenvironment characteristics of immune thrombocytopenia
Thrombopoietin receptor agonists (TPO-RAs) represent a cornerstone in immune thrombocytopenia (ITP) management, yet their molecular mechanisms remain incompletely elucidated. This study systematically deciphered the key targets and signaling networks of four TPO-RAs (romiplostim, eltrombopag…
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Artikel Jurnal
Platelets induce VISTA expression and modulate the ovarian tumor microenvironment
Immune checkpoint regulators, such as the V-domain Ig suppressor of T cell activation (VISTA), play a critical role in shaping the tumor microenvironment (TME) and facilitating immune evasion. In ovarian cancer, VISTA exhibits more abundant and consistent expression than other immune checkpoints…
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Artikel Jurnal
Neural network reveals platelet age from fluorescence microscopy images
Platelets are small, anucleate cells with a primary physiological role in vascular damage repair (hemostasis) and initiation of thrombus formation in response to vascular injury. Platelets circulate approximately 7–10 days, slowly undergoing age-related changes in molecular composition, morphology…
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Artikel Jurnal
Pilot study on cannabis-induced alterations in platelet function: implications for transfusion medicine
Platelet transfusions are essential in the management of thrombocytopenia, bleeding disorders, and hematologic malignancies. With cannabis use rising worldwide, its impact on donor platelet quality and transfusion efficacy remains poorly understood. This study investigated the effects of cannabis…
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