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Clinical and Experimental Hypertension
Scopus
ISSN 1064-1963 · Taylor & Francis Group · 844 artikel di indeks
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Artikel Jurnal
Association of blood pressure dipping status with Naples Prognostic Score and arterial stiffness in newly diagnosed hypertensive patients
Background Abnormal circadian blood pressure variation, particularly a non-dipper pattern, is associated with increased cardiovascular risk. Naples Prognostic Score (NPS) is a laboratory-based score that reflects the immune-inflammatory and nutritional status. Nevertheless, data regarding the…
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Artikel Jurnal
Presenting non-insulin-based indices of insulin resistance relevant to pre-hypertension: A systematic review and meta-analysis
Background Using reliable, simple, and cost-effective tools to identify pre-hypertension (pre-HTN) early is crucial for reducing the risk of cardiovascular disease (CVD). This systematic review and meta-analysis aimed to assess the association between the risk of pre-HTN and non-insulin-based…
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Artikel Jurnal
Association of carotid body size with left atrial strain and peripheral hemodynamics in patients with hypertension: An exploratory study
Background The carotid body (CB) is a key regulator of sympathetic tone, and its overactivity is implicated in the pathogenesis of neurogenic hypertension. While structural enlargement of the CB may reflect chronic autonomic dysregulation, its association with early markers of hypertension-mediated…
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Artikel Jurnal
Assessment of the safety and effectiveness of catheter-based renal denervation with the symplicity spyral system in patients with resistant hypertension: A single-center experience
Background Renal denervation (RDN) has emerged as a potential therapeutic option for resistant hypertension (HT), which remains a major clinical challenge due to poor blood pressure (BP) control despite optimized pharmacotherapy. This study aimed to assess the safety and effectiveness of…
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Artikel Jurnal
Relationship between kidney length and renal risk in malignant hypertension patients with renal thrombotic microangiopathy
Background Malignant hypertension (mHTN) is a severe hypertensive emergency, often associated with renal deterioration. Kidney length may be of useful to identify patients with renal dysfunction. Whether kidney length in mHTN patients is associated with renal prognosis is unclear.Methods The study…
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Artikel Jurnal
Hypertensive disorders of pregnancy: A comprehensive review of pathophysiology, diagnosis, treatment, and long-term cardiovascular implications
Hypertensive disorders of pregnancy (HDP) are common and clinically consequential, affecting ~5%–10% of pregnancies and contributing substantially to maternal and perinatal morbidity and mortality. This review summarizes key concepts that inform bedside decision-making, including contemporary…
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Artikel Jurnal
Genetic determinants of hypertension: A meta-analysis of AGTR1 and CYP11B2 gene polymorphisms
Background Hypertension, or high blood pressure, is a long-lasting condition caused by sustained high blood pressure in the arteries. The increase and decrease of blood pressure is greatly affected by both dietary and physiological factors. Hence, hypertension may pose serious risks of developing…
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Artikel Jurnal
ANXA2, DBN1, ZNF385D, and IL6ST: Endothelial cell biomarkers linking atherosclerosis progression to immune microenvironment dysregulation
Background Atherosclerosis (AS) is a complex cardiovascular disorder driven by endothelial cell dysfunction and immune microenvironment dysregulation. We identified novel endothelial-related diagnostic biomarkers through multi-omics integration and machine learning approaches.Methods Single‑cell…
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Artikel Jurnal
Bulk and single-cell transcriptomics for identification of potential diagnostic biomarkers associated with pulmonary arterial hypertension and integrated stress response and experimental validation
Background Pulmonary arterial hypertension (PAH) is a lethal vascular disorder characterized by irreversible remodeling of the pulmonary arteries, but the systematic role of the integrated stress response (ISR)-related genes (ISR-RGs) in its pathogenesis remains unexplored.Objective This study…
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Artikel Jurnal
Dissecting burden of alcoholic cardiomyopathy: age-period-cohort analysis from the global burden of disease study 2019
Background Alcoholic cardiomyopathy (ACM) is a major cause of cardiovascular morbidity and mortality, characterized by ventricular dilation and impaired contractility resulting from chronic heavy alcohol use. Understanding its temporal and demographic trends is vital for guiding targeted public…
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Artikel Jurnal
Effects of time-restricted eating on blood pressure in children: A cluster randomized controlled trial
Background This study aimed to evaluate the safety and efficacy of a time-restricted eating (TRE) intervention to reduce blood pressure (BP) in children and adolescents.Methods We conducted a 12-month, three-arm cluster-randomized controlled trial in two schools, with classes as the unit of…
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Artikel Jurnal
Serum endothelin-1 and endothelin-2 levels in healthy controls and circadian hypertension phenotypes: A comparison of dipper and non-dipper patients
Objective The aim of this study was to evaluate serum endothelin-1 (ET-1) and endothelin-2 (ET-2) levels in patients with dipper and non-dipper hypertension compared to normotensive controls and to investigate the potential diagnostic value of these biomarkers in distinguishing circadian blood…
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Artikel Jurnal
AMPK-dependent maturation of hiPSC-derived cardiomyocytes induced by human cardiac fibroblast exosomes
Background Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a promising therapy for ischemic cardiomyopathy, which is often secondary to hypertension but remain functionally immature. We investigated whether exosomes from human cardiac fibroblasts (hc-FB-EXOs) promote…
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Artikel Jurnal
Mechanisms linking hypertension to cardiovascular and cerebrovascular diseases and their clinical implications: A comprehensive review
Hypertension, one of the most prevalent chronic conditions worldwide, stands as a principal risk factor for cardiovascular and cerebrovascular diseases, including coronary heart disease and stroke. Recent advances have clarified a graded, dose–response relationship in which higher blood pressure is…
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Artikel Jurnal
Preliminary study of individualized therapy for ventricular septal defect with severe pulmonary arterial hypertension
Background Pulmonary arterial hypertension (PAH) is a serious complication of congenital heart disease (CHD) with a left-to-right shunt, particularly ventricular septal defect (VSD). In patients presenting with severe PAH, therapeutic decision-making remains challenging because precise and…
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Artikel Jurnal
Chemerin - CMKLR1 signaling contributes to immune metabolic dysfunction in salt-sensitive hypertension
Salt-sensitivity of blood pressure (SSBP) is a significant cardiovascular risk factor, but its underlying immunometabolic mechanisms remain unclear. Chemerin, an adipose-derived inflammatory mediator linked to vascular dysfunction, was studied in 30 hypertensive adults (mean age 53.1 years; 53%…
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Artikel Jurnal
Adiponectin improves the aortic dissection by inhibiting inflammatory cell infiltration and macrophage pyroptosis
Objective Aortic dissection (AD) is a fatal cardiovascular emergency that is predominantly induced by long-term uncontrolled hypertension.Materials and methods The mouse AD model was established by combining β-aminopropionitrile with angiotensin II. The incidence rate, rupture rate, and survival…
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Artikel Jurnal
Electroacupuncture for essential hypertension: Mechanistic insights, current clinical evidence, and translational challenges
Background Essential hypertension (EH) remains a leading modifiable risk factor for cardiovascular morbidity and mortality worldwide. Electroacupuncture (EA), combining traditional acupuncture with pulsed electrical stimulation at specific acupoints, has attracted growing attention as a potential…
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Artikel Jurnal
Association of intracranial atherosclerotic stenosis with 1-year cognitive impairment after acute ischemic stroke or transient ischemic attack: a nationwide prospective cohort study
Background and purpose Intracranial atherosclerotic stenosis (ICAS) is common in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA), but its relationship with long-term cognitive impairment remains unclear. This study examined whether ICAS was associated with 1-year…