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Cell Transplantation
Scopus
ISSN 0963-6897 · SAGE Publishing · 4,238 articles in the index
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Journal Article
A pilot phase IIa randomized, placebo-controlled, double-blind trial of intravenous human pluripotent adipose-derived stem cells (PASCs) in Parkinson’s disease: The REPOSE study
Pluripotent adipose-derived stem cells (PASCs) are a non-tumorigenic, stress-enduring SSEA-3 + cell population sharing key biological markers with Muse cells while representing a phenotypically distinct population. This Phase IIa randomized, double-blind, placebo-controlled pilot trial evaluated…
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Journal Article
Machine learning models using longitudinal laboratory data predict survival in allogeneic stem cell recipients
Allogeneic hematopoietic stem cell transplantation (HSCT) remains a potentially curative therapy for hematologic malignancies and bone marrow failure syndromes, yet outcomes remain highly heterogeneous and existing prognostic tools rely predominantly on pre-transplant clinical characteristics. We…
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Journal Article
Potential therapeutics ingredients for dental pulp regeneration focusing on DPSCs and DPSC secretome with market projection
Regeneration of dental pulp has surfaced as an exciting area of exploration in regenerative endodontics, as a result of progress in stem cell biology and their applications, along with biomaterials. Of the different cell populations studied, dental pulp stem cells (DPSCs) are recognized as…
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Journal Article
Safety and preliminary efficacy of allogeneic umbilical cord–derived mesenchymal stem cells administered via the hepatic artery in patients with liver cirrhosis: A phase I open-label trial
Liver cirrhosis causes substantial morbidity, and options beyond transplantation are limited. Umbilical cord–derived mesenchymal stem cells (UC-MSCs) may support liver repair, but their delivery via the hepatic artery has not been evaluated. This study assessed the safety and exploratory efficacy…
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Journal Article
Pre-transplant infection predicts subsequent gastrointestinal GVHD and non-relapse mortality after allogeneic hematopoietic stem cell transplantation
This study aimed to define the incidence of Clostridioides difficile infection (CDI), identify its risk factors, and evaluate its association with early post-transplant complications and overall clinical outcomes. To characterize CDI in the allogeneic hematopoietic stem cell transplantation…
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Journal Article
Isolation of functional human islets from pancreatectomy remnants: Determinants of yield and functionality
Human pancreatic islets are essential for studies in β-cell biology, cell transplantation, and tissue engineering, yet access to viable human islets remains limited because conventional isolation protocols primarily rely on whole pancreases from deceased donors. Surgical pancreatectomy specimens…
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Journal Article
Autologous chemically induced liver progenitor cell transplantation ameliorates steatosis and fibrosis in a preclinical miniature pig model of metabolic dysfunction–associated fatty liver disease: A pilot study
Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder and can progress to steatohepatitis and fibrosis; although approved pharmacotherapies for metabolic dysfunction–associated steatohepatitis (MASH) with fibrosis remain limited. Autologous…
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Journal Article
Mitochondrial transplantation as an immunomodulatory strategy: Modulating polymorphonuclear leukocytes for functional tissue regeneration
Following biomaterial implantation, modulation of the acute immune response is essential for tissue regeneration. Polymorphonuclear leukocytes (PMNs) are critical effector cells in wound healing, and PMN dysfunction is mediated by mitochondrial dysfunction and can lead to prolonged inflammation and…
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Journal Article
Comparison of the efficacy of pre-transplant and post-transplant antithymocyte globulin combined with post-transplant cyclophosphamide for graft--host disease prophylaxis in myeloablative haploidentical peripheral blood stem cell transplantation
Although post-transplant cyclophosphamide (PTCy) is widely used to prevent graft-versus-host disease (GVHD), its protective effect remains inadequate in patients undergoing myeloablative haploidentical peripheral blood stem cell transplantation (haplo-PBSCT). We retrospectively evaluated the…
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Journal Article
Amniotic epithelial cells enhance islet engraftment by suppressing early inflammation in intraportal transplantation
Amniotic epithelial cells (AECs) have immunomodulatory and anti-inflammatory properties that may improve outcomes in cell transplantation. However, their effect on islet engraftment after intraportal co-transplantation remains unclear. We evaluated the impact of co-transplanting syngeneic 600 islet…
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Journal Article
Hotspots and trends in stem cell therapy for ligament injuries: A bibliometric analysis (2001–2025)
Ligament injuries can lead to lasting instability and early joint degeneration despite rehabilitation or surgery. Stem cell therapies may aid regeneration, but studies are highly variable. Bibliometric analysis can summarize trends, hotspots, and research gaps. We searched the Web of Science Core…
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Journal Article
Three-dimensionally printed mesoporous bioactive glass for craniomaxillofacial bone regeneration: Material evolution, functional mechanisms, and clinical translation
Craniomaxillofacial (CMF) bone defects pose significant regenerative challenges due to complex anatomy and physiological demands. While autologous bone grafting remains the gold standard, it is limited by donor-site morbidity and supply constraints. Mesoporous bioactive glass (MBG), characterized…
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Journal Article
Cdc42-Modified BMSC-Derived exosomes promote acellular nerve allografts to bridge sciatic nerve defects
Peripheral nerve injury (PNI) often results in persistent functional deficits, and current treatments remain suboptimal. This study developed a tissue-engineered graft by integrating Cdc42-modified bone marrow-derived mesenchymal stem cell (BMSC)-derived exosomes (Exos-Cdc42) with an acellular…
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Journal Article
Organ-on-a-chip as a next-generation tool in drug development: A bibliometric and patent analysis
Organ-on-a-chip (OoC) platforms are microengineered systems that combine microfluidic control with living cells to emulate the physiological functions of human tissues and organs in vitro. OoC has become a transformative tool in pharmaceutical research, offering unprecedented capabilities for…
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Journal Article
Optimizing dose and delivery route in mesenchymal stromal cells (MSCs)-based therapy: A systematic review of their implications for clinical efficacy
Mesenchymal stromal cell (MSC)–based therapies have demonstrated broad therapeutic potential across inflammatory, degenerative, and neurological disorders; however, clinical outcomes remain highly variable, largely due to heterogeneity in cell source, dosing strategies, routes of administration…
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Journal Article
Role of tumor microenvironment composition and metabolism in lymphoid malignancies and therapeutic strategies
The tumor microenvironment (TME) plays a significant role in the occurrence, development, and prognosis of lymphomas. The mechanisms of each TME component in lymphoma and related therapeutic strategies are reviewed in this article. In the immune-related TME, regulatory T-cells (Tregs)…
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Journal Article
Research advances in bioactive bone graft materials and bone marrow enrichment techniques for bone defect treatment
Bone defects arise from trauma, infection, tumor resection, or congenital deformities, with large defects often progressing to nonunion. Autologous bone grafting is considered the gold standard therapy due to its osteoconductive, osteoinductive, and osteogenic properties, but it is limited by…
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Journal Article
Analysis of the efficacy and survival of allogeneic hematopoietic stem cell transplantation and nontransplantation treatment in chronic active Epstein–Barr virus infection
This retrospective study evaluated 75 patients with chronic active Epstein–Barr virus infection (CAEBV) to compare the efficacy and survival outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) and programmed death-1 (PD-1) blockade therapy. Patients were classified into HSCT and…
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Journal Article
Comparative analysis of the bio-safety of HuMSCs and HuMenSCs in the nude mice and their impacts on reproductive organs’ histological morphology
The tumorigenesis and long-term bio-function of the implanted mesenchymal stromal cells (MSCs) were needed before clinical applications. We herein observed 7 months and investigated the viable tumors formation, the survival rate, the distribution of the injected cells in different reproductive…
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Journal Article
Long-term complete remission and minimal side effects after CD19/CD22 CAR-T cell cocktail therapy in a living donor with DLBCL: A rare case report
Chimeric antigen receptor T-cell (CAR-T) therapy is a breakthrough in cancer treatment that can induce durable remission in patients with hematological malignancies who have failed prior therapies. As the use of CAR-T cell therapy increases, treatment-related renal complications deserves careful…
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