94 results

Quantitative Imaging of the Mandibular Condyle: Radiomics and Microarchitectural Biomarkers

Daniel Negrete; Ana Cristina Borges-Oliveira; Marcos Murilo Alves Santos et al.

Medical Principles and Practice, Pp 1-22 (2026) · 2026 · English · DOAJ Scopus

Radiomics makes it possible to extract quantitative data from medical images, revealing details about tissue heterogeneity that are not apparent from visual evaluation alone. Conventional evaluation of temporomandibular joint (TMJ) imaging still primarily relies on qualitative morphological…

Proactive Prevention of Postpartum Hypothyroidism: The Critical Role of Community-Based Diet and Micronutrient Supervision

Yiyun Xu; Qingzhao Xie

Medical Principles and Practice, Pp 1-29 (2026) · 2026 · English · DOAJ Scopus

Postpartum thyroiditis (PPT) is a common autoimmune sequela of pregnancy, affecting 5-10% of women, a considerable percentage of whom ultimately develop lifelong hypothyroidism. The disorder's characteristic symptoms, such as debilitating tiredness and cognitive impairment, are frequently…

Cytokine Profiles in Peripheral Blood Mononuclear Cells and Neutrophils following SARS-CoV-2 Vaccination: A Study from Kuwait.

Sahar Essa; Mais A. Abdulwahab; Raj Raghupathy

Medical Principles and Practice, Pp 1-22 (2026) · 2026 · English · DOAJ Scopus

COVID-19 continues to be associated with substantial morbidity and mortality, and understanding vaccine-induced immune regulation beyond antibody responses remains important. This study characterized cytokine profiles in peripheral blood mononuclear cells (PBMC) and neutrophils following SARS-CoV-2…

The Efficacy of Integrating Problem-Based Learning with the BOPPPS Six-Step Methodology in Endocrinology Clinical Instruction

Ting Liu; Wanwei Guo; Bo Chen et al.

Medical Principles and Practice, Pp 1-20 (2026) · 2026 · English · DOAJ Scopus

Objectives: The objectives of the study were to evaluate the efficacy of the Problem-Based Learning (PBL) with the Bridge-in, Objective, Pre-assessment, Participatory learning, Post-assessment, and Summary (BOPPPS) PBL-BOPPPS model compared to conventional instruction in endocrinology clinical…

Longitudinal Psychosocial and Sleep Assessments for Long-Term Cardiovascular Risk Stratification After First Myocardial Infarction in Rural India

Bhargava Sai Mukkirla; Bebeto Rai; Debarshi Dey et al.

Medical Principles and Practice, Pp 1-19 (2026) · 2026 · English · DOAJ Scopus

Objectives: The risk of myocardial infarction (MI) evolves beyond the acute phase, and in-hospital tools, such as the Global Registry of Acute Coronary Events (GRACE) score, may not fully capture long-term vulnerability. We evaluated whether simple longitudinal clinical and patient-reported…

The Effect on Vitamin D Levels and VDR Gene Polymorphism on Clinical Outcomes in Asthma

Gülden Deniz Aksu; Nurhan Sarıoğlu; Mustafa Çolak et al.

Medical Principles and Practice, Pp 1-17 (2026) · 2026 · English · DOAJ Scopus

Objective: This study aimed to investigate the relationship between vitamin D receptor gene polymorphism and vitamin D levels with asthma severity, control level and exacerbation status in asthmatic patients. Subjects and Methods: Over a six-month period, 162 patients diagnosed with asthma and 85…

Efficacy and Safety of Glibenclamide on Functional Outcomes and Cerebral Edema following Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Amir Hegazi; Rashad G. Mohamed; Muataz Kashbour et al.

Medical Principles and Practice, Vol. 35 No. 1 · 2026 · English · DOAJ Scopus

Objective: This systematic review and meta-analysis aimed to evaluate the clinical and radiological outcomes of glibenclamide versus control in acute stroke. Methods: In accordance with PRISMA guidelines, a comprehensive literature search was conducted to identify relevant studies up to January 15…

Role of Specific miRNA Expression and Nuclear Kappa B Gene Polymorphism as Potential Diagnostic Markers for Chronic Myeloid Leukemia

Jehad F. Alhmoud; Moath Alqaraleh; Sarah N. Dala-Ali et al.

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Objective: This study assesses microRNA-21 (miR-21) and microRNA-302 (miR-302) levels and examines their association with a nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) gene single nucleotide polymorphism (SNP) in chronic myeloid leukemia (CML) patients, aiming to identify…

Evaluating the Predictive Value of the Endothelial Activation and Stress Index in Determining the Severity and Prognosis of Acute Pulmonary Embolism

Orhan Karayiğit; Muhammet Cihat Çelik; Murat Gök et al.

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Objectives: The endothelial activation and stress index (EASIX) has gained growing recognition as a potential marker for evaluating endothelial dysfunction and survival outcomes across diverse clinical conditions. This research aimed to assess the utility of the EASIX score in predicting disease…

Comparative Effectiveness of Mycophenolate Mofetil and Tacrolimus as a Second-Line Therapy for Autoimmune Hepatitis: A Systematic Review and Meta-Analysis

Fahd Almalki; Sarah T. Alarmati; Razan N. Shata et al.

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Objective: Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disease that usually responds to corticosteroids ± azathioprine (AZA). However, some patients are intolerant or refractory to first-line therapy and require second-line immunosuppression. Mycophenolate mofetil (MMF) and…

Reply to: “Recurrent Takotsubo: Interpreting the 5.9-Fold 30-Day Cardiovascular Mortality Signal”

Moritz Mirna; Albert Topf

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Oral Manifestations in Children with Celiac Disease: Part I – Prevalence of Dental Enamel Defects and Recurrent Aphthous Stomatitis and Their Association with Disease-Related Factors

Sibel Acar; Ertugrul Sabah; Maşallah Baran et al.

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Objectives: Celiac disease (CD) is an immune-mediated disorder triggered by gluten, often presenting with oral manifestations: dental enamel defects (DEDs) and recurrent aphthous stomatitis (RAS). This study aimed to determine the prevalence of DEDs and RAS in children with CD and to identify the…

The Effectiveness of a Hospital-Based Antimicrobial Stewardship Program: A Three-Year Observational Study

Partha Guchhait; Tamanna Saha; Bhaskar Narayan Chaudhuri et al.

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Objective: The aim of the study was to evaluate the impact of a policy-driven Antimicrobial Stewardship Program (AMSP) on antibiotic consumption, prescribing compliance, infection control, resistance trends, and clinical outcomes in a tertiary care hospital in India over a 3-year period. Subject…

National Institutes of Health Stroke Scale Scoring Tool Utilizing Medical Records: A Single-Center Validation Study

Aser F. Alamri; Faisal F. Alamri; Ahmed Alkhiri et al.

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Objective: The prospective National Institutes of Health Stroke Scale (NIHSS) assessment is the standard for evaluating stroke severity. This study aimed to develop and validate an enhanced retrospective NIHSS (r-NIHSS) scoring method that integrates structured keyword mapping and established…

Inhaled Aviptadil for Post-COVID Lung Injury: Early Promise, Future Directions

Eric J. Charles; Faisal A. Shaikh; Zoltan H. Nemeth

Medical Principles and Practice, Vol. 35 No. 1 · 2026 · English · DOAJ Scopus

Investigation of <italic>CLDN5</italic> Gene 3′ Untranslated Region rs10314 Polymorphism and Protein Levels in Children and Adolescents with Attention-Deficit Hyperactivity Disorder: A Molecular and Clinical Correlation Study

Emine Göktaş; Necati Uzun; Tuğba Deniz Kurnaz Demir et al.

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Introduction: This study aimed to examine the association between the rs10314 polymorphism in the 3′ untranslated region (3′UTR) of the CLDN5 gene and attention-deficit hyperactivity disorder (ADHD) and to evaluate the serum claudin-5 levels in relation to genotype and clinical severity. Methods: A…

An Overview of Beriberi

Amanda Gomes Pereira; Letycia Netto de Paula Cunha; Sergio Alberto Rupp Paiva et al.

Medical Principles and Practice, Vol. 35 No. 1 · 2026 · English · DOAJ Scopus

Beriberi is a nutritional disorder caused by thiamine deficiency. Classically, Beriberi presents in two primary clinical forms: “wet” Beriberi, which features heart and circulatory system impairment, and “dry” Beriberi, which causes polyneuropathy. Although it is an easily treatable condition, it…

Prevalence and Impact of Lower Urinary Tract Symptoms among Women with Rheumatoid Arthritis: A Multicenter Cross-Sectional Study

Ghadeer Alshaikh; Baydaa Alsannan; Dana Aldabeeb et al.

Medical Principles and Practice, Vol. 35 No. 3 · 2026 · English · DOAJ Scopus

Objectives: This study aimed to determine the prevalence of voiding dysfunction and its impact on quality of life among women diagnosed with rheumatoid arthritis, a chronic autoimmune condition known for joint inflammation and systemic manifestations. Methods: A cross-sectional observational design…

Immunological Profile of Patients with Rheumatoid Arthritis and Asthma

Sana S. Almutairi; Fawaz Y. Azizieh; Adeeba A. Al-Herz et al.

Medical Principles and Practice, Vol. 35 No. 1 · 2026 · English · DOAJ Scopus

Introduction: The aim of this study was to investigate cytokine profiles in patients with both rheumatoid arthritis (RA) and bronchial asthma (BA). Methods: We studied 25 patients with RA, 25 with BA, and 25 with both RA and BA (BARA). A respiratory questionnaire was completed by all the patients…

Response to Letter on “Inhaled Aviptadil for Post-COVID Lung Injury: Early Promise, Future Directions”

Dorina Esendagli

Medical Principles and Practice, Vol. 35 No. 1 · 2026 · English · DOAJ Scopus