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Experimental and Molecular Medicine
Scopus
ISSN 1226-3613 · Nature Publishing Group · 1.399 artikel di indeks
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Artikel Jurnal
Colorectal microenvironment determines the prognosis of colorectal cancer
Abstract Here we aimed to evaluate the feasibility of distinguishing colorectal microenvironments that support cancer cell growth from those that do not. We hypothesized that patients whose non-tumor-bearing tissue (NBT) obtained from the furthest margins of resected cancer specimens resembled the…
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Artikel Jurnal
Mcu regulates bone formation via mitochondrial calcium uptake and lineage allocation
Abstract The mitochondrial calcium uniporter (Mcu) mediates calcium influx into the mitochondrial matrix, playing an essential role in cellular energy metabolism and survival. Although Mcu has been studied in various physiological contexts, its role in skeletal homeostasis remains poorly…
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Artikel Jurnal
Isoform-specific roles of QKI-6 and QKI-7 direct Schwann cell lineage progression and enhance peripheral nerve regeneration
Abstract Peripheral nerve injury presents a major therapeutic challenge owing to limited endogenous repair and incomplete functional recovery. Schwann cells (SCs), the principal glia of the peripheral nervous system, support axonal integrity and regeneration, but the post-transcriptional mechanisms…
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Artikel Jurnal
De novo and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics
Abstract Growth differentiation factor-15 (GDF15), a stress-responsive cytokine of the transforming growth factor-β superfamily, is elevated in cancer cachexia, chemotherapy-induced nausea, and hyperemesis gravidarum, making it both a biomarker and a therapeutic target. Here, we developed…
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Artikel Jurnal
Machine learning-based integration of transcriptome and digital pathology for predicting chemoresistance in muscle-invasive bladder cancer
Abstract Muscle-invasive bladder cancer (MIBC) presents with variable clinical and pathological features, leading to inconsistent responses to standard treatments such as neoadjuvant chemotherapy (NAC). Although transcriptome profiling has shown differences in NAC response, reliable predictors of…
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Artikel Jurnal
TopBP1 orchestrates PU.1–IRF8 transcriptional programming of dendritic cell differentiation and Flt3L-driven tumor immunity
Abstract DNA topoisomerase II-binding protein 1 (TopBP1) plays a critical role in V(D)J recombination and DNA damage repair during B and T cell development. However, its role in the development of conventional dendritic cells (cDCs) remains unexplored. Mice with DC-specific depletion of TopBP1…
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Artikel Jurnal
From inflammation to fibrosis and cancer: the emerging role of AIEC-derived metabolites in intestinal disease progression
Abstract The intestinal microbiota maintains mucosal homeostasis through dynamic host–microbe interactions. When this balance is disrupted, gut dysbiosis drives inappropriate immune activation, leading to dysregulated inflammation that contributes to the pathogenesis of chronic inflammatory…
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Artikel Jurnal
Iron overload reprogramming lipid metabolism through the IRP1–SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis
Abstract Rheumatoid arthritis (RA) is a leading cause of disability globally. Although iron accumulation in arthritic lesions has been observed in patients with RA, its specific contribution to disability outcomes remains unclear. Here we demonstrate a comprehensive multiomics approach to elucidate…
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Artikel Jurnal
Zinc as a master regulator of intracellular organelle homeostasis
Abstract Zinc (Zn²⁺) is an essential trace element that supports a vast array of cellular processes, including enzymatic catalysis, gene expression, immune regulation and signaling. Its unique redox-inert properties and ability to bind diverse proteins make it indispensable for cellular…
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Artikel Jurnal
MeCP2 regulates cell-type-specific functions of depressive-like symptoms in the nucleus accumbens
Abstract Methyl-CpG binding protein 2 (MeCP2) is a chromatin-associated transcriptional regulator that modulates neuronal gene programs in response to environmental stimuli. Although MeCP2 has been implicated in stress responses and depression, its cell-type-specific functions within defined limbic…
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Artikel Jurnal
Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation
Abstract How intestinal stem cells (ISCs) are regulated during inflammation remains largely unexplored, leading to a lack of effective treatments for inflammatory bowel diseases (IBD). ISC-mediated intestinal epithelial regenerative repair can be regulated by intra-epithelial T lymphocytes, whose…
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Artikel Jurnal
Spatiotemporal precision interventions for cardiac repair and regenerative therapy
Abstract Restoring cardiac function after myocardial infarction remains a major challenge, as current pharmacological and interventional therapies primarily mitigate symptoms and slow disease progression without addressing the irreversible loss of functional myocardium. Although a diverse range of…
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Artikel Jurnal
Decoding spontaneous intracerebral hemorrhage: mechanistic breakthroughs and disruptive revolution in pharmacological treatment
Abstract Spontaneous intracerebral hemorrhage (ICH), especially hypertensive basal ganglia hemorrhage, is a severe, often fatal stroke subtype with high morbidity and mortality. This historical review traces therapeutic progress from the 1960s to the present, emphasizing rehabilitation…
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Artikel Jurnal
Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation
Abstract The development of compounds triggering intestinal stem cells (ISCs) proliferation represents a promising strategy to alleviate irradiation (IR)-induced gastrointestinal syndrome. Here, cannabidiol (CBD)-a nonpsychotomimetic phytocannabinoid derived from the Cannabis sativa plant-was found…
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Artikel Jurnal
Hepatocyte estrogen-related receptor α modulates a gluconeogenic–epigenetic crosstalk counteracting MASLD/MASH progression
Abstract Lactate has been recognized as a major fuel substrate and also a lactyl-group donor for histone lysine lactylation. Hepatocytes act as lactate-consuming cells owing the high oxidative capability especially during exercise, a primary nonpharmacological intervention for alleviating metabolic…
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Artikel Jurnal
SLC38A4 promotes Kupffer cell phagocytosis and suppresses tumor liver metastasis
Abstract Metastasis is the main cause of cancer-related death. The liver is an organ with high metastatic tropism for various malignancies. Hepatic-resident macrophage Kupffer cells are the major non-parenchymal cells in the liver that phagocytize disseminated tumor cells to restrict liver…
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Artikel Jurnal
N-terminal formylmethionine as a degron and a specific signal in proteostasis and stress adaptation
Abstract N-terminal (Nt) methionine formylation, once thought restricted to bacteria and organelles, is now recognized as a stress-inducible initiator modification in the eukaryotic cytosol. Under metabolic or environmental stress, mitochondrial methionyl-transfer RNA (tRNA) formyltransferase…
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Artikel Jurnal
Metabolic adaptations of immunosuppressive cells in cancer: mechanisms and therapeutic targets
Abstract The tumor microenvironment harbors diverse immunosuppressive cell populations—including regulatory T cells, myeloid-derived suppressor cells, tumor-associated macrophages and other tolerogenic subsets—that drive immune evasion and therapeutic resistance. These cells are metabolically…
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Artikel Jurnal
EHMT2 aggravates vascular remodeling via epigenetic inhibition of GADD45G
Abstract Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) has been implicated in cardiovascular diseases, yet its role in vascular remodeling remains incompletely understood. Here we investigated the contribution of EHMT2 to vascular smooth muscle cell (VSMC) proliferation, migration and…
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